Inhibition and regression of atherosclerotic lesions

Acta Biochimica Polonica

Volumn 52, Issue 2, 2005, Pages 311-319

  Oka, Kazuhiro ^a   Chan, Lawrence ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b St Luke's Episcopal Hospital   (United States)

Author keywords

Atherosclerosis; Gene therapy; Helper dependent adenovirus; Inflammation; Inhibition of lesion progression; Lesion regression

Indexed keywords

ADENOVIRIDAE; ANIMALIA;

EID: 23644449721     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.2005_3444     Document Type: Conference Paper

References (67)

1. Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinckerhoff CE, Sukhova GK, Libby P (1998a) Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Circulation 97: 2433-2444.
2. Aikawa M, Rabkin E, Voglic SJ, Shing H, Nagai R, Schoen FJ, Libby P (1998b) Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma. Circ Res 83: 1015-1026.
3. Aikawa M, Voglic SJ, Sugiyama S, Rabkin E, Taubman MB, Fallon JT, Libby P (1999) Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. Circulation 100: 1215-1222.
4. Armstrong ML, Megan MB (1975) Arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets. Circ Res 36: 256-261.
5. Belalcazar LM, Merched A, Carr B, Oka K, Chen KH, Pastore L, Beaudet A, Chan L (2003) Long-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia. Circulation 107: 2726-2732.
6. Blankenberg S, Barbaux S, Tiret L (2003) Adhesion molecules and atherosclerosis. Atherosclerosis 170: 191-203.
7. Boring L, Gosling J, Cleary M, Charo IF (1998) Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394: 894-897.
8. Brunetti-Pierri N, Palmer DJ, Beaudet AL, Carey KD, Finegold M, Ng P (2004) Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates. Hum Gene Ther 15: 35-46.
9. Burger C, Gorbatyuk OS, Velardo MJ, Peden CS, Williams P, Zolotukhin S, Reier PJ, Mandel RJ, Muzyczka N (2004) Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol Ther 10: 302-317.
10. Chen SJ, Rader DJ, Tazelaar J, Kawashiri M, Gao G, Wilson JM (2000) Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expressing very-low-density lipoprotein receptor. Mol Ther 2: 256-261.
11. Clinton SK, Underwood R, Hayes L, Sherman ML, Kufe DW, Libby P (1992) Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis. Am J Pathol 140: 301-316.
12. Davignon J (2005) Apolipoprotein E and atherosclerosis: beyond lipid effect. Arterioscler Thromb Vasc Biol 25: 267-269.
13. Desurmont C, Caillaud JM, Emmanuel F, Benoit P, Fruchart JC, Castro G, Branellec D, Heard JM, Duverger N (2000) Complete atherosclerosis regression after human ApoE gene transfer in ApoE-deficient/nude mice. Arterioscler Thromb Vasc Biol 20: 435-442.
14. Duan D, Yue Y, Yan Z, Engelhardt JF (2000) A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation. Nat Med 6: 595-598.
15. Gao GP, Alvira MR, Wang L, Calcedo R, Johnston J, Wilson JM (2002) Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc Natl Acad Sci USA 99: 11854-11859.
16. Glass CK, Witztum JL (2001) Atherosclerosis. the road ahead. Cell 104: 503-516.
17. Grimm D, Kay MA, Kleinschmidt JA (2003) Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6. Mol Ther 7: 839-850.
18. Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, Rollins BJ (1998) Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell 2: 275-281.
19. Hansson GK (2001) Immune mechanisms in atherosclerosis. Arterioscler Thromb Vasc Biol 21: 1876-1890.
20. Harris JD, Graham IR, Schepelmann S, Stannard AK, Roberts ML, Hodges BL, Hill V, Amalfitano A, Hassall DG, Owen JS, Dickson G (2002) Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE. Hum Mol Genet 11: 43-58.
21. Hoffman M, Blum A, Baruch R, Kaplan E, Benjamin M (2004) Leukocytes and coronary heart disease. Atherosclerosis 172: 1-6.
22. Hopkins PN (2003) Familial hypercholesterolemia - improving treatment and meeting guidelines. Int J Cardiol 89: 13-23.
23. Ishibashi S, Inaba T, Shimano H, Harada K, Inoue I, Mokuno H, Mori N, Gotoda T, Takaku F, Yamada N (1990) Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages. J Biol Chem 265: 14109-14117.
24. Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J (1993) Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92: 883-893.
25. Karnik SK, Brooke BS, Bayes-Genis A, Sorensen L, Wythe JD, Schwartz RS, Keating MT, Li DY (2003) A critical role for elastin signaling in vascular morphogenesis and disease. Development 130: 411-423.
26. Kawashiri M, Zhang Y, Usher D, Reilly M, Pure E, Rader DJ (2001) Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice. J Lipid Res 42: 943-950.
27. Kawashiri MA, Zhang Y, Pure E, Rader DJ (2002) Combined effects of cholesterol reduction and apolipoprotein A-I expression on atherosclerosis in LDL receptor deficient mice. Atherosclerosis 165: 15-22.
28. Kim IH, Jozkowicz A, Piedra PA, Oka K, Chan L (2001) Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci USA 98: 13282-13287.
29. Kochanek S (1999) High-capacity adenoviral vectors for gene transfer and somatic gene therapy. Hum Gene Ther 10: 2451-2459.
30. Kockx MM, De Meyer GR, Buyssens N, Knaapen MW, Bult H, Herman AG (1998) Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal. Circ Res 83: 378-387.
31. Kozarsky KF, Mckinley DR, Austin LL, Raper SE, Stratford-Perricaudet LD, Wilson JM (1994) In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J Biol Chem 269: 13695-13702.
32. Kozarsky KF, Jooss K, Donahee M, Strauss JF 3rd, Wilson JM (1996) Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat Genet 13: 54-62.
33. Lebherz C, Gao G, Louboutin J, Millar J, Rader DJ, Wilson J (2003) AAV2/7 and AAV2/8 mediated liver directed gene therapy enables long-term expression of the human LDL receptor and substantially diminishes atherosclerosis in LDL receptor deficient mice. Circulation 108: IV-143.
34. Li J, Fang B, Eisensmith RC, Li XH, Nasonkin I, Lin-Lee YC, Mims MP, Hughes A, Montgomery CD, Roberts JD, Et Al (1995) In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene. J Clin Invest 95: 768-773.
35. Libby P (2002) Inflammation in atherosclerosis. Nature 420: 868-874.
36. Libby P, Aikawa M (2001) Evolution and stabilization of vulnerable atherosclerotic plaques. Jpn Circ J 65: 473-479.
37. Libby P, Aikawa M (2002) Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nat Med 8: 1257-1262.
38. Llodra J, Angeli V, Liu J, Trogan E, Fisher EA, Randolph GJ (2004) Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. Proc Natl Acad Sci USA 101: 11779-11784.
39. McCarty DM, Young SM Jr, Samulski RJ (2004) Integration of adeno-associated virus (AAV) and recombinant AAV vectors. Annu Rev Genet 38: 819-845.
40. Meir KS, Leitersdorf E (2004) Atherosclerosis in the apolipoprotein-E- deficient mouse: a decade of progress. Arterioscler Thromb Vasc Biol 24: 1006-1014.
41. Mertens A, Verhamme P, Bielicki JK, Phillips MC, Quarck R, Verreth W, Stengel D, Ninio E, Navab M, Mackness B, Mackness M, Holvoet P (2003) Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis. Circulation 107: 1640-1646.
42. Muruve DA, Cotter MJ, Zaiss AK, White LR, Liu Q, Chan T, Clark SA, Ross PJ, Meulenbroek RA, Maelandsmo GM, Parks RJ (2004) Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo. J Virol 78: 5966-5972.
43. Nakai H, Fuess S, Storm TA, Muramatsu S, Nara Y, Kay MA (2005) Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice. J Virol 79: 214-224.
44. Naoumova RP, Thompson GR, Soutar AK (2004) Current management of severe homozygous hypercholesterolaemias. Curr Opin Lipidol 15: 413-422.
45. Nilsson J, Hansson GK, Shah PK (2005) Immunomodulation of atherosclerosis: implications for vaccine development. Arterioscler Thromb Vasc Biol 25: 18-28.
46. Nomura S, Merched A, Nour E, Dieker C, Oka K, Chan L (2004) Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia. Gene Ther 11: 1540-1548.
47. Oka K, Chan L (2002) Recent advances in liver-directed gene therapy for dyslipidemia. Curr Atheroscler Rep 4: 199-207.
48. Oka K, Chan L (2004) Liver-directed gene therapy for dyslipidemia and diabetes. Curr Atheroscler Rep 6: 203-209.
49. Oka K, Pastore L, Kim IH, Merched A, Nomura S, Lee HJ, Merched-Sauvage M, Arden-Riley C, Lee B, Finegold M, Beaudet A, Chan L (2001) Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor. Circulation 103: 1274-1281.
50. Pastore L, Belalcazar LM, Oka K, Cela R, Lee B, Chan L, Beaudet AL (2004) Helper-dependent adenoviral vector-mediated long-term expression of human apolipoprotein A-I reduces atherosclerosis in apo E-deficient mice. Gene 327: 153-160.
51. Polansky H (2003). Microcompetition with Foreign DNA and the Origin of Chronic Disease. The Center for the Biology and Chronic Disease. Rochester.
52. Raffai RL, Loeb SM, Weisgraber KH (2005) Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels. Arterioscler Thromb Vasc Biol 25: 436-441.
53. Reis ED, Li J, Fayad ZA, Rong JX, Hansoty D, Aguinaldo JG, Fallon JT, Fisher EA (2001) Dramatic remodeling of advanced atherosclerotic plaques of the apolipoprotein Å-deficient mouse in a novel transplantation model. J Vasc Surg 34: 541-547.
54. Rosenfeld ME, Polinsky P, Virmani R, Kauser K, Rubanyi G, Schwartz SM (2000) Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse. Arterioscler Thromb Vasc Biol 20: 2587-2592.
55. Sarkar R, Tetreault R, Gao G, Wang L, Bell P, Chandler R, Wilson JM, Kazazian HH Jr (2004) Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype. Blood 103: 1253-1260.
56. Schiedner G, Hertel S, Johnston M, Dries V, Van Rooijen N, Kochanek S (2003) Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors. Mol Ther 7: 35-43.
57. Schnell MA, Zhang Y, Tazelaar J, Gao GP, Yu Q C, Qian R, Chen SJ, Varnavski AN, Leclair C, Raper SE, Wilson JM (2001) Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther 3: 708-722.
58. Shah PK (2002) Low-density lipoprotein lowering and atherosclerosis progression: does more mean less? Circulation 106: 2039-2040.
59. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 92: 1355-1374.
60. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W Jr, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, Wissler RW (1994) A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb 14: 840-856.
61. Tangirala RK, Pratico D, Fitzgerald GA, Chun S, Tsukamoto K, Maugeais C, Usher DC, Pure E, Rader DJ (2001) Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E. J Biol Chem 276: 261-266.
62. Tangirala RK, Tsukamoto K, Chun SH, Usher D, Pure E, Rader DJ (1999) Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice. Circulation 100: 1816-1822.
63. Thomas CE, Ehrhardt A, Kay MA (2003) Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 4: 346-358.
64. Tsukamoto K, Tangirala R, Chun SH, Pure E, Rader DJ (1999) Rapid regression of atherosclerosis induced by liver-directed gene transfer of ApoE in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19: 2162-2170.
65. Tsukamoto K, Tangirala RK, Chun S, Usher D, Pure E, Rader DJ (2000) Hepatic expression of apolipoprotein E inhibits progression of atherosclerosis without reducing cholesterol levels in LDL receptor-deficient mice. Mol Ther 1: 189-194.
66. Verhamme P, Quarck R, Hao H, Knaapen M, Dymarkowski S, Bernar H, Van Cleemput J, Janssens S, Vermylen J, Gabbiani G, Kockx M, Holvoet P (2002) Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigs. Cardiovasc Res 56: 135-144.
67. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 20: 1262-1275.