Activation of small GTPase Ras and renal fibrosis

Journal of Nephrology

Volumn 18, Issue 3, 2005, Pages 341-349

  Rodríguez Peña, Ana B ^a   Santos, Eugenio ^a   Arévalo, Miguel ^a   López Novoa, José M ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Mesangial cells; Renal fibroblasts; Renal fibrosis; Small GTPases; Tubular epithelial cells

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CYTOKINE; GLUCOSE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN;

APOPTOSIS; CELL DIFFERENTIATION; CELL GROWTH; CELL MEMBRANE; CELL PROLIFERATION; CONFERENCE PAPER; FIBROBLAST; HUMAN; KIDNEY FIBROSIS; KIDNEY INJURY; MESANGIUM CELL; ONCOGENE H RAS; ONCOGENE N RAS; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; ENZYME ACTIVATION; FIBROBLASTS; FIBROSIS; HUMANS; KIDNEY; RAS GTPASE-ACTIVATING PROTEINS; SIGNAL TRANSDUCTION;

EID: 23144455793     PISSN: 11218428     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (72)

1. Frohlich ED. Hypertension: our major challenges. Hypertension 2001; 38: 990-1.
2. Takai Y, Sasaki T and Matozaki T. Small GTP-binding proteins. Physiol Rev 2001; 81: 153-208.
3. Rojas JM, Santos E. Ras genes and human cancer: Different implications and different roles. Curr Genomics 2002; 3: 295-311.
4. Eguchi S, Inagami T. Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase. Regul Pept 2000; 91: 13-20.
5. Yin G, Yan C, Berk BC. Angiotensin II signaling pathways mediated by tyrosine kinases. Int J Biochem Cell Biol 2003; 35: 780-3.
6. Touyz RM, Schiffrin EL. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 2000; 52: 639-72.
7. Humphries MJ, Travis MA, Clark K, Mould AP. Mechanisms of integration of cells and extracellular matrices by integrins. Biochem Soc Trans 2004; 32: 822-5.
8. Lee JW, Juliano R. Mitogenic signal transduction by integrin-and growth factor receptor-mediated pathways. Mol Cells 2004; 17: 188-202.
9. Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999; 285: 1028-32.
10. Liu S, Calderwood DA, Ginsberg MH. Integrin cytoplasmic domain-binding proteins. J Cell Sci 2000; 113: 3563-71.
11. Calderwood DA. Integrin activation. J Cell Sci 2004; 117: 657-66.
12. Hancock JF. Ras proteins: Different signals from different locations. Nat Rev Mol Cell Biol 2003; 4: 373-84.
13. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103: 211-25.
14. Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T, Otani H, Aiba A, Katsuki M. K-ras is essential for the development of the mouse embryo. Oncogene 1997; 15: 1151-9.
15. Esteban LM, Vicario-Abejon C, Fernandez-Salguero P, Fernandez-Medarde A, Swaminathan N, Yienger K, Lopez E, Malumbres M, McKay R, Ward JM, Pellicer A, Santos E. Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development. Mol Cell Biol 2001; 21: 1444-52.
16. Avruch J, Khokhlatchev A, Kyriakis JM, Luo Z, Tzivion G, Vavvas D, Zhang XF. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res 2001; 56: 127-55.
17. Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 2001; 70: 535-602.
18. Katz ME, McCormick F. Signal transduction from multiple Ras effectors. Curr Opin Genet Dev 1997; 7: 75-9.
19. Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T. Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. J Biol Chem 2001; 276: 2752-7.
20. Dhillon AS, Kolch W. Untying the regulation of the Raf-1 kinase. Arch Biochem Biophys 2002; 404: 3-9.
21. Dhillon AS, Pollock C, Steen H, Shaw PE, Mischak H, Kolch W. Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259. Mol Cell Biol 2002; 22: 3237-46.
22. Dumaz N, Marais R. Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J Biol Chem 2003; 278: 29819-23.
23. Jun T, Gjoerup O, Roberts TM. Tangled webs: Evidence of cross-talk between c-Raf-1 and Akt. Sci STKE 1999; 1999: PE1.
24. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH. MAP kinases. Chem Rev 2001b; 101: 2449-76.
25. Biondi RM, Nebreda AR. Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem J 2003; 372: 1-13.
26. Sharrocks AD. The ETS-domain transcription factor family. Nat Rev Mol Cell Biol 2001; 2: 827-37.
27. Gijon MA, Leslie CC. Regulation of arachidonic acid release and cytosolic phospholipase A2 activation. J Leukoc Biol 1999; 65: 330-6.
28. Vanhaesebroeck B, Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 2000; 346: 561-76.
29. Brazil DP, Hemmings BA. Ten years of protein kinase B signalling: A hard Akt to follow. Trends Biochem Sci 2001; 26: 657-64.
30. Barbacid M. Ras genes. Annu Rev Biochem 1987; 56: 779-827.
31. Kocher HM, Moorhead J, Sharpe CC, Dockrell ME, Al-Nawab M, Hendry BM. Expression of Ras GTPases in normal kidney and in glomerulonephritis. Nephrol Dial Transplant 2003; 18: 2284-92.
32. Schlondorff D. The glomerular mesangial cell: An expanding role for a specialized pericyte. FASEB J 1987; 1: 272-81.
33. Zhang G, Moorhead PJ, el Nahas AM. Myofibroblasts and the progression of experimental glomerulonephritis. Exp Nephrol 1995; 3: 308-18.
34. Howe AK, Juliano RL. Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/mitogen-activated protein kinase cascade. J Biol Chem 1998; 273: 27268-74.
35. Buday L, Downward J. Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts. Mol Cell Biol 1993; 13: 1903-10.
36. Sharpe CC, Dockrell ME, Scott R, Noor MI, Cowsert LM, Monia BP, Hendry BM. Evidence of a role for Ki-Ras in the stimulated proliferation of renal fibroblasts. J Am Soc Nephrol 1999; 10: 1186-92.
37. Sharpe CC, Dockrell ME, Noor MI, Monia BP, Hendry BM. Role of Ras isoforms in the stimulated proliferation of human renal fibroblasts in primary culture. J Am Soc Nephrol 2000; 11: 1600-6.
38. Wolf G, Ziyadeh FN. Molecular mechanisms of diabetic renal hypertrophy. Kidney Int 1999; 56: 393-405.
39. Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994; 331: 1286-92.
40. Bassa BV, Roh DD, Vaziri ND, Kirschenbaum MA, Kamanna VS. Lysophosphatidylcholine activates mesangial cell PKC and MAP kinase by PLCgamma-1 and tyrosine kinase-Ras pathways. Am J Physiol 1999; 277: F328-37.
41. Herman WH, Simonson MS. Nuclear signaling by endothelin-1. A Ras pathway for activation of the c-fos serum response element. J Biol Chem 1995; 270: 11654-61.
42. Foschi M, Chari S, Dunn MJ, Sorokin A. Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase. EMBO J 1997; 16: 6439-51.
43. Ma H, Matsunaga H, Li B, Schieffer B, Marrero MB, Ling BN. Ca2+ channel activation by platelet-derived growth factor-induced tyrosine phosphorylation and Ras guanine triphosphate-binding proteins in rat glomerular mesangial cells. J Clin Invest 1996; 97: 2332-41.
44. Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy. Proc Natl Acad Sci USA 2002; 99: 8301-5.
45. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: A review. Diabetologia 2001; 44: 129-46.
46. Chen S, Cohen MP, Lautenslager GT, Shearman CW, Ziyadeh FN. Glycated albumin stimulates TGF-beta 1 production and protein kinase C activity in glomerular endothelial cells. Kidney Int 2001a; 59: 673-81.
47. Yamamoto Y, Kato I, Doi T, Yonekura H, Ohashi S, Takeuchi M, Watanabe T, Yamagishi S, Sakurai S, Takasawa S, Okamoto H, Yamamoto H. Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J Clin Invest 2001; 108: 261-8.
48. Xu D, Kyriakis JM. Phosphatidylinositol 3′-kinase-dependent activation of renal mesangial cell Ki-Ras and ERK by advanced glycation end products. J Biol Chem 2003; 278: 39349-55.
49. Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001; 17: 615-75.
50. Rodriguez-Peña A, Docherthy N, Guerrero C, Grande M, Santos E, Eleno N, López-Novoa J. Contribution of Ras GT-PAse/MAP kinase to renal fibrosis induced by unilateral ureteral obstruction. Hypertension 2003; 42: 441 P192.
51. Guo DF, Sun YL, Hamet P, Inagami T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell Res 2001; 11: 165-80.
52. Santibanez JF, Guerrero J, Quintanilla M, Fabra A, Martinez J. Transforming growth factor-beta1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes. Biochem Biophys Res Commun 2002; 296: 267-73.
53. Che W, Abe J, Yoshizumi M, Huang Q, Glassman M, Ohta S, Melaragno MG, Poppa V, Yan C, Lerner-Marmarosh N, Zhang C, Wu Y, Arlinghaus R, Berk BC. p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells. Circulation 2001; 104: 1399-406.
54. Robin P, Boulven I, Bole-Feysot C, Tanfin Z, Leiber D. Contribution of PKC-dependent and -independent processes in temporal ERK regulation by ET-1, PDGF, and EGF in rat myometrial cells. Am J Physiol Cell Physiol 2004; 286: C798-806.
55. Wang L, Proud CG. Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes. Circ Res 2002; 91: 821-9.
56. Lin CC, Shyr MH, Chien CS, Wang CC, Chiu CT, Hsiao LD, Yang CM. Thrombin-stimulated cell proliferation mediated through activation of Ras/Raf/MEK/MAPK pathway in canine cultured tracheal smooth muscle cells. Cell Signal 2002; 14: 265-75.
57. Graciano ML, Cavaglieri Rde C, Delle H, Dominguez WV, Casarini DE, Malheiros DM, Noronha IL. Intrarenal Renin-Angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis. J Am Soc Nephrol 2004; 15: 1805-15.
58. Kaneto H, Morrissey J, McCracken R, Reyes A, Klahr S. Enalapril reduces collagen type IV synthesis and expansion of the interstitium in the obstructed rat kidney. Kidney Int 1994; 45: 1637-47.
59. Isaka Y, Tsujie M, Ando Y, Nakamura H, Kaneda Y, Imai E, Hori M. Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction. Kidney Int 2000; 58: 1885-92.
60. Francois H, Placier S, Flamant M, Tharaux PL, Chansel D, Dussaule JC, Chatziantoniou C. Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition. FASEB J 2004; 18: 926-8.
61. Chade AR, Best PJ, Rodriguez-Porcel M, Herrmann J, Zhu X, Sawamura T, Napoli C, Lerman A, Lerman LO. Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia. Kidney Int 2003; 64: 962-9.
62. Rodriguez-Pena A, Eleno N, Duwell A, Arevalo M, Perez-Barriocanal F, Flores O, Docherty N, Bernabeu C, Letarte M, Lopez-Novoa JM. Endoglin upregulation during experimental renal interstitial fibrosis in mice. Hypertension 2002; 40: 713-20.
63. Purcell WT, Donehower RC. Evolving therapies: Farnesyl-transferase inhibitors. Curr Oncol Rep 2002; 4: 29-36.
64. Sebti S, Hamilton AD. Inhibitors of prenyl transferases. Curr Opin Oncol 1997; 9: 557-61.
65. Guijarro C, Kim Y, Schoonover CM, Massy ZA, O'Donnell MP, Kasiske, BL, Keane WF, Kashtan, CE. Lovastatin inhibits lipopolysaccharide-induced NF-kappaB activation in human mesangial cells. Nephrol Dial Transplant 1996; 11: 990-6.
66. Miller AC, Samid D. Tumour resistance to oxidative stress: Association with ras oncogene expression and reversal by lovastatin, an inhibitor of p21-ras isoprenylation. Int J Cancer 1995; 60: 249-54.
67. Sebti SM, Tkalcevic GT, Jani JP. Lovastatin a cholesterol biosynthesis inhibitor, inhibits growth of human H-ras oncogene transformed cells in nude mice. Cancer Commun 1991; 60: 141-7.
68. O'Donnell MP, Kasiske BL, Kim Y, Atluru D, Keane WF. Lovastatin inhibits proliferation of rat mesangial cells. J Clin Invest 1993; 91: 83-7.
69. Massy ZA, Guijarro C, Oda H, Kasiske BL, Keane WF, O'Donnell MP. Importance of geranylgeranyl pyrophosphate for mesangial cell DNA synthesis. Kidney Int 1999; 71 (suppl): S80-3.
70. Nabeshima K, Inui K, Uda S, Sugenoya Y, Iwasaki S, Ideura T, Yoshimura A. HMG CoA reductase inhibitor suppression of glomerular cell proliferation in rats with a9ti-Thy-1.1 nephritis. Contrib Nephrol 1997; 120: 153-9.
71. Soma MR, Donetti E, Parolini C, Mazzini G, Ferrari C, Fumagalli R, Paoletti R. HMG CoA reductase inhibitors. In vivo effects on carotid intimal thickening in normocholesterolemic rabbits. Arterioscler Thromb 1993; 13: 571-8.
72. Stacey, DW. The ras pathway: A model for the control of proliferation in animal cells. Adv Exp Med Biol 1988; 234: 141-67.