Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes

Biochemical and Biophysical Research Communications

Volumn 296, Issue 2, 2002, Pages 267-273

  Santibanez, Juan Francisco ^a   Guerrero, Javier ^a   Quintanilla, Miguel ^b   Fabra, Angels ^c   Martínez, Jorge ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c Institut de Recerca Oncologica   (Spain)

Author keywords

Keratinocytes; Migration; MMP 9; Ras ERK; TGF 1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTISENSE OLIGODEOXYNUCLEOTIDE; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; RAS PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CANCER INVASION; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVITY; GENE MUTATION; GENETIC TRANSFECTION; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0036386902     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00864-1     Document Type: Article

References (31)

1. E.C. Woodhouse, R.F. Chuaqui, L.A. Liotta, General mechanisms of metastasis, Cancer 80 (1997) 1529-1537.
2. I. Massova, L. Kotra, R. Fridman, S. Mobashery, Matrix metalloproteinases: structures, evolution, and diversification, FASEB J. 12 (1998) 1075-1095.
3. E. Bernhard, S. Gruber, R. Muschel, Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells, Proc. Natl. Acad. Sci. USA 91 (1994) 4293-4297.
4. J. Westermarck, V. Kahari, Regulation of matrix metalloproteinase expression in tumor invasion, FASEB J. 13 (1999) 781-792.
5. S.K. Chintala, R. Sawaya, B.B. Aggarwal, S. Majumder, D.K. Giri, A.P. Kyritsis, Z.L. Gokaslan, J.S. Rao, Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells, J. Biol. Chem. 273 (1998) 13545-13551.
6. B. Xie, A. Laouar, E. Huberman, Fibronectin-mediated cell adhesion is required for induction of 92-kDa type IV collagenase/gelatinase (MMP-9) gene expression during macrophage differentiation. The signaling role of protein kinase C-β, J. Biol. Chem. 273 (1998) 11576-11582.
7. J.G. Lyons, B. Birkedal-Hansen, M.C. Pierson, J.M. Whitelock, H. Birkedal-Hansen, Interleukin-1β and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes, J. Biol. Chem. 268 (1993) 19143-19151.
8. H. Sato, M. Seiki, Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells, Oncogene 8 (1993) 395-405.
9. K. Shibata, F. Kikkawa, A. Nawa, A.A. Thant, K. Naruse, S. Mizutani, M. Hamaguchi, Both focal adhesion kinase and c-Ras are required for the enhanced matriz metalloproteinase 9 secretion by fibronectin in ovarian cancer cells, Cancer Res. 58 (1998) 900-903.
10. R. Gum, E. Lengyel, J. Juarez, J.H. Chen, H. Sato, D. Boyd, Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences, J. Biol. Chem. 271 (1996) 10672-10680.
11. C. Caulin, F. Scholl, P. Frontelo, C. Gamallo, M. Quintanilla, Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-β1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype, Cell Growth Differ. 6 (1995) 1027-1035.
12. P. Frontelo, M. González-Garrigues, S. Vilaró, C. Gamallo, A. Fabra, M. Quintanilla, Transforming growth factor β1 induces squamous carcinoma cell variants with increased metastatic abilities and a disorganized cytoskeleton, Exp. Cell Res. 244 (1998) 420-432.
13. J.F. Santibáñez, P. Frontelo, M. Iglesias, J. Martínez, M. Quintanilla, Urokinase expression and binding activity associated with the transforming growth factor β1-induced migratory and invasive phenotype of mouse epidermal keratinocytes
14. J.F. Santibáñez, M. Iglesias, P. Frontelo, J. Martínez, M. Quintanilla, Involvement of the Ras/MAPK signaling in the modulation of urokinase production and cellular invasiveness by transforming geowth factor-β1 in transformed keratinocytes, Biochem. Biophys. Res. Commun. 273 (2000) 521-527.
15. R. Arkhurst, A. Balmain, Genetic events and the role of TGF-β in epithelial tumour progression, J. Pathol. 187 (1999) 82-90.
16. J. Massagué, TGF-β signal transduction, Annu. Rev. Biochem. 67 (1998) 753-791.
17. M. Hartsough, K. Mulder, Transforming growth factor-β signaling in epithelial cells, Pharmacol. Ther. 75 (1997) 21-41.
18. I. Sehgal, T.C. Thompson, Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-β1 in human prostate cancer cell lines, Mol. Biol. Cell 10 (1999) 407-416.
19. U.K. Laemmli, Clevage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227 (1970) 680-685.
20. M. Diaz-Guerra, S. Haddow, C. Bauluz, J. Jorcano, A. Cano, A. Balmain, M. Quintanilla, Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey-ras gene alterations, Cancer Res. 52 (1992) 680-687.
21. M. Iglesias, P. Frontelo, C. Gamallo, M. Quintanilla, Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas, Oncogene 19 (2000) 4134-4414.
22. D. Grobelny, L. Poncz, R.E. Galardy, Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids, Biochemistry 31 (1992) 7152-7154.
23. L.J. McCawley, P. Obrien, L.G. Hudson, Epidermal growth factor (EGF)- and scatter factor/hepatocyte growth factor (SF/HGF)-mediated keratinocyte migration is coincident with induction of matrix metalloproteinase (MMP)-9, J. Cell. Physiol. 176 (1998) 255-265.
24. L.J. McCawley, S. Li, E. Wattenberg, L.G. Hudson, Sustained activation of the mitogen-activated protein kinase pathway. A mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration, J. Biol. Chem. 274 (1999) 4347-4353.
25. U. Thorgeisson, T. Turpeenniemi-Hujajen, J. Willians, E. Westin, C. Heilman, J. Talmadge, L. Liotta, NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice, Mol. Cell. Biol. 5 (1985) 259-262.
26. C. Simon, J. Juarez, G.L. Nicolson, D. Boyd, Effect of PD098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion, Cancer Res. 56 (1996) 5369-5374.
27. R. Gum, H. Wang, E. Lengyel, K. Juarez, D. Boyd, Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades, Oncogene 14 (1997) 1481-1493.
28. C. Simon, H. Goefert, D. Boyd, Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion, Cancer Res. 58 (1998) 1135-1139.
29. D. Welch, T. Sakamaky, R. Pioquinto, T. Leonard, S. Goldberg, Q. Hon, R. Erickson, M. Rieber, M. Rieber, D. Hicks, J. Bonventre, A. Alessandrini, Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells, Cancer Res. 60 (2000) 1552-1556.
30. A. Buchmann, B. Ruggeri, A.J.P. Klein-Szanto, A. Balmain, Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7, Cancer Res. 51 (1991) 4097-4101.
31. S. Linardopoulos, A.J. Street, D.E. Quelle, D. Parry, G. Peters, C.J. Sherr, A. Balmain, Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors, Cancer Res. 55 (1995) 5168-5172.