Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity

Journal of Biological Chemistry

Volumn 279, Issue 25, 2004, Pages 26066-26073

  Freiberg, Christoph ^a   Brunner, Nina A ^a   Schiffer, Guido ^a   Lampe, Thomas ^a   Pohlmann, Jens ^a   Brands, Michael ^a   Raabe, Martin ^a   Häbich, Dieter ^a   Ziegelbauer, Karl ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOSYNTHESIS; CATALYST SELECTIVITY; CHARACTERIZATION; ENZYMES; FATTY ACIDS;

ANTIBACTERIAL ACTIVITY; MUTATION;

BIOCHEMISTRY;

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE INHIBITOR; ANDRIMID; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; CIPROFLOXACIN; ENZYME INHIBITOR; LIVER ENZYME; MALONYL COENZYME A; MOIRAMIDE B; NATURAL PRODUCT; POLYPEPTIDE ANTIBIOTIC AGENT; PSEUDOPEPTIDE; PSEUDOPEPTIDE PYRROLIDINEDIONE ANTIBIOTIC AGENT; RECOMBINANT ENZYME; SYNTHETIC PEPTIDE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; COMPETITIVE INHIBITION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME SPECIFICITY; ENZYME SUBUNIT; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; GENE MUTATION; GENETIC CONSERVATION; IC 50; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RAT; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ACETYL-COA CARBOXYLASE; AMIDES; AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; BACILLUS SUBTILIS; BACTERIA; BINDING, COMPETITIVE; CARBON-NITROGEN LIGASES; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESCHERICHIA COLI; INHIBITORY CONCENTRATION 50; KINETICS; LIVER; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS; SUCCINIMIDES; TIME FACTORS;

ANIMALIA; BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

EID: 2942718769     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402989200     Document Type: Article

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