Activation of an α2A-adrenoceptor-Gαo1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor

Biochemical Journal

Volumn 385, Issue 1, 2005, Pages 197-206

  Barclay, Elaine ^a   O'Reilly, Mark ^b   Milligan, Graeme ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Acylation; G protein; G protein coupled receptor (GPCR); Signal transduction

Indexed keywords

ACYLATION; BIOCHEMISTRY; CHEMICAL ACTIVATION; REACTION KINETICS;

ADRENALINE; FUSION PROTEINS; LIGAND BINDING; PALMITOYLATION; POST-TRANSLATIONAL ACYLATION;

PROTEINS;

ADRENALIN; ALPHA 2A ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HYBRID PROTEIN; ALPHA 2 ADRENERGIC RECEPTOR; GUANOSINE TRIPHOSPHATE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; PALMITIC ACID DERIVATIVE;

ARTICLE; BINDING AFFINITY; HUMAN; HUMAN CELL; LIGAND BINDING; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; REACTION ANALYSIS; SIGNAL TRANSDUCTION; ACYLATION; CELL LINE; DOSE RESPONSE; GENETICS; KINETICS; METABOLISM; MUTATION;

ACYLATION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE TRIPHOSPHATE; HUMANS; KINETICS; LIGANDS; MUTATION; PALMITATES; RECEPTORS, ADRENERGIC, ALPHA-2; RECOMBINANT FUSION PROTEINS;

EID: 12744274770     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041432     Document Type: Article

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