The oligosaccharide side chain on Asn-135 of α-antithrombin, absent in β-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change

Biochemistry

Volumn 36, Issue 22, 1997, Pages 6682-6691

  Turk, Boris ^a,c   Brieditis, Ingrid ^c   Bock, Susan C ^b,d   Olson, Steven T ^e   Björk, Ingemar ^c  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; HEPARIN; OLIGOSACCHARIDE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BLOOD CLOTTING; COMPLEX FORMATION; DRUG PROTEIN BINDING; FIBRINOLYSIS; HUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ANTITHROMBIN III; ASPARAGINE; BINDING SITES; FACTOR XA; GLYCOSYLATION; HEPARIN; HUMANS; KINETICS; OLIGOSACCHARIDES; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 0030917184     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9702492     Document Type: Article

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