HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 31, 2005, Pages 11017-11022

  Drakesmith, Hal ^a   Chen, Nan ^a   Ledermann, Hannah ^a   Screaton, Gavin ^a,b   Townsend, Alain ^a   Xu, Xiao Ning ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

AIDS; Macrophages; MHC I

Indexed keywords

FERRITIN; GAG PROTEIN; HFE PROTEIN; IRON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN; PROLINE; PROTEIN TYROSINE KINASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; EMBRYO; ENZYME BINDING; EX VIVO STUDY; GOLGI COMPLEX; HEMOCHROMATOSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNITY; IRON METABOLISM; MACROPHAGE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REDUCTION; STRUCTURE ANALYSIS; VIROGENESIS; WILD TYPE;

BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; DOWN-REGULATION; GENE PRODUCTS, NEF; GENES, NEF; HELA CELLS; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV INFECTIONS; HIV-1; HOMEOSTASIS; HUMANS; IRON; MACROPHAGES; MEMBRANE PROTEINS; MONOCYTES; MUTATION; PROTEIN STRUCTURE, TERTIARY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 23344446043     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0504823102     Document Type: Article

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