Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 31, 2005, Pages 10970-10975

  Murali, Ramachandran ^a,b   Cheng, Xin ^a   Berezov, Alan ^a   Du, Xiulian ^a   Schön, Arnie ^c   Freire, Ernesto ^c   Xu, Xiaowei ^a   Chen, Youhai H ^a   Greene, Mark I ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Allosteric; Arthritis; Drug design; Inhibitor; Structure

Indexed keywords

COLLAGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; TRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG DESIGN; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

ALLOSTERIC SITE; AMINO ACID SUBSTITUTION; ANIMALS; ARTHRITIS, EXPERIMENTAL; BASE SEQUENCE; CELL LINE; DNA; HUMANS; MALE; MICE; MICE, INBRED DBA; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN CONFORMATION; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TRYPTOPHAN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 23344443800     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0504301102     Document Type: Article

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