Mechanism of poly(acrylic acid) acceleration of antithrombin inhibition of thrombin: Implications for the design of novel heparin mimics

Journal of Medicinal Chemistry

Volumn 48, Issue 16, 2005, Pages 5360-5368

  Monien, Bernhard H ^a   Cheang, Kai I ^a   Desai, Umesh R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; CARBOXYLIC ACID; HEPARIN; PENTASACCHARIDE; POLYACRYLIC ACID; POLYSACCHARIDE; THROMBIN; THROMBIN INHIBITOR;

ACID BASE BALANCE; ANTICOAGULANT THERAPY; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPETITIVE INHIBITION; COMPLEX FORMATION; DRUG MECHANISM; IONIC STRENGTH; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PROTEIN FAMILY; REACTION ANALYSIS;

ACRYLIC RESINS; ANTITHROMBINS; BINDING SITES; BINDING, COMPETITIVE; CARBOHYDRATE SEQUENCE; ELECTROSTATICS; HEPARIN; ION EXCHANGE; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; THROMBIN;

EID: 23444440178     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0503648     Document Type: Article

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