Synthesis of heparin-like antithrombotics having perphosphorylated thrombin binding domains

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 9, 1999, Pages 1881-1890

  Buijsman, Rogier C ^a   Basten, Jan E M ^b   Dreef Tromp, Cornelia M ^b   Van Der Marel, Gijsbert A ^a   Van Boeckel, Constant A A ^b   Van Boom, Jacques H ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NV ORGANON   (Netherlands)

Author keywords

Antithrombotics; Enzyme inhibitor; Heparin; Oligosaccharides; Thrombin

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN III; CELLOBIOSE DERIVATIVE; HEPARIN DERIVATIVE; MOLTOTRIOSE DERIVATIVE; THROMBIN BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONJUGATION; DRUG POTENCY; DRUG SYNTHESIS; HEPARINIZATION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; THROMBIN TIME;

ANTITHROMBINS; BINDING SITES; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; HEPARIN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; THROMBIN;

EID: 0032884766     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00139-X     Document Type: Article

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