Synthesis and anti-Pneumocystis carinii pneumonia activity of novel dicationic dibenzothiophenes and orally active prodrugs

European Journal of Medicinal Chemistry

Volumn 34, Issue 7-8, 1999, Pages 575-583

  Patrick, Donald A ^a   Hall, James Edwin ^a,c   Bender, Brendan C ^a   McCurdy, Donald R ^a   Wilson, W David ^b   Tanious, Farial A ^b   Saha, Shankar ^a   Tidwell, Richard R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c IL   (United States)

Author keywords

Amidines; Dibenzothiophenes; Dications; DNA; Pneumocystis carinii pneumonia

Indexed keywords

DIBENZOTHIOPHENE DERIVATIVE; PENTAMIDINE; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DERIVATIZATION; DNA BINDING; DRUG EFFECT; DRUG SYNTHESIS; LIVER HOMOGENATE; METABOLIC REGULATION; NONHUMAN; OPPORTUNISTIC INFECTION; ORAL DRUG ADMINISTRATION; PNEUMOCYSTIS PNEUMONIA; RAT;

EID: 0032710064     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)80027-6     Document Type: Article

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