Structure identification and prophylactic antimalarial efficacy of 2-guanidinoimidazolidinedione derivatives

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 3, 2005, Pages 699-704

  Guan, Jian ^a   Zhang, Quan ^a   Montip, Gettayacamin ^b   Karle, Jean M ^a   Ditusa, Charles A ^a   Milhous, Wilbur K ^a   Skillman, Donald R ^a   Lin, Ai J ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

Author keywords

Antimalarial; Carbamates; Guanidinoimidazolidinediones; WR182398

Indexed keywords

ANTIMALARIAL AGENT; CARBAMIC ACID DERIVATIVE; IMIDAZOLIDINE DERIVATIVE; N (3,4 DICHLOROPHENYL) N' ETHYLCARBONYL N'' (1 ISOPROPYL 4,5 DIOXOIMIDAZOLIDIN 2 YLIDENE)GUANIDINE; N [1 (3,4 DICHLOROPHENYL) 4,5 DIOXOIMIDAZOLIDIN 2 YLIDENE] N' ISOPROPYL N'' (ETHYLCARBONYL)GUANIDINE; ORGANIC SOLVENT; UNCLASSIFIED DRUG; WATER; WR 182393;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG PURIFICATION; DRUG SOLUBILITY; NONHUMAN; PLASMODIUM CYNOMOLGI; PROTON NUCLEAR MAGNETIC RESONANCE; RHESUS MONKEY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; GUANIDINES; IMIDAZOLES; MACACA MULATTA; MAGNETIC RESONANCE SPECTROSCOPY; MALARIA, FALCIPARUM; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

MACACA MULATTA; PLASMODIUM CYNOMOLGI; STAPHYLOCOCCUS PHAGE 3A;

EID: 11844267168     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.052     Document Type: Article

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