Species differences in the transport activity for organic anions across the bile canalicular membrane

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 3, 1999, Pages 1324-1330

  Ishizuka, Hitoshi ^a   Konno, Kumiko ^a   Shiina, Tetsuo ^a   Naganuma, Hideo ^a   Nishimura, Kenji ^a   Ito, Kousei ^b   Suzuki, Hiroshi ^b   Sugiyama, Yuichi ^b  

^a DAIICHI SANKYO CO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; ANION; CARRIER PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUTATHIONE DERIVATIVE; TEMOCAPRILAT; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DOG; DRUG CLEARANCE; DRUG TRANSPORT; GUINEA PIG; INTRAHEPATIC BILE DUCT; INTRAVENOUS DRUG ADMINISTRATION; LIVER HOMOGENATE; MALE; MEMBRANE TRANSPORT; MEMBRANE VESICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SPECIES DIFFERENCE; TRANSPORT KINETICS;

ANIMALS; ANION TRANSPORT PROTEINS; ANIONS; BILE CANALICULI; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CYTOSOL; DOGS; GUINEA PIGS; KINETICS; LIVER; MALE; MEMBRANES; MICE; PROTEIN BINDING; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 0032806043     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Ballatori N and Dutczak WJ (1994) Identification and characterization of high and low affinity transport systems for reduced glutathione in liver cell canalicular membranes. J Biol Chem 269:19731-19737.
2. Böhme M, Müller M, Leier I, Jedlitschky G and Keppler D (1994) Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 107:255-265.
3. Büchler M, König J, Brom M, Kartenbeck J, Spring H, Horie T and Keppler D (1996) cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 271:15091-15098.
4. Chatfield DH and Green JN (1978) Disposition and metabolism of benoxaprofen in laboratory animals and man. Xenobiotica 8:133-144.
5. Dedrick RL, Bischoff KB and Zaharko DZ (1970) Interspecies correlation of plasma concentration history of methotrexate (NSC-740). Cancer Chemother Rep. Part 1 54:95-101.
6. Duggan DE, Hooke KH, Noll RM and Kwan KC (1975) Enterohepatic circulation of indomethacin and its role in intestinal irritation. Biochem Pharmacol 25:1749-1754.
7. Evers R, Kool M, van Deemter L, Jassen H, Calafat J, Oomen LC, Paulusma CC, Oude Elferink RP, Baas F, Schinkel AH and Borst P (1998) Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest 101:1310-1319.
8. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF and Meier PJ (1998) The sister of p-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 273:10046-10050.
9. Goldberg DM (1980) Structural, functional and clinical aspects of γ-glutamyl transerase. Crit Rev Clin Lab Sci 12:1-58.
10. Hirohashi T, Suzuki H, Ito K, Ogawa K, Kume K, Shimizu T and Sugiyama Y (1998) Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Mol Pharmacol 53:1068-1075.
11. Ishikawa T, Mullar M, Klunemann C, Schaub T and Keppler D (1990) ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. J Biol Chem 265:19279-19286.
12. Ishizuka H, Konno K, Naganuma H, Sasahara K, Kawahara Y, Niinuma K, Suzuki H and Sugiyama Y (1997) Temocaprilat, a novel angiotensin converting enzyme inhibitor, is excreted into bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyper-bilirubinemic mutant rats (EHBR). J Pharmacol Exp Ther 280:1304-1311.
13. Ishizuka H, Konno K, Naganuma H, Nishimura K, Kouzuki H, Suzuki H, Stieger B, Meier PJ and Sugiyama Y (1998) Transport of temocaprilat into rat hepatocytes: Role of organic anion transporting polypeptide. J Pharmacol Exp Ther. 287:37-42.
14. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y (1996) Expression of a putative ATP-binding cassette region, homologous to that in multidrug resistance associated protein (MRP), is hereditary defective in Eisai hyperbilirubinemic rats (EHBR). Int Hepatol Commun 4:291-298.
15. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y (1997) Molecular cloning of canalicular multispecific anion transporter defective in Eisai hyperbilirubinemic rats. Am J Physiol 272:G16-G22.
16. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y (1998a) Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J Biol Chem 273:1684-1688.
17. Ito K, Iwatsubo T, Kanamitsu S, Nakajima Y and Sugiyama Y (1998b) Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport. Annu Rev Pharmacol Toxicol 38:461-499.
18. Iwatsubo T, Hirota N, Ooie T, Suzuki H, Shimada N, Chiba K, Ishizaki T, Green CE, Tyson CA and Sugiyama Y (1997) Prediction of in vivo metabolism in the human liver from in vitro metabolism data. Pharmacol Ther 73:147-171.
19. Kanno T, Maekawa M, Kanda S, Kohno H and Sudo K (1984) Evaluation of cytosolic aminopeptidase in human sera, evaluation in hepatic disorders. Am J Clin Pathol 82:700-705.
20. Keppler D and König J (1997) Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J 11:509-616.
21. Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA and Sugiyama Y (1998) cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett 433:149-162.
22. Kobayashi K, Sogame Y, Hara H and Hayashi K (1990) Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J Biol Chem 268:7737-7741.
23. Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F and Borst P (1997) Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57:3537-3547.
24. Kusuhara H, Suzuki H and Sugiyama Y (1998) The role of p-glycoprotein and canalicular multispecific organic anion transporter (cMOAT) in the hepatobiliary excretion of drugs. J Pharm Sci 87:1025-1040.
25. Levi AJ, Gatmaitan Z and Arias IM (1969) Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions. J Clin Invest 48:2156-2167.
26. Madon J, Eckhardt U, Gerloff T, Stieger B and Meier PJ (1997) Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. FEBS Lett 406:75-78.
27. Müller M and Jansen PLM (1997) Molecular aspects of hepatobiliary transport. Am J Physiol 272:G1285-G1303.
28. Niinuma K, Kato Y, Suzuki H, Tyson CA, Weizer V, Dabbs JE, Froelich R, Green CE and Sugiyama Y (1999) Primary active transport of organic anions on bile canalicular membrane in humans. Am J Physiol 276:G1153-G1164.
29. Oude Elferink RPJ, Meijer DKF, Kuipers F, Jansen PLM, Groen AK and Groothuis GMM (1995) Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268.
30. Oude Elferink RPJ, Tytgat GNJ and Groen AK (1997) The role of mdr2 P-glycoprotein in hepatobiliary lipid transport. FASEB J 11:19-28.
31. Paulusma CC, Bosma PJ, Zaman GJR, Bakker CTM, Otter M., Scheffer GL, Scheper RSJ, Borst P and Oude Elferink PJ (1996) Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science (Wash DC) 271:1126-1128.
32. Saxena M and Henderson GB (1995) ATP-dependent efflux of 2,4-dinitrophenyl-S-glutathione. J Biol Chem 270:5312-5319.
33. Sugiyama Y, Yamada T and Kaplowitz N (1981) Glutathione S-transferase in elasmobranch liver: Molecular heterogeneity, catalytic and binding properties and purification. Biochem J 199:749-756.
34. Suzuki H, Kawaratani T, Shioya H, Uji Y and Saruta T (1993) Study on pharmaco-kinetics of a new biliary excreted oral angiotensin converting enzyme inhibitor, temocapril (CS-622) in humans. Biopharm Drug Dispos 14:41-50.
35. Suzuki H and Sugiyama Y (1999) Transporters for bile acids and organic anions, in Membrane Transporters as Drug Targets (Amidon G and Sadde W eds) Plenum Publishing, New York, in press.
36. Takenaka O, Horie T, Kobayashi K, Suzuki H and Sugiyama Y (1995) Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia. Pharm Res 12:1746-1755.
37. van Aubel RA, van Kuijck MA, Koenderink JB, Deen PMT, van Os CH and Russel FG (1998) Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells. Mol Pharmacol 53:1062-1067.
38. Yamazaki M, Akiyama S, Ni'inuma K, Nishigaki RH and Sugiyama Y (1997) Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos 26:1123-1129.
39. Yamazaki M, Suzuki H and Sugiyama Y (1996) Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm Res 13:497-513.