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Volumn 40, Issue 2, 1997, Pages 193-204

Allosteric binding sites on muscarinic receptors

Author keywords

Alcuronium; Allosteric; Cooperativity; Gallamine; Muscarinic receptors

Indexed keywords

ACETYLCHOLINE; ALCURONIUM; GALLAMINE; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROMUSCULAR BLOCKING AGENT; OBIDOXIME; RECEPTOR SUBTYPE; STRYCHNINE; TUBOCURARINE CHLORIDE;

EID: 0031009786     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199702)40:2<193::AID-DDR9>3.0.CO;2-G     Document Type: Review
Times cited : (72)

References (74)
  • 1
    • 0017107977 scopus 로고
    • A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C
    • Barlow RB, Berry KJ, Glenton PA, Nilolaou NM, Soh KS (1976): A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C. Br J Pharmacol 58:613-620.
    • (1976) Br J Pharmacol , vol.58 , pp. 613-620
    • Barlow, R.B.1    Berry, K.J.2    Glenton, P.A.3    Nilolaou, N.M.4    Soh, K.S.5
  • 2
    • 0016610675 scopus 로고
    • Are muscarinic receptors in the central and peripheral nervous system different?
    • Beld AJ, Van den Hoven S, Wouterse AC, Zegers MAP (1975): Are muscarinic receptors in the central and peripheral nervous system different? Eur J Pharmacol 30:360-363.
    • (1975) Eur J Pharmacol , vol.30 , pp. 360-363
    • Beld, A.J.1    Van Den Hoven, S.2    Wouterse, A.C.3    Zegers, M.A.P.4
  • 5
    • 0028334668 scopus 로고
    • Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors
    • Botero Cid MH, Holzgrabe U, Kostenis E, Mohr K, Trankle C (1994): Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors. J Med Chem 37:1439-1445.
    • (1994) J Med Chem , vol.37 , pp. 1439-1445
    • Botero Cid, M.H.1    Holzgrabe, U.2    Kostenis, E.3    Mohr, K.4    Trankle, C.5
  • 7
    • 0030060858 scopus 로고    scopus 로고
    • Constitutive activation of chimeric m2/m5 muscarinic receptors and delineation of G-protein coupling selectivity domains
    • Burstein ES, Spalding TA, Brann MR (1996): Constitutive activation of chimeric m2/m5 muscarinic receptors and delineation of G-protein coupling selectivity domains. Biochem Pharmacol 51:539-544.
    • (1996) Biochem Pharmacol , vol.51 , pp. 539-544
    • Burstein, E.S.1    Spalding, T.A.2    Brann, M.R.3
  • 8
    • 0013945471 scopus 로고
    • Responses of acetylcholinesterase from Torpedo mannorata to salts and curarising agents
    • Changeux J-P (1966): Responses of acetylcholinesterase from Torpedo mannorata to salts and curarising agents. Mol Pharmacol 2:369-392.
    • (1966) Mol Pharmacol , vol.2 , pp. 369-392
    • Changeux, J.-P.1
  • 9
    • 0021997664 scopus 로고
    • The interaction of McN-A-343 with pirenzepine and other selective muscarine receptor antagonists at a prejunctional muscarine receptor
    • Choo LK, Mitchelson F, Vong YM (1985): The interaction of McN-A-343 with pirenzepine and other selective muscarine receptor antagonists at a prejunctional muscarine receptor. Naunyn-Schmiedebergs Arch Pharmacol 328:430-438.
    • (1985) Naunyn-Schmiedebergs Arch Pharmacol , vol.328 , pp. 430-438
    • Choo, L.K.1    Mitchelson, F.2    Vong, Y.M.3
  • 10
    • 0017105216 scopus 로고
    • The inhibitory effect of gallamine on muscarinic receptors
    • Clark AL, Mitchelson F (1976): The inhibitory effect of gallamine on muscarinic receptors. Br J Pharmacol 58:323-331.
    • (1976) Br J Pharmacol , vol.58 , pp. 323-331
    • Clark, A.L.1    Mitchelson, F.2
  • 11
    • 0021866920 scopus 로고
    • Batrachotoxin changes the properties of the muscarinic receptor in rat brain and heart: Possible interactions between niuscarinic receptors and sodium channels
    • Cohen-Armon M, Kloog Y, Henis YI, Sokolovsky M (1985): Batrachotoxin changes the properties of the muscarinic receptor in rat brain and heart: Possible interactions between niuscarinic receptors and sodium channels. Proc Natl Acad Sci USA 82:3524-3527.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 3524-3527
    • Cohen-Armon, M.1    Kloog, Y.2    Henis, Y.I.3    Sokolovsky, M.4
  • 13
    • 0020574987 scopus 로고
    • Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium
    • Dunlap J, Brown JH (1983): Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium. Mol Pharmacol 24:15-22.
    • (1983) Mol Pharmacol , vol.24 , pp. 15-22
    • Dunlap, J.1    Brown, J.H.2
  • 14
    • 0022541659 scopus 로고
    • "Inverse agonists," cooperativity and drug action at benzodiazepine receptors
    • Ehlert FJ (1986): "Inverse agonists," cooperativity and drug action at benzodiazepine receptors. Trends Pharmacol Sci 7:28-32.
    • (1986) Trends Pharmacol Sci , vol.7 , pp. 28-32
    • Ehlert, F.J.1
  • 15
    • 0023958554 scopus 로고
    • Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods
    • Ehlert FJ (1988a): Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. Mol Pharmacol 33:187-104.
    • (1988) Mol Pharmacol , vol.33 , pp. 187-1104
    • Ehlert, F.J.1
  • 16
    • 0023794328 scopus 로고
    • Gallamine allosterically antagonizes muscarinic receptor-mediated inhibition of adenylate cyclase activity in the rat myocardium
    • Ehlert FJ (1988b): Gallamine allosterically antagonizes muscarinic receptor-mediated inhibition of adenylate cyclase activity in the rat myocardium. J Pharmacol Exp Ther 247:596-602.
    • (1988) J Pharmacol Exp Ther , vol.247 , pp. 596-602
    • Ehlert, F.J.1
  • 18
    • 0019941140 scopus 로고
    • Competitive interaction of gallamine with multiple muscarinic receptors
    • Ellis J, Hoss W (1982): Competitive interaction of gallamine with multiple muscarinic receptors. Biochem Pharmacol 31:873-876.
    • (1982) Biochem Pharmacol , vol.31 , pp. 873-876
    • Ellis, J.1    Hoss, W.2
  • 19
    • 0027054955 scopus 로고
    • Two allosteric modulators interact at a common site on cardiac muscarinic receptors
    • Ellis J, Seidenberg M (1992): Two allosteric modulators interact at a common site on cardiac muscarinic receptors. Mol Pharmacol 42:638-641.
    • (1992) Mol Pharmacol , vol.42 , pp. 638-641
    • Ellis, J.1    Seidenberg, M.2
  • 20
    • 0026005728 scopus 로고
    • Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes
    • Ellis J, Huyler J, Brann MR (1991): Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes. Biochem Pharmacol 42:1927-1932.
    • (1991) Biochem Pharmacol , vol.42 , pp. 1927-1932
    • Ellis, J.1    Huyler, J.2    Brann, M.R.3
  • 21
    • 0027172276 scopus 로고
    • Use of chimeric muscarinic receptors to investigate epitopes involved in allosteric interactions
    • Ellis J, Seidenberg M, Brann MR (1993): Use of chimeric muscarinic receptors to investigate epitopes involved in allosteric interactions. Mol Pharmacol 44:583-588.
    • (1993) Mol Pharmacol , vol.44 , pp. 583-588
    • Ellis, J.1    Seidenberg, M.2    Brann, M.R.3
  • 22
    • 0024847889 scopus 로고
    • Site-directed mutagenesis of ml muscarinic acetylcholine receptors: Conserved aspartic acids play important roles in receptor function
    • Fraser CM, Wang CD, Robinson DA, Gocayne JD, Venter JC (1989): Site-directed mutagenesis of ml muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function. Mol Pharmacol 36:840-847.
    • (1989) Mol Pharmacol , vol.36 , pp. 840-847
    • Fraser, C.M.1    Wang, C.D.2    Robinson, D.A.3    Gocayne, J.D.4    Venter, J.C.5
  • 23
    • 0026980011 scopus 로고
    • Heparin, dextran and trypan blue allosterically modulate M2 muscarinic receptor binding properties and interfere with receptor-mediated inhibition of adenylate cyclase
    • Gerstin EH, Jr.. LuongT, Ehlert FJ (1992): Heparin, dextran and trypan blue allosterically modulate M2 muscarinic receptor binding properties and interfere with receptor-mediated inhibition of adenylate cyclase. J Pharmacol Exp Ther 263:910-917.
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 910-917
    • Gerstin, E.H.1    Luongt, J.2    Ehlert, F.J.3
  • 25
    • 0030582833 scopus 로고    scopus 로고
    • 3H]acetylcholine to m2 muscarinic receptors
    • 3H]acetylcholine to m2 muscarinic receptors. Biochem Pharmacol 52:1767-1775.
    • (1996) Biochem Pharmacol , vol.52 , pp. 1767-1775
    • Gnagey, A.1    Ellis, J.2
  • 26
    • 0018835992 scopus 로고
    • Pirenzepine distinguishes between different subclasses of muscarinic receptors
    • Hammer R, Berrie CP, Birdsall NJ, Burgen AS, Hulme EC (1980): Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature 283:90-92.
    • (1980) Nature , vol.283 , pp. 90-92
    • Hammer, R.1    Berrie, C.P.2    Birdsall, N.J.3    Burgen, A.S.4    Hulme, E.C.5
  • 28
    • 0002913518 scopus 로고
    • Allosteric interactions of muscarinic receptors and their regulation by other membrane proteins
    • Brown JH (ed): Humana Press, Clifton, NJ
    • Henis YI, Kloog Y, Sokolovsky M (1989): Allosteric interactions of muscarinic receptors and their regulation by other membrane proteins. In Brown JH (ed): The Muscarinic Receptors. Humana Press, Clifton, NJ, pp 377-418.
    • (1989) The Muscarinic Receptors , pp. 377-418
    • Henis, Y.I.1    Kloog, Y.2    Sokolovsky, M.3
  • 29
    • 0028007135 scopus 로고
    • A kinetic model for oxotremorine M binding to recombinant porcine m2 muscarinic receptors expressed in Chinese hamster ovary cells
    • Hirschberg BT, Schimerlik MI (1994): A kinetic model for oxotremorine M binding to recombinant porcine m2 muscarinic receptors expressed in Chinese hamster ovary cells. J Biol Chem 269:26127-26135.
    • (1994) J Biol Chem , vol.269 , pp. 26127-26135
    • Hirschberg, B.T.1    Schimerlik, M.I.2
  • 30
    • 0027449275 scopus 로고
    • Allosteric interaction of dynorphin and myelin basic protein with muscarinic receptors
    • Hu J, El-Fakahany EE (1993): Allosteric interaction of dynorphin and myelin basic protein with muscarinic receptors. Pharmacol 47:351-359.
    • (1993) Pharmacol , vol.47 , pp. 351-359
    • Hu, J.1    El-Fakahany, E.E.2
  • 31
    • 0027065042 scopus 로고
    • Complex allosteric modulation of cardiac muscarinic receptors by protamine: Potential model for putative endogenous ligands
    • Hu J, Wang SZ, Forray C, El-Fakahany EE (1992): Complex allosteric modulation of cardiac muscarinic receptors by protamine: Potential model for putative endogenous ligands. .Mol Pharmacol 42:311-321.
    • (1992) Mol Pharmacol , vol.42 , pp. 311-321
    • Hu, J.1    Wang, S.Z.2    Forray, C.3    El-Fakahany, E.E.4
  • 34
    • 0016017937 scopus 로고
    • Antiacetylcholine drugs: Chemistry, stereochemistry, and pharmacology
    • Inch TD, Brimblecomb RW (1974): Antiacetylcholine drugs: Chemistry, stereochemistry, and pharmacology. Int Rev Neurobiol 16:67-144.
    • (1974) Int Rev Neurobiol , vol.16 , pp. 67-144
    • Inch, T.D.1    Brimblecomb, R.W.2
  • 35
    • 0027232088 scopus 로고
    • Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor
    • Jacoby DB, Gleich GJ, Fryer AD (1993): Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor. J Clin Invest 91:1314-1318.
    • (1993) J Clin Invest , vol.91 , pp. 1314-1318
    • Jacoby, D.B.1    Gleich, G.J.2    Fryer, A.D.3
  • 36
    • 0028116121 scopus 로고
    • Protection by alcuronium of muscarinic receptors against chemical inactivation and location of the allosteric binding site for alcuronium
    • Jakubik J, Tucek S (1994): Protection by alcuronium of muscarinic receptors against chemical inactivation and location of the allosteric binding site for alcuronium. J Neurochem 63:1932-1940.
    • (1994) J Neurochem , vol.63 , pp. 1932-1940
    • Jakubik, J.1    Tucek, S.2
  • 37
    • 0029417130 scopus 로고
    • Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists
    • Jakubik J, Bacakova L, El-Fakahany EE, Tucek S (1995): Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists. FEBS Lett 377:275-279.
    • (1995) FEBS Lett , vol.377 , pp. 275-279
    • Jakubik, J.1    Bacakova, L.2    El-Fakahany, E.E.3    Tucek, S.4
  • 38
  • 39
    • 0027973761 scopus 로고
    • Toxins from mamba venoms: Small proteins with selectivities for different subtypes of muscarinic receptors
    • Jerusalinsky D, Harvey AL (1994): Toxins from mamba venoms: Small proteins with selectivities for different subtypes of muscarinic receptors. Trends Pharmacol Sci 15:424-430.
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 424-430
    • Jerusalinsky, D.1    Harvey, A.L.2
  • 41
    • 0029976454 scopus 로고    scopus 로고
    • Receptor conformation induction versus selection - All part of the same energy landscape
    • Kenakin T (1996): Receptor conformation induction versus selection - all part of the same energy landscape. Trends Pharmacol Sci 17:190-191.
    • (1996) Trends Pharmacol Sci , vol.17 , pp. 190-191
    • Kenakin, T.1
  • 42
    • 0024446412 scopus 로고
    • Pharmacologic discrimination between receptor heterogeneity and allosteric interaction: Resultant analysis of gallamine and pirenzepine antagonism of muscarinic responses in rat trachea
    • Kenakin T, Boselli C (1989): Pharmacologic discrimination between receptor heterogeneity and allosteric interaction: Resultant analysis of gallamine and pirenzepine antagonism of muscarinic responses in rat trachea. J Pharmacol Exp Ther 250:944-952.
    • (1989) J Pharmacol Exp Ther , vol.250 , pp. 944-952
    • Kenakin, T.1    Boselli, C.2
  • 43
    • 0027051787 scopus 로고
    • Tissue response as a functional discriminator of receptor heterogeneity: Effects of mixed receptor populations on Schild regressions
    • Kenakin TP (1992): Tissue response as a functional discriminator of receptor heterogeneity: Effects of mixed receptor populations on Schild regressions. Mol Pharmacol 41:699-707.
    • (1992) Mol Pharmacol , vol.41 , pp. 699-707
    • Kenakin, T.P.1
  • 44
    • 0026592357 scopus 로고
    • Constitutive activation of the alpha IB-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation
    • Kjelsberg MA, Cotecchia S, Ostrowski J, Caron MG, Lefkowitz RJ (1992): Constitutive activation of the alpha IB-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. J Biol Chem 267:1430-1433.
    • (1992) J Biol Chem , vol.267 , pp. 1430-1433
    • Kjelsberg, M.A.1    Cotecchia, S.2    Ostrowski, J.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 45
    • 0029126526 scopus 로고
    • Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: Interactions of strychnine and acetylcholine at muscarinic receptors
    • Lazareno S, Birdsall NJ (1995): Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: Interactions of strychnine and acetylcholine at muscarinic receptors. Mol Pharmacol 48:362-378.
    • (1995) Mol Pharmacol , vol.48 , pp. 362-378
    • Lazareno, S.1    Birdsall, N.J.2
  • 47
    • 0025875643 scopus 로고
    • Allosteric antagonists of the muscarinic acetylcholine receptor
    • Lee NH, El-Fakahany EE (1991a): Allosteric antagonists of the muscarinic acetylcholine receptor. Biochem Pharmacol 42:199-205.
    • (1991) Biochem Pharmacol , vol.42 , pp. 199-205
    • Lee, N.H.1    El-Fakahany, E.E.2
  • 48
    • 0026084739 scopus 로고
    • Allosteric interactions at the m1, m2 and m3 muscarinic receptor subtypes
    • Lee NH, El-Fakahany EE (1991b): Allosteric interactions at the m1, m2 and m3 muscarinic receptor subtypes. J Pharmacol Exp Ther 256:468-479.
    • (1991) J Pharmacol Exp Ther , vol.256 , pp. 468-479
    • Lee, N.H.1    El-Fakahany, E.E.2
  • 49
    • 0026689405 scopus 로고
    • Modulation by certain conserved aspartate residues of the allosteric interaction of gallamine at the m1 muscarinic receptor
    • Lee NH, Hu J, El-Fakahany EE (1992): Modulation by certain conserved aspartate residues of the allosteric interaction of gallamine at the m1 muscarinic receptor. J Pharmacol Exp Ther 262:312-316.
    • (1992) J Pharmacol Exp Ther , vol.262 , pp. 312-316
    • Lee, N.H.1    Hu, J.2    El-Fakahany, E.E.3
  • 50
    • 0028950255 scopus 로고
    • The two-state model of receptor activation
    • Leff P (1995): The two-state model of receptor activation. Trends Pharmacol Sci 16:89-97.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 89-97
    • Leff, P.1
  • 51
    • 0028241381 scopus 로고
    • Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor
    • Leppik RA, Miller RC, Eck M, Paquet JL (1994): Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor. Mol Pharmacol 45:983-990.
    • (1994) Mol Pharmacol , vol.45 , pp. 983-990
    • Leppik, R.A.1    Miller, R.C.2    Eck, M.3    Paquet, J.L.4
  • 52
    • 0028815463 scopus 로고
    • Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis
    • Matsui H, Lazareno S, Birdsall NJ (1995): Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis. Mol Pharmacol 47:88-98.
    • (1995) Mol Pharmacol , vol.47 , pp. 88-98
    • Matsui, H.1    Lazareno, S.2    Birdsall, N.J.3
  • 53
    • 0027485462 scopus 로고
    • Purification and properties of mitoxin, a specific antagonist of m1 muscarinic receptors
    • Max SI, Liang JS, Potter LT (1993a): Purification and properties of mitoxin, a specific antagonist of m1 muscarinic receptors. J Neurosci 13:4293-4300.
    • (1993) J Neurosci , vol.13 , pp. 4293-4300
    • Max, S.I.1    Liang, J.S.2    Potter, L.T.3
  • 54
    • 0027787642 scopus 로고
    • Stable allosteric binding of m1-toxin to m1 muscarinic receptors
    • Max SI, Liang JS, Potter LT (1993b): Stable allosteric binding of m1-toxin to m1 muscarinic receptors. Mol Pharmacol 44:1171-1175.
    • (1993) Mol Pharmacol , vol.44 , pp. 1171-1175
    • Max, S.I.1    Liang, J.S.2    Potter, L.T.3
  • 55
    • 0029134791 scopus 로고
    • Positive allosteric action of alcuronium on solubilized cardiac muscarinic receptors
    • Musilkova J, Tucek S (1995): Positive allosteric action of alcuronium on solubilized cardiac muscarinic receptors. Neurochem Int 27:337-343.
    • (1995) Neurochem Int , vol.27 , pp. 337-343
    • Musilkova, J.1    Tucek, S.2
  • 56
    • 0024394329 scopus 로고
    • Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate
    • Poyner DR, Birdsall NJ, Curtis C, Eveleigh P, Hulme EC, Pedder EK, Wheatley M (1989): Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate. Mol Pharmacol 36:420-429.
    • (1989) Mol Pharmacol , vol.36 , pp. 420-429
    • Poyner, D.R.1    Birdsall, N.J.2    Curtis, C.3    Eveleigh, P.4    Hulme, E.C.5    Pedder, E.K.6    Wheatley, M.7
  • 57
    • 0028231689 scopus 로고
    • Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors
    • Proska J, Tucek S (1994): Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors. Mol Pharmacol 45:709-717.
    • (1994) Mol Pharmacol , vol.45 , pp. 709-717
    • Proska, J.1    Tucek, S.2
  • 58
    • 0028840330 scopus 로고
    • Competition between positive and negative allosteric effectors on muscarinic receptors
    • Proska J, Tucek S (1995): Competition between positive and negative allosteric effectors on muscarinic receptors. Mol Pharmacol 48:696-702.
    • (1995) Mol Pharmacol , vol.48 , pp. 696-702
    • Proska, J.1    Tucek, S.2
  • 59
    • 0038342828 scopus 로고    scopus 로고
    • Positive allosteric action of eburnamonine on cardiac muscarinic acetylcholine receptors
    • Proska J, Tucek S (1996): Positive allosteric action of eburnamonine on cardiac muscarinic acetylcholine receptors. Eur J Pharmacol 305:201-205.
    • (1996) Eur J Pharmacol , vol.305 , pp. 201-205
    • Proska, J.1    Tucek, S.2
  • 60
    • 0027296623 scopus 로고
    • Constitutively active mutants of the alpha 2-adrenergic receptor
    • Ren Q, Kurose H, Lefkowitz RJ, Cotecchia S (1993): Constitutively active mutants of the alpha 2-adrenergic receptor. J Biol Chem 268:16483-16487.
    • (1993) J Biol Chem , vol.268 , pp. 16483-16487
    • Ren, Q.1    Kurose, H.2    Lefkowitz, R.J.3    Cotecchia, S.4
  • 61
    • 0027513982 scopus 로고
    • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model
    • Samama P, Cotecchia S, Costa T, Lefkowitz RJ (1993): A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem 268:4625-4636.
    • (1993) J Biol Chem , vol.268 , pp. 4625-4636
    • Samama, P.1    Cotecchia, S.2    Costa, T.3    Lefkowitz, R.J.4
  • 62
    • 0021246750 scopus 로고
    • Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells
    • Soejima M, Noma A (1984): Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells. Pflugers Arch - Eur J Physiol 400:424-431.
    • (1984) Pflugers Arch - Eur J Physiol , vol.400 , pp. 424-431
    • Soejima, M.1    Noma, A.2
  • 63
    • 0028087860 scopus 로고
    • Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors
    • Spalding TA, Birdsall NJ, Curtis CA, Hulme EC (1994): Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors. J Biol Chem 269:4092-4097.
    • (1994) J Biol Chem , vol.269 , pp. 4092-4097
    • Spalding, T.A.1    Birdsall, N.J.2    Curtis, C.A.3    Hulme, E.C.4
  • 65
    • 0020533362 scopus 로고
    • Modification of the binding properties of muscarinic receptors by gallamine
    • Stockton JM, Birdsall NJ, Burgen AS, Hulme EC (1983): Modification of the binding properties of muscarinic receptors by gallamine. Mol Pharmacol 23:551-557.
    • (1983) Mol Pharmacol , vol.23 , pp. 551-557
    • Stockton, J.M.1    Birdsall, N.J.2    Burgen, A.S.3    Hulme, E.C.4
  • 66
    • 0023769440 scopus 로고
    • Apparent competitive inhibition of radioligand binding to receptors: Experimental and theoretical considerations in the analysis of equilibrium binding data
    • Tomlinson G, Hnatowich MR (1988): Apparent competitive inhibition of radioligand binding to receptors: Experimental and theoretical considerations in the analysis of equilibrium binding data. J Receptor Res 8:809-830.
    • (1988) J Receptor Res , vol.8 , pp. 809-830
    • Tomlinson, G.1    Hnatowich, M.R.2
  • 67
    • 0029055030 scopus 로고
    • Allosteric modulation of muscarinic acetylcholine receptors
    • Tucek S, Proska J (1995): Allosteric modulation of muscarinic acetylcholine receptors. Trends Pharmacol Sci 16:205-212.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 205-212
    • Tucek, S.1    Proska, J.2
  • 68
    • 0025203309 scopus 로고
    • Positive cooperativity in the binding of alcnronium and N-methylscopolamine to muscarinic acetylcholine receptors
    • Tucek S, Musilkova J, Nedoma J, Proska J, Shelkovnikov S, Vorlicek J (1990): Positive cooperativity in the binding of alcnronium and N-methylscopolamine to muscarinic acetylcholine receptors. Mol Pharmacol 38:674-680.
    • (1990) Mol Pharmacol , vol.38 , pp. 674-680
    • Tucek, S.1    Musilkova, J.2    Nedoma, J.3    Proska, J.4    Shelkovnikov, S.5    Vorlicek, J.6
  • 69
    • 0023802955 scopus 로고
    • Effects of d-tubocurarine on rat cardiac muscarinic receptors: A comparison with gallamine
    • Waelbroeck M, Robberecht P, De Neef P, Christophe J (1988): Effects of d-tubocurarine on rat cardiac muscarinic receptors: A comparison with gallamine. J Receptor Res 8:787-808.
    • (1988) J Receptor Res , vol.8 , pp. 787-808
    • Waelbroeck, M.1    Robberecht, P.2    De Neef, P.3    Christophe, J.4
  • 70
    • 0028062082 scopus 로고
    • Identification of drugs competing with d-tubocurarine for an allosteric site on cardiac muscarinic receptors
    • Waelbroeck M (1994): Identification of drugs competing with d-tubocurarine for an allosteric site on cardiac muscarinic receptors. Mol Pharmacol 46:685-692.
    • (1994) Mol Pharmacol , vol.46 , pp. 685-692
    • Waelbroeck, M.1
  • 72
    • 0026517079 scopus 로고
    • Structural basis of the subtype selectivity of muscarinic antagonists: A study with chimeric m2/m5 muscarinic receptors
    • Wess J, Gdula D, Brann MR (1992): Structural basis of the subtype selectivity of muscarinic antagonists: A study with chimeric m2/m5 muscarinic receptors. Mol Pharmacol 41:369-374.
    • (1992) Mol Pharmacol , vol.41 , pp. 369-374
    • Wess, J.1    Gdula, D.2    Brann, M.R.3
  • 73
    • 0023830595 scopus 로고
    • i-protein in membranes of human platelets
    • i-protein in membranes of human platelets. Biochem J 249:857-863.
    • (1988) Biochem J , vol.249 , pp. 857-863
    • Willuweit, B.1    Aktories, K.2
  • 74
    • 0029083945 scopus 로고
    • Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors
    • Wreggett KA, Wells JW (1995): Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors. J Biol Chem 270:22488-22499.
    • (1995) J Biol Chem , vol.270 , pp. 22488-22499
    • Wreggett, K.A.1    Wells, J.W.2


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