Novel non-covalent thrombin inhibitors incorporating P1 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics

European Journal of Medicinal Chemistry

Volumn 39, Issue 3, 2004, Pages 257-265

  Marinko, Petra ^a   Krbavčič, Aleš ^a   Mlinšek, Gregor ^b   Šolmajer, Tomaž ^b,c   Bakija, Alenka Trampuš ^d   Stegnar, Mojca ^d   Stojan, Jure ^a   Kikelj, Danijel ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^c Lek Pharmaceuticals   (Slovenia)

^d UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

cyclohexylalanine; 4,5,6,7 tetrahydrobenzothiazole; 4,5,6,7 Tetrahydrobenzothiazole; Arginine side chain mimetic; BTZ; Chx; Peptidomimetics; Thrombin inhibitors

Indexed keywords

1 (2 AMINO 3,3 DIPHENYLPROPANOYL) N (2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL) 2 PYRROLIDINECARBOXAMIDE; 1 [2 [[(2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL)AMINO]CARBONYL]PYRROLIDINYL] 3 (3,4 DICHLOROPHENYL) 1 OXO 2 PROPANAMINE; 2 [[2 [2 [[(2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL)AMINO]CARBONYL]PYRROLIDINYL] 1 (CYCLOHEXYLMETHYL) 2 OXOETHYL]AMINO]ACETIC ACID; 2 AMINO N (2 AMINO 1,3 BENZOTHIAZOL 6 YL)ACETAMIDE; BENZOTHIAZOLE DERIVATIVE; N (2 AMINO 1,3 BENZOTHIAZOL 6 YL) 1 [2 [(BENZYLSULFONYL)AMINO] 3 PHENYLPROPANOYL] 2 PYRROLIDINECARBOXAMIDE; N (2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL) 1 [2 [(BENZYLSULFONYL)AMINO] 3 (3,4 DICHLOROPHENYL)PROPANOYL] 2 PYRROLIDINECARBOXAMIDE; N (2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL) 1 [2 [(BENZYLSULFONYL)AMINO] 3 CYCLOHEXYLPROPANOYL] 2 PYRROLIDINECARBOXAMIDE; N (2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL) 1 [2 [(BENZYLSULFONYL)AMINO] 3 PHENYLPROPANOYL] 2 PYRROLIDINECARBOXAMIDE; N [(2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL)METHYL] 1 [2 [(BENZYLSULFONYL)AMINO] 3 CYCLOHEXYLPROPANOYL] 2 PYRROLIDINECARBOXAMIDE; N [2 [(2 AMINO 1,3 BENZOTHIAZOL 6 YL)AMINO] 2 OXOETHYL] 2 [(BENZYLSULFONYL)AMINO] 3 PHENYLPROPANAMIDE; N [2 [(2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL)AMINO] 1 METHYL 2 OXOETHYL] 2 [(BENZYLSULFONYL)AMINO] 3 PHENYLPROPANAMIDE; N [2 [(2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL)AMINO] 2 OXOETHYL] 2 [(BENZYLSULFONYL)AMINO] 3 PHENYLPROPANAMIDE; TERT BUTYL 2 [2 [[(2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL)AMINO]CARBONYL]PYRROLIDINYL] 1 BENZHYDRYL 2 OXOETHYLCARBAMATE; TERT BUTYL 2 [[2 [2 [[(2 AMINO 4,5,6,7 TETRAHYDRO 1,3 BENZOTHIAZOL 6 YL)AMINO]CARBONYL]PYRROLIDINYL] 1 (CYCLOHEXYLMETHYL) 2 OXOETHYL](TERT BUTOXYCARBONYL)AMINO]ACETATE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; X RAY CRYSTALLOGRAPHY;

ARGININE; BINDING SITES; BIOMIMETIC MATERIALS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIAZOLES; THROMBIN; TRYPSIN;

EID: 1642317384     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2003.12.006     Document Type: Article

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