A general synthesis of novel conformationally restricted arginine side- chain mimetics

Tetrahedron Letters

Volumn 41, Issue 29, 2000, Pages 5589-5592

  Mašič, Lucija P ^a   Kikelj, Danijel ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Arginine side chain mimetics; Serine proteases

Indexed keywords

ARGININE; SERINE PROTEINASE INHIBITOR;

ACETYLATION; ANALYTIC METHOD; ARTICLE; CONFORMATIONAL TRANSITION; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; REACTION ANALYSIS;

EID: 0343962161     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00869-8     Document Type: Article

References (20)

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8. The results will be published elsewhere.
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15. The application of other protecting groups is currently under study.
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17. 2: C, 64.26; H, 8.99; N, 12.49. Found: C, 63.95; H, 8.89; N, 12.39.
18. 4O: C, 59.98; H, 7.32; N, 25.44. Found: C, 59.76; H, 7.06; N, 25.21.
19. 3O: C, 62.15; H, 7.82; N, 21.74. Found: C, 61.88; H, 7.85; N, 21.44.
20. Compounds 3, 4, 10, 11 and 12 were obtained as racemates; experiments directed towards the preparation of pure enantiomers of arginine side-chain mimetics 2 are in progress.