The crotonase superfamily: Divergently related enzymes that catalyze different reactions involving acyl coenzyme a thioesters

Accounts of Chemical Research

Volumn 34, Issue 2, 2001, Pages 145-157

  Holden, H M ^b   Benning, M M ^b   Haller, T ^a   Gerlt, J A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; ENOYL COENZYME A HYDRATASE; ESTER;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CATALYSIS; CHEMICAL BINDING; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; GEOMETRY; HYDROLYSIS; LIVER MITOCHONDRION; MOLECULAR GENETICS; PROTEIN CONFORMATION; PSEUDOMONAS; RAT; SEQUENCE HOMOLOGY;

ACYL COENZYME A; AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; ENOYL-COA HYDRATASE; ESCHERICHIA COLI; ESTERS; MITOCHONDRIA, LIVER; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PSEUDOMONAS; RATS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035113799     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar000053l     Document Type: Article

References (36)

1. Understanding enzyme superfamilies: Chemistry as the fundamental determinant in the evolution of new catalytic activities
2. Mechanistically diverse enzyme superfamilies: The importance of chemistry in the evolution of catalysis
3. The enolase superfamily: A general strategy for enzyme-catalyzed abstraction of the α-protons of carboxylic acids
4. Structure of 4-chlorobenzoyl coenzyme a dehalogenase determined to 1.8 Å resolution: An enzyme catalyst generated via adaptive mutation
5. Crystal structure of enoyl-coenzyme a (CoA) hydratase at 2.5 Å resolution: A spiral fold defines the CoA-binding pocket
6. The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule
7. The crystal structure of dienoyl-CoA isomerase at 1.5 Å resolution reveals the importance of aspartate and glutamate side chains for catalysis
8. New reactions in the crotonase superfamily: Structure of methylmalonyl CoA decarboxylase from Escherichia coli
9. Microbial degradation of biphenyl and its derivatives
10. 18O]-water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from Pseudomonas spec. CBS 3
11. Novel enzymic hydrolytic dehalogenation of a chlorinated aromatic
12. Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3
13. Specificity of 4-chlorobenzoyl coenzyme a dehalogenase catalyzed dehalogenation of halogenated aromatics
14. Evidence for nucleophilic catalysis in the aromatic substitution reaction catalyzed by 4-chlorobenzoyl coenzyme a dehalogenase
15. 13C-NMR spectral studies of dehalogenase complexes of benzoyl-CoA adducts
16. Identification of active site residues essential to 4-chlorobenzoyl-coenzyme a dehalogenase catalysis by chemical modification and site directed mutagenesis
17. Investigation of substrate activation by 4-chlorobenzoyl-coenzyme a dehalogenase
18. Raman study of the polarizing forces promoting catalysis in 4-chlorobenzoate-CoA dehalogenase
19. Modulating electron density in the bound product, 4-hydroxybenzoyl-CoA, by mutations in 4-chlorobenzoyl-CoA dehalogenase near the 4-hydroxy group
20. Interchange of catalytic activity within the 2-enoyl-coenzyme a hydratase/isomerase superfamily based on a common active site template
21. The interpretation of protein structures: Estimation of static accessibility
22. Enoyl coenzyme a hydratase (Crotonase). Catalytic properties of crotonase and its possible regulatory role in fatty acid oxidation
23. Substrate stereochemistry of the enoyl-CoA hydratase reaction
24. Molecular cloning and sequence analysis of the cDNA for rat mitochondrial enoyl-CoA hydratase. Structural and evolutionary relationships linked to the bifunctional enzyme of the peroxisomal β-oxidation system
25. 2,4-dienoyl-CoA isomerase
26. Discovering new enzymes and metabolic pathways: Conversion of succinate to propionate by Escherichia coli
27. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold
28. Bacterial carnitine metabolism
29. 2-Ketocyclohexanecarboxyl coenzyme a hydrolase, the ring cleavage enzyme required for anaerobic benzoate degradation by Rhodopseudomonas palustris
30. Menaquinone (Vitamin K2) biosynthesis: Nucleotide sequence and expression of the menB gene from Escherichia coli
31. Sequence of proton abstraction and stereochemistry of the reaction catalyzed by naphthoate synthase, an enzyme involved in menaquinone (Vitamin K2) biosynthesis
32. Purification and partial characterization of 3-hydroxyisobutyryl-coenzyme a hydrolase of rat liver
33. Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme a hydrolase
34. Enoyl-CoA hydratase and isomerase form a superfamily with a common active-site glutamate residue
35. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures