Novel thrombin inhibitors incorporating weakly basic heterobicyclic P 1-arginine mimetics: Optimization via modification of P1 and P3 moieties

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3251-3256

  Kranjc, Andreja ^a   Peterlin Mašič, Lucija ^a   Ilaš, Janez ^a   Preželj, Andrej ^b   Stegnar, Mojca ^c   Kikelj, Danijel ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b Lek dd   (Slovenia)

^c UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

Arginine mimetics; Thrombin; Thrombin inhibitors

Indexed keywords

PYRIDONE DERIVATIVE; THROMBIN INHIBITOR;

ACIDITY; ANTICOAGULATION; ARTICLE; DRUG DESIGN; DRUG HYDROLYSIS; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; ROOM TEMPERATURE;

ARGININE; FIBRINOLYTIC AGENTS; HUMANS; SERINE PROTEINASE INHIBITORS; THROMBIN;

EID: 2442528331     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.085     Document Type: Article

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