A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells

Current Biology

Volumn 11, Issue 16, 2001, Pages 1294-1299

  Fackler, Oliver T ^b   Wolf, Dietlinde ^a   Weber, H Oliver ^a   Laffert, Bernd ^a   D'Aloja, Paola ^a   Schuler Thurner, Beatrice ^a   Geffin, Rebeca ^d   Saksela, Kalle ^e   Geyer, Matthias ^c   Peterlin, B Matija ^c   Schuler, Gerold ^a   Baur, Andreas S ^d  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF TAMPERE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035928809     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00373-6     Document Type: Article

References (27)

1. Importance of the nef gene for maintenance of high virus loads and for development of AIDS
2. Brief report: Absence of intact nef sequences in a long-term nonprogressive HIV-1 infection
3. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
4. The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cells and T cells
5. Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1
6. Functional and structural defects in HIV type 1 nef genes derived from pediatric long-term survivors
7. Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors
8. Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cells
9. Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells
10. gag, vif, and nef genes contribute to the homologous viral interference induced by a nonproducer human immunodeficiency virus type 1 (HIV-1) variant: Identification of novel HIV-1-inhibiting viral protein mutants
11. Interactions between HIV-1 Nef and vacuolar ATPase facilitate the internalization of CD4
12. Identification of the Nef-associated kinase as p21-activated kinase 2
13. p21-activated kinase 1 plays a critical role in cellular activation by Nef
14. Human immunodeficieny virus type I genome activation induced by human T-cell leukemia virus type I Tax protein is through cooperation of NF-κB and Tat
15. The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase
16. SH3-domain binding function of HIV-1 Nef is required for association with a PAK-related kinase
17. The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent
18. Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain
19. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
20. Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity
21. Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein
22. The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
23. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling
24. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
25. The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surfae by NMR
26. Conformational substrates in proteins
27. The Nef protein of HIV-1 associates with rafts and primes T cells for activation