Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics

European Journal of Medicinal Chemistry

Volumn 40, Issue 8, 2005, Pages 782-791

  Kranjc, Andreja ^a   Mašič, Lucija Peterlin ^a   Reven, Sebastjan ^a   Mikic, Klemen ^a   Preželj, Andrej ^b   Stegnar, Mojca ^c   Kikelj, Danijel ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b Lek Pharmaceuticals   (Slovenia)

^c UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

Arginine side chain mimetics; Enantiomers; Stereoselective action; Thrombin inhibitors

Indexed keywords

2 [6 CHLORO 2 OXO 3 [[2 (2 PYRIDINYL)ETHYL]AMINO] 1(2H) PYRAZINYL] N (4,5,6,7 TETRAHYDRO 2H INDAZOL 5 YLMETHYL)ACETAMIDE; ARGININE; BLOOD CLOTTING FACTOR 10A; FUSED HETEROCYCLIC RINGS; PYRAZINONE; PYRIDONE DERIVATIVE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; STEREOCHEMISTRY; SUBSTITUTION REACTION; THROMBOCYTE AGGREGATION INHIBITION;

ANTITHROMBINS; ARGININE; BIOMIMETIC MATERIALS; HYDROGEN-ION CONCENTRATION; PYRAZINES; PYRIDONES; STEREOISOMERISM;

EID: 23944464008     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.03.007     Document Type: Article

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