A selective human H4-receptor agonist: (-)-2-Cyano-1-methyl-3-{(2R,5R)-5[1H-imidazol-4(5)-yl] tetrahydrofuran-2-yl}methylguanidine

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 3162-3165

  Hashimoto, Takeshi ^a   Harusawa, Shinya ^c   Araki, Lisa ^c   Zuiderveld, Obbe P ^b   Smit, Martine J ^b   Imazu, Tomonari ^c   Takashima, Seiichiroh ^c   Yamamoto, Yumiko ^a   Sakamoto, Yasuhiko ^d   Kurihara, Takushi ^c   Leurs, Rob ^b   Bakker, Remko A ^b   Yamatodani, Atsushi ^e  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c OSAKA MEDICAL COLLEGE   (Japan)

^d Azwell Inc   (Japan)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 1 METHYL 3 [5 [1H IMIDAZOL 4(5) YL]TETRAHYDROFURAN 2 YL]METHYLGUANIDINE; HISTAMINE AGONIST; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

BINDING, COMPETITIVE; CELL LINE; HISTAMINE AGONISTS; HUMANS; IMIDAZOLES; METHYLGUANIDINE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H3; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038121693     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0300025     Document Type: Article

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