Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation

Development

Volumn 132, Issue 6, 2005, Pages 1363-1374

  Okubo, Tadashi ^a   Knoepfler, Paul S ^b   Eisenman, Robert N ^b   Hogan, Brigid L M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Conditional inactivation; Differentation; Growth; Lung development; Nmyc; Progenitor cells; Sox proteins

Indexed keywords

ONCOPROTEIN; SURFACTANT PROTEIN C; TRANSCRIPTION FACTOR SOX9;

ANIMAL CELL; ANIMAL EMBRYO; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; ELECTRON MICROSCOPY; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; EPITHELIUM CELL; GENE DELETION; GENE FUNCTION; GENE OVEREXPRESSION; LUNG ALVEOLUS CELL; LUNG CANCER; LUNG DEVELOPMENT; LUNG DYSPLASIA; MOUSE; MOUSE STRAIN; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; GENES, REPORTER; HIGH MOBILITY GROUP PROTEINS; LUNG; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; PROTO-ONCOGENE PROTEINS C-MYC; RECOMBINANT FUSION PROTEINS; S PHASE; STEM CELLS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 17244375059     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01678     Document Type: Article

References (44)

1. Arnold, I. and Watt, F. M. (2001). c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr. Biol. 11, 558-568.
2. Blache, P., van de Wetering, M., Dulue, I., Domon, C., Berta, P., Freund, J. N., Clevers, H. and Jay, P. (2004). SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J. Cell Biol. 166, 37-47.
3. Boon, K., Caron, H. N., van Asperen, R., Valentijn, L., Hermus, M. C., van Sluis, P., Roobeek, I., Weis, I., Voute, P. A., Schwab, M. et al. (2001). N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis. EMBO J. 20, 1383-1393.
4. Cardoso, W. V. (2000). Lung morphogenesis revisited: old facts, current ideas. Dev. Dyn. 219, 121-130.
5. de la Cova, C., Abril, M., Bellosta, P., Gallant, P. and Johnston, L. A. (2004). Drosophila myc regulates organ size by inducing cell competition. Cell 117, 107-116.
6. Eisenman, R. N. (2001). Deconstructing myc. Genes Dev. 15, 2023-2030.
7. Frederick, J. P., Liberati, N. T., Waddell, D. S., Shi, Y. and Wang, X. F. (2004). Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol. Cell. Biol. 24, 2546-2559.
8. Frye, M., Gardner, C., Li, E. R., Arnold, I. and Watt, F. M. (2003). Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development 130, 2793-2808.
9. Gasca, S., Canizares, J., De Santa Barbara, P., Mejean, C., Poulat, F., Berta, P. and Bolzet-Bonhoure, B. (2002). A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination. Proc. Natl. Acad. Sci. USA 99, 11199-11204.
10. Gebb, S. A. and Shannon, J. M. (2000). Tissue interactions mediate early events in pulmonary vasculogenesis. Dev. Dyn. 217, 159-169.
11. Hipfner, D. R. and Cohen, S. M. (2004). Connecting proliferation and apoptosis in development and disease. Nat. Rev. Mol. Cell. Biol. 5, 805-815.
12. Hueber, A. O. and Evan, G. I. (1998). Traps to catch unwary oncogenes. Trends Genet. 14, 364-367.
13. Kenney, A. M., Cole, M. D. and Rowitch, D. H. (2003). Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development 130 15-28.
14. Kenney, A. M., Widlund, H. R. and Rowitch, D. H. (2004). Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 131, 217-228.
15. Knoepfler, P. S., Cheng, P. F. and Eisenman, R. N. (2002). N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 16, 2699-2712.
16. Levens, D. L. (2003). Reconstructing MYC. Genes Dev. 17, 1071-1077.
17. Linder, B., Gerlach, N. and Jackle, H. (2001). The Drosophila homolog of the human AF10 is an HP1-interacting suppressor of position effect variegation. EMBO Rep. 2, 211-216.
18. Miaw, S. C., Choi, A., Yu, E., Kishikawa, H. and Ho, I. C. (2000). ROG, repressor of GATA, regulates the expression of cytokine genes. Immunity 12, 323-333.
19. Moens, C. B., Auerbach, A. B., Conlon, R. A., Joyner, A. L. and Rossant, J. (1992). A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. Genes Dev. 6, 691-704.
20. Moens, C. B., Stanton, B. R., Parada, L. F. and Rossant, J. (1993). Defects in heart and lung development in compound heterzygotes for two different targeted mutations at the N-myc locus. Development 119, 485-499.
21. Moniot, B., Biau, S., Faure, S., Nielsen, C. M., Berta, P., Roberts, D. J. and de Santa Barbara, P. (2004). SOX9 specifies the pyloric sphincter epithelium through mesenchymal-epithelial signals. Development 131, 3795-3804.
22. Moreno, E. and Basler, K. (2004). dMyc transforms cells into super-competitors. Cell 117, 117-129.
23. Newton, K., Petfalski, E., Tollervey, D. and Caceres, J. F. (2003). Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse. Mol. Cell. Biol. 23, 8519-8527.
24. Okubo, T. and Hogan, B. L. (2004). Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. J. Biol. 3, 11.
25. Patel, J. H., Loboda, A. P., Showe, M. K., Showe, L. C. and McMahon, S. B. (2004). Opinion: analysis of genomic targets reveals complex functions of MYC. Nat. Rev. Cancer 4, 562-568.
26. Penn, L. J., Brooks, M. W., Laufer, E. M. and Land, H. (1990). Negative autoregulation of c-myc transcription. EMBO J. 9, 1113-1121.
27. Perl, A. K., Wert, S. E., Nagy, A., Lobe, C. G. and Whitsett, J. A. (2002). Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc. Natl. Acad. Sci. USA 99, 10482-10487.
28. Raetz, E. A., Kim, M. K., Moos, P., Carlson, M., Bruggers, C., Hooper, D. K., Foot, L., Liu, T., Seeger, R. and Carroll, W. L. (2003). Identification of genes that are regulated transcriptionally by Myc in childhood tumors. Cancer 98, 841-853.
29. Rosenblatt, J., Raff, M. C. and Cramer, L. P. (2001). An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Curr. Biol. 11, 1847-1857.
30. Sawai, S., Shimono, A., Wakamatsu, Y., Palmes, C., Hanaoka, K. and Kondoh, H. (1993). Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse. Development 117, 1445-1455.
31. Shiio, Y., Donohoe, S., Yi, E. C., Goodlett, D. R., Aebersold, R. and Eisenman, R. N. (2002). Quantitative proteomic analysis of Myc oncoprotein function. EMBO J. 21, 5088-5096.
32. Stanton, B. R., Perkins, A. S., Tessarollo, L., Sassoon, D. A. and Parada, L. F. (1992). Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev. 6, 2235-2247.
33. Ten Have-Opbroek, A. A. W. (1981). The development of the lung in mammals: an analysis of concepts and findings. Am. J. Anat. 162, 201-219.
34. Ten Have-Opbroek, A. A. W. (1991). Lung development in the mouse embryo. Exp. Lung Res. 17, 111-130.
35. Tsai, R. Y. and McKay, R. D. (2002). A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Genes Dev. 16, 2991-3003.
36. Wakamatsu, Y., Watanabe, Y., Shimono, A. and Kondoh, H. (1993). Transition of localization of the N-Myc protein from nucleus to cytoplasm in differentiating neurons. Neuron 10, 1-9.
37. Warburton, D., Schwarz, M., Tefft, D., Flores-Delgado, G., Anderson, K. D. and Cardoso, W. V. (2000). The molecular basis of lung morphogenesis. Mech. Dev. 92, 55-81.
38. Wartiovaara, K., Barnabe-Heider, F., Miller, F. D. and Kaplan, D. R. (2002). N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J. Neurosci. 22, 815-824.
39. Weaver, M., Yingling, J. M., Dunn, N. R., Bellusci, S. and Hogan, B. L. (1999). Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. Development 126, 4005-4015.
40. Weaver, M., Batts, L. and Hogan, B. L. (2003). Tissue interactions pattern the mesenchyme of the embryonic mouse lung. Dev. Biol. 258, 169-184.
41. Wert, S. E., Glasser, S. W., Korfhagen, T. R. and Whitsett, J. A. (1993). Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice. Dev. Biol. 156, 426-443.
42. Westbury, J., Watkins, M., Ferguson-Smith, A. C. and Smith, J. (2001). Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis. Mech. Dev. 109 83-89.
43. Yang, H., Lu, M. M., Zhang, L., Whitsett, J. A. and Morrisey, E. E. (2002). GATA6 regulates differentiation of distal lung epithelium. Development 129, 2233-2246.
44. Zeller, K. I., Jegga, A. G., Aronow, B. J., O'Donnell, K. A. and Dang, C. V. (2003). An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol. 4, R69.