Functional complementation and the analysis of opioid receptor homodimerization

Molecular Pharmacology

Volumn 68, Issue 3, 2005, Pages 905-915

  Pascal, Geraldine ^a   Milligan, Graeme ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYSTEINE; DELTA OPIATE RECEPTOR; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HYBRID PROTEIN; ISOLEUCINE; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; PEPTIDE DERIVATIVE; PERTUSSIS TOXIN; SULFUR 35; VALINE;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL ANCHORAGE; CELL MEMBRANE; CELL STRAIN HEK293; CONTROLLED STUDY; DIMERIZATION; EMBRYO; GENETIC LINKAGE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTRACELLULAR SPACE; MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

BASE SEQUENCE; CELL LINE; DIMERIZATION; DIPRENORPHINE; DNA PRIMERS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; IMMUNOPRECIPITATION; RECEPTORS, OPIOID; RECOMBINANT FUSION PROTEINS;

EID: 23944451894     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.105.013847     Document Type: Article

References (38)

1. 2A-adrenoceptor. Biochemistry 37:11555-11562.
2. Bakker RA, Dees G, Carrillo JJ, Booth RG, Lopez-Gimenez JF, Milligan G, Strange PG, and Leurs R (2004) Domain swapping in the human histamine H1 receptor. J Pharmacol Exp Ther 311:131-318.
3. o1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor. Biochem J 385:197-206.
4. Breitwieser GE (2004) G protein-coupled receptor oligomerization: implications for G protein activation and cell signaling. Circ Res 94:17-27.
5. 1b-adrenoceptor. Mol Pharmacol 66:1123-1137.
6. Carrillo JJ, Pediani J, and Milligan G (2003) Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. J Biol Chem 278:42578-42587.
7. 11. J Pharmacol Exp Ther 302:1080-1088.
8. Cvejic S and Devi LA (1997) Dimerization of the delta opioid receptor: implication for a role in receptor internalization. J Biol Chem 272:26959-26964.
9. Dinger MC, Bader JE, Kobor AD, Kretzschmar AK, and Beck-Sickinger AG (2003) Homodimerization of neuropeptide y receptors investigated by fluorescence resonance energy transfer in living cells. J Biol Chem 278:10562-10571.
10. El-Asmar L, Springael JY, Ballet S, Andrieu EU, Vassart G, and Parmentier M (2005) Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers. Mol Pharmacol 67:460-469.
11. Filizola M and Weinstein H (2002) Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. Biopolymers 66:317-325.
12. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, and Palczewski K (2004) The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett 564:281-288.
13. George SR, Fan T, Xie Z, Tse R, Tam V, Varghese G, and O'Dowd BF (2000) Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. J Biol Chem 275:26128-26135.
14. i-subtypes by prolonged incubation of adipocytes with an A1 adenosine receptor agonist. J Biol Chem 265:5206-5210.
15. Hernanz-Falcon P, Rodriguez-Frade JM, Serrano A, Juan D, del Sol A, Soriano SF, Roncal F, Gomez L, Valencia A, Martinez-AC, et al. (2004) Identification of amino acid residues crucial for chemokine receptor dimerization. Nat Immunol 5:216-223.
16. Klco JM, Lassere TB, and Baranski TJ (2003) C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. J Biol Chem 278:35345-35353.
17. Lee C, Ji I, Ryu K, Song Y, Conn PM, and Ji TH (2002) Two defective heterozygous luteinizing hormone receptors can rescue hormone action. J Biol Chem 277:15795-15800.
18. Lee SP, O'Dowd BF, and George SR (2003) Homo- and hetero-oligomerization of G protein-coupled receptors. Life Sci 74:173-180.
19. Li-Wei C, Can G, De-He Z, Qiang W, Xue-Jun X, Jie C, and Zhi-Qiang C (2002) Homodimerization of human mu-opioid receptor overexpressed in Sf9 insect cells. Protein Pept Lett 9:145-152.
20. McClue SJ, Selzer E, Freissmuth M, and Milligan G (1992) Gi3 does not contribute to the inhibition of adenylate cyclase when stimulation of an alpha 2-adrenergic receptor causes activation of both Gi2 and Gi3. Biochem J 284:565-568.
21. McVey M, Ramsay D, Kellett E, Rees S, Wilson S, Pope AJ, and Milligan G (2001) Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human δ-opioid receptor displays constitutive oligomerization at the cell surface, which is not regulated by receptor occupancy. J Biol Chem 276:14092-14099.
22. i2α at fused to the human mu opioid receptor differently. J Neurochem 81:1372-1382.
23. Mercier JF, Salahpour A, Angers S, Breit A, and Bouvier M (2002) Quantitative assessment of β1- and β2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. J Biol Chem 277:44925-44931.
24. 4 receptor BLT1. J Biol Chem 279:49664-49670.
25. Milligan G (2002) The use of receptor-G protein fusion proteins for the study of ligand activity. Recept Channels 8:309-317.
26. Milligan G (2004) G protein-coupled receptor dimerization: function and ligand pharmacology. Mol Pharmacol 66:1-7.
27. Milligan G and Bouvier M (2005) Methods to monitor the quaternary structure of G protein-coupled receptors. FEBS J 272:2914-2925.
28. Milligan G, Carrillo JJ, and Pascal G (2005) Functional complementation and the analysis of GPCR dimerization, in The G Protein-Coupled Receptors Handbook (Devi LA ed) pp 267-286, Humana Press, Totowa, NJ.
29. Milligan G, Feng G-J, Ward RJ, Sartania N, Ramsay D, McLean AJ, and Carrillo JJ (2004) G protein-coupled receptor fusion proteins in drug discovery. Curr Pharm Des 10:1989-2001.
30. Molinari P, Ambrosio C, Riitano D, Sbraccia M, Gro MC, and Costa T (2003) Promiscuous coupling at receptor-Gαfusion proteins. The receptor of one covalent complex interacts with the α-subunit of another. J Biol Chem 278:15778-15788.
31. Monnot C, Bihoreau C, Conchon S, Curnow KM, Corvol P, and Clauser E (1996) Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants. J Biol Chem 271:1507-1513.
32. o1α. J Neurochem 76:1805-1813.
33. Overton MC and Blumer KJ (2002) The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J Biol Chem 277:41463-41472.
34. Pin J-P, Kniazeff J, Liu J, Binet V, Goudet C, Rondard P, and Prezeau L (2005) Allosteric functioning of dimeric class C G protein coupled receptors. FEBS J 272:2947-2955.
35. Ramsay D, Kellett E, McVey M, Rees S, and Milligan G (2002) Homo -and hetero-oligomeric interactions between G protein-coupled receptors in living cells monitored by two variants of bioluminesence resonance energy transfer. Hetero-oligomers between receptor subtypes form more efficiency than between less closely related sequences. Biochem J 365:429-440.
36. Stanasila L, Perez JB, Vogel H, and Cotecchia S (2003) Oligomerization of the α1a and α1b-adrenergic receptor subtypes. Potential implications in receptor internalization. J Biol Chem 278:40239-40251.
37. 11α is not required for interaction with β/γ complex J Biol Chem 276:35883-35890.
38. i1α. Cell Signalling 14:139-144.