Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation

European Journal of Immunology

Volumn 31, Issue 8, 2001, Pages 2382-2387

  Chang, Alex H ^a,b   O'Shaughnessy, Michael V ^b,c,d   Jirik, Frank R ^a,b,c,d  

^a CHILDREN S AND WOMEN S HEALTH CENTRE OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c ST PAUL S HOSPITAL   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

Hck; HIV 1; MHC class I; Nef; Src homology 3

Indexed keywords

CELL PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MUTANT PROTEIN; NEF PROTEIN; PROLINE; PROTEIN TYROSINE KINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CELL ACTIVITY; CELL KILLING; CELL SPECIFICITY; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INHIBITION KINETICS; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; MODEL; MUTANT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; VIRUS REPLICATION;

ANTIGENS, CD4; BINDING SITES; BLOTTING, WESTERN; CELL LINE; DOWN-REGULATION; FLOW CYTOMETRY; GENE PRODUCTS, NEF; GENES, DOMINANT; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV-1; HUMANS; MUTATION; PEPTIDES; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-HCK; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 0034850529     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200108)31:8<2382::AID-IMMU2382>3.0.CO;2-K     Document Type: Article

References (35)

1. Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
2. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
3. The down-regulation of CD4 and MHC-I by primate lentiviruses: A paradigm for the modulation of cell surface receptors
4. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis
5. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 down-regulation
6. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell
7. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
8. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling
9. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
10. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene
11. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
12. The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane
13. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
14. Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for down-regulation of cell surface CD4
15. Nef-induced CD4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes
16. Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules
17. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
18. + viruses but not for down-regulation of CD4
19. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
20. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein
21. Inhibition of human immunodeficiency virus type 1 virion entry by dominant-negative Hck
22. Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking
23. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling
24. SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1
25. Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T cell signaling defects
26. Dissociation of the CD4 down-regulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef
27. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
28. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
29. Towards a consensus for a role of Nef in both viral replication and immunomodulation?
30. Antigen processing and presentation by the class I major histocompatibility complex
31. The selective down-regulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
32. HIV's evasion of the cellular immune response
33. Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo
34. Modifications of vectors pEF-BOS, pcDNA1 and pcDNA3 result in improved convenience and expression
35. Construction of single-chain antibodies that bind an overlapping epitope of HIV-1 Nef