A novel theory: Biological processes mostly involve two types of mediators, namely general and specific mediators: Endogenous small radicals such as superoxide and nitric oxide may play a role of general mediator in biological processes

Medical Hypotheses

Volumn 65, Issue 4, 2005, Pages 728-735

  Mo, Jian ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; CAROTENOID; CYTOKINE; ENZYME; FREE RADICAL; ICOSANOID; NITRIC OXIDE; SCAVENGER; SUPEROXIDE; TRANSCRIPTION FACTOR;

ARTICLE; BIOLOGICAL ACTIVITY; CELL ACTIVITY; CLASSIFICATION; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MEDIATOR; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR SIZE; MOLECULE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROPHYLAXIS; REGULATORY MECHANISM; THEORETICAL STUDY;

MODELS, BIOLOGICAL; NITRIC OXIDE; PHYSIOLOGICAL PROCESSES; SUPEROXIDES;

EID: 22644433933     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.03.028     Document Type: Article

References (90)

1. Mo J. editor. Introduction to free radical biology. Beijing: People's Medical Publishing House; 1989.
2. Wulf Droge Free radical in the physiological control of cell function Phys Rev 82 1 2002 47 95
3. J. Mo, J. Fan, Z. Guo, C. Huang, B. Yan, and F. Wang A new hypothesis about the relationship between free radical reactions and hemorheological properties in vivo Med Hypotheses 41 6 1993 516 520
4. B. Halliwell, and J.M.C. Gutteridge The importance of free radicals and catalytic metal ions in human diseases Mol Aspect Med 8 2 1985 89 193
5. Bruce N. Ames, Mark K. Shigenaga, and Tory M. Hagen Oxidants, antioxidants, and the degenerative diseases of aging Proc Natl Sci USA 90 1993 7915 7922
6. Bruce A. Freeman, and James D. Crapo Free radicals and tissue injury Lab Invest 47 5 1982 412 426
7. S. Moncada, R.M. Palmer, and E.A. Higgs Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol Rev 43 2 1991 109 142
8. C.H. Evens, M. Stefanovie-Racic, and J. Lancaster Nitric oxide and its role in orthopaedic disease Clinic Orthopaedies Res. 312 1995 275 294
9. Carl Nathan Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling J Clin Invest 111 2003 769 776
10. Yi Sun, and Larry W Oberley Redox regulation of transcriptional activators Free Rad Biol Med 21 3 1996 335 348
11. A. DelaTorre, R.A. Schroeder, and P.C. Kuo Alteration of NF-kappa B p50 DNA binding kinetics by S-nitrosylation Biochem Biophys Res Commun 238 3 1997 703 706
12. L. Castro, M. Rodriguez, and R. Radi Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide J Biol Chem 269 47 1994 29409 29415
13. L. Cardner, I. Raineri, L.B. Epstein, and C.W. White Superoxide radical and iron modulate aconitase activity in mammalian cells J Biol Chem 270 22 1995 13399 13405
14. B. Brune, and E.G. Lapetina Protein thiol modification of glyceraldehyde-3-phosphate dehydrogenase as a target for nitric oxide signaling Genet Eng NY 17 1995 149 164
15. O. Khatsenko Interactions between nitric oxide and cytochrome P-450 in the liver Biochem Mosc 63 7 1998 833 839
16. L. Tenneti, D.M. D'Emilia, and S.A. Lipton Suppression of neuronal apoptosis by S-nitrosylation of caspases Neurosci Lett 236 3 1997 139 142
17. C. Ducrocq, M. Dendane, O. Laprevote, L. Serani, B.C. Das, and N. Bouchemal Chibani Chemical modifications of the vasoconstrictor peptide angiotensin II by nitrogen oxides (NO, HNO2, HOONO) - evaluation by mass spectrometry Eur J Biochem 253 1 1998 146 153
18. Y. Zhao, Y. Xue, T.-D. Oberley, K.-K. Kiningham, S.-M. Lin, and H.-C. Yen Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model Cancer Res 61 16 2001 6082 6088
19. K. Furuke, M. Shiraishi, H.S. Mostowski, and E.T. Bloom Fas ligand induction in human NK cells is regulated by redox through a calcineurin-nuclear factors of activated T cell-dependent pathway J Immunol 162 4 1999 1988 1993
20. D. Gius, A. Botero, S. Shah, and H.A. Curry Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1 Toxicol Lett 106 2-3 1999 93 106
21. Y. Suzuki, and Y. Ono Serum factors and the cellular redox status regulate cellular responsiveness to MHC class II-triggered homotypic B cell adhesion Biochem Biophys Res Commun 249 1 1998 31 37
22. S.K. Manna, H.J. Zhang, T. Yan, L.W. Oberley, and B.B. Aggarwal Overexpression of manganes superoxide dismutase supresses tumor necrosis factor - induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1 J Biol Chem 273 21 1998 13245 13254
23. M.N. Ajuebor, L. Virag, R.J. Flower, M. Peretti, and C. Szabo Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation Immunology 95 4 1998 625 630
24. J. Torreilles Nitrix oxide: one of the conserved and widespread signaling molecules Front Biosci 6 2001 [116-11172B055,104/2662]
25. R. Cannio, G. Fiorentino, A. Morana, M. Rossi, and S. Bartolucci Oxygen: friend or foe? Archaeal superoxide dismutases in the protection of intra- and extracellular oxidative stress Front Biosci 5 2000 D768 D779
26. Roy J. Soberman Serious introduction: the expanding network of redox signaling: new observations, complexities and perspectives J Clin Invest 111 2003 571 574
27. H.J. Palmer, and K.E. Paulson Reactive oxygen species and antioxidants in signal transduction and gene expression Nutri Rev 55 10 1997 353 361
28. Toshfumi Matsuyama, Nobuyuki, and Naoki Yamamoto Cytokines and HIV infection: is AIDS a tumor necrosis factor disease AIDS 5 12 1991 1405 1417
29. Karen L. davis, Emil Martin, Warion Vturko, and Forid Mural Novel effects of nitric oxide Ann Rev Pharmacol Toxicol 41 2001 203 236
30. Danieffe Mors, and Augustine M.K. Chol Heme oxygenase-1: the "emerging molecule" has arrived Am J Respiratory cell Mol Biol 27 1 2002 8 16
31. Richard J. Rogers, Joan M. Monnier, and Harry S. Nick Tumor necrosis factor selectively induces MnSOD expression via mitochondria - to - nucleus signaling, whereas interleukin-1 utilizes an alternative pathway J Biol Chem 276 23 2001 20419 20427
32. A. Ramachandran, A.L. Levonen, P.S. Brockes, E. Ceaser, S. Shiva, and M.C. Barone Mitochondria, nitric oxide and cardiovascular dysfunction Free Rad Biol Med 33 11 2002 1465 1467
33. Wolin Michael S., Gute Sachin A., and Oeckler Richard A. Superoxide in the vascular system J Vascular Res 39 3 2002 191 207
34. K.K. Griending, D. Sosen, B. Lassegue, and M. Ushio-Fukai Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology Arterioscler Throm Vasc Biol 20 10 2000 2178 2183
35. Irani Kaikobar Oxidant signaling in vascular cell growth, death and survival Circ Res 87 5 2000 179 183
36. M.J. Marinissen, and J.S. Gutkind G-protein coupled receptors and signaling networks: emerging paradigms Trends Pharmacol Sci 22 7 2001 368 376
37. Hugo P. Monteiro, and Arnold Stern Redox modulation of tyrosine phospharylation-dependent signal transduction pathways Free Rad Biol Med 21 3 1996 323 333
38. J. Knight A review: free radicals, antioxidants, and the immune system Ann Clin Lab Sci 30 2 2000 145 158
39. N. Miyasaka, and Y. Hirata Nitric oxide and inflammatory arthritides Life Sci 61 21 1997 2073 2081
40. F. Ribeiro Dias, M. Russo, F.R. Nascimento, J.A. Barbuto, J. Timenetsky, and S. Jancar Thioglycollate-elicited murine macrophages are cytotoxic to Mycoplasma arginini-infected YAC-1 tumor cells Braz J Med Biol Res 31 11 1998 1425 1428
41. K. Suzuki, W.J. Lee, T. Hashimoto, E. Tanaka, T. Murayama, and R. Amitani Recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) or tumour necrosis factor-alpha (TNF-alpha) activate human alveolar macrophages to inhibit growth of Mycobacterium avium complex Clin Exp Immunol 98 1 1994 169 173
42. S.H. Oliveira, S.G. Fonseca, P.R. Romao, F. Figueiredo, S.H. Ferreira, and F.Q. Cunha Microbicidal activity of eosinophils is associated with activation of the arginine-NO pathway Parasite Immunol 20 9 1998 405 412
43. A.S. Heiman, and D. Allen Gipson Cytokines potentiate human eosinophil superoxide generation in the presence of N(omega)-nitro-l-arginine methyl ester Int J Immunopharmacol 22 2 2000 171 181
44. Y. Motegi, H. Kita, M. Kato, and A. Morikawa Role of secretory IgA, secretory component, and eosinophils in mucosal inflammation Int Arch Allergy Immunol 122 Suppl 2000 125 127
45. Y. Motegi, and H. Kita Interaction with secretory component stimulates effector functions of human eosinophils but not of neutrophils J Immunol 161 8 1998 4340 4346
46. K.R. Bartemes, S. McKinney, G.J. Gleich, and H. Kita Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG J Immunol 162 5 1999 2982 2989
47. S. Okada, J.B. Hagan, M. Kato, J.L. Bankers Fulbright, L.W. Hunt, and G.J. Gleich Lidocaine and its analogues inhibit IL-5-mediated survival and activation of human eosinophils J Immunol 160 8 1998 4010 4017
48. T. Doi, N. Motoyama, A. Tokunaga, and T. Watanabe Death signals from the B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascades in a murine B cell line, WEHI-231 Int Immunol 11 6 1999 933 941
49. M. Nagata, J.B. Sedgwick, and W.W. Busse Synergistic activation of eosinophil superoxide anion generation by VCAM-1 and GM-CSF. Involvement of tyrosine kinase and protein kinase C Int Arch Allergy Immunol 114 Suppl. 1997 178 180
50. S.H. Oliveira, S.G. Fonseca, P.R. Romao, F. Figueiredo, S.H. Ferreira, and F.Q. Cunha Microbicidal activity of eosinophils is associated with activation of the arginine-NO pathway Parasite Immunol 20 9 1998 405 412
51. Satish Devadas, Luba Zaritskaya, Suem Goo Rhee, Larry Oberley, and S. Williams Mark Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression J Exp Med 195 1 2002 59 70
52. A.W. Taylor Robinson Counter-regulation of T helper 1 cell proliferation by nitric oxide and interleukin-2 Biochem-Biophys-Res-Commun 233 1 1997 14 19
53. J.R. Lee, and G.A. Koretzky Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes Eur J Immunol 28 12 1998 4188 4197
54. M.G. Cifone, S. D'Alo, R. Parroni, D. Millimaggi, L. Biordi, and S. Martinotti Interleukin-2-activated rat natural killer cells express inducible nitric oxide synthase that contributes to cytotoxic function and interferon-gamma production Blood 93 11 1999 3876 3884
55. M.D. Jyothi, and A. Khar Interleukin-2-induced nitric oxide synthase and nuclear factor-kappaB activity in activated natural killer cells and the production of interferon-gamma Scand J Immunol 52 2 2000 148 155
56. M.D. Jyothi, and A. Khar Induction of nitric oxide production by natural killer cells: its role in tumor cell death Nitric Oxide 3 5 1999 409 418
57. Peterson JD, Herzenberg LA, Vasquez K, Waltenbaugh C. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci USA 1998 17;95 (6):3071-3076.
58. K. Rutault, C. Alderman, B.M. Chain, and D.R. Katz Reactive oxygen species activate human peripheral blood dendritic cells Free Radic Biol Med 26 1-2 1999 232 238
59. D. Piganelli Jon, C. Flores Sonia, Coral Cruz, Jeffrey Koepp, Haberle Ines Batinic, and James Crapo A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone Diabetes 51 2 2002 347 355
60. L. Pricopm, J. Gokhale, P. Redecha, S.C. Ng, and J.E. Salmon Reactive oxygen intermediates enhance Fc gamma receptor signaling and amplify phagocytic capacity J Immunol 162 12 1999 7041 7048
61. K. Nakamura, and K. Matsunaga Susceptibility of natural killer (NK) cells to reactive oxygen species (ROS) and their restoration by the mimics of superoxide dismutase (SOD) Cancer Biother Radiopharm 13 4 1998 275 290
62. R.L. Kridin, H.W. Liu, N. van-Rooijen, K. Springer, L.H. Zhao, and C.P. Leary Pulmonary immunity to Listeria is enhanced by elimination of alveolar macrophages Am J Respir Crit Care Med 159 6 1999 1967 1974
63. W. Niedbala, X.Q. Wei, D. Piedrafita, D. Xu, and F.Y. Liew Effects of nitric oxide on the induction and differentiation of Th1 cells Eur J Immunol 29 8 1999 2498 2505
64. J. Marcinkiewicz Nitric oxide and antimicrobial activity of reactive oxygen intermediates Immunopharmacology 37 1 1997 35 41
65. E. Hidalgo, and B. Demple Activation of SoxR-dependent transcription in vitro by noncatalytic or NifS-mediated assembly of [2Fe-2S] clusters into apo-SoxR J Biol Chem 271 13 1996 7269 7272
66. P. Klatt, E.P. Molina, and S. Lamas Nitric oxide inhibits c-Jun DNA binding by specifically targeted S-glutathionylation J Biol Chem 274 22 1999 15857 15864
67. P.M. Bauer, G.M. Buga, J.M. Fukuto, A.E. Pegg, and L.J. Ignarro Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme J Biol Chem 276 37 2001 34458 34464
68. B.Y. Kim, M.J. Han, and A.S. Chung Effects of reactive oxygen species on proliferation of Chinese hamster lung fibroblast (V79) cells Free Radic Biol Med 30 2001 686 688
69. R.A. Oeckler, and M.S. Wolin Stretch enhances contractile responses in bovine coronary and pulmonary arteries: Potential role of NADH oxidase-derived peroxide and activation of the ERK MAP kinase cascade Circulation 104 2001 11 605 (abstract)
70. T.P. Garrington, and G.L. Johnson Organization and regulation of mitogen-activated protein kinase signaling pathways Curr Opin Cell Biol 11 1999 211 218
71. S. Stewart, M. Sundaram, Y. Zhang, J. Lee, M. Han, and K.L. Guan Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization Mol Cell Biol 19 1999 5523 5534
72. K. Helmbrecht, E. Zeise, and L. Rensing Chaperones in cell cycle regulation and mitogenic signal transduction: a review Cell Prolif 33 2000 341 365
73. P.T. Nowicki, S. Flavahan, H. Hassanain, S. Mitra, S. Holland, and P.J. Goldschmidt-Clermont Redox signaling of the arteriolar myogenic response Circ Res 89 2001 114 116
74. S.L. Lee, A.R. Simon, W.W. Wang, and B.L. Fanburg H202 signals 5-HT-induced ERK MAP kinase activation and mitogenesis of smooth muscle cells Am J Physiol Lung Cell Mol Physiol 281 2001 L646 L652
75. K. Takakura, J.S. Beckman, L.A. MacMillan-Crow, and J.P. Crow Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite Arch Biochem Biophys 369 1999 197 207
76. W.C. Barrett, J.P. DeGnore, Y.F. Keng, Z.Y. Zhang, M.B. Yim, and P.B. Chock Roles of superoxide radical anion in signal transduction mediated by reversible regulation of protein-tyrosine phosphatase lB J Biol Chem 274 1999 34543 34546
77. D. Callsen, K.B. Sandau, and B. Brune Nitric oxide and superoxide inhibit platelet-derived growth factor receptor phosphotyrosine phosphatases Free Radic Biol Med 26 1999 1544 1553
78. K.M. Lounsbury, Q. Hu, and R.C. Ziegelstein Calcium signaling and oxidant stress in the vasculature Free Radic Biol Med 28 2000 1362 1369
79. S.J. Elliott, and S.K. Koliwad Redox control of ion channel activity in vascular endothelial cells by glutathione Microcirculation 4 1997 341 347
80. Roy J. Soberman Serious introduction: the expanding network of redox signaling: new observation, complexities, and perspectives J Clin Invest 111 2003 571 574
81. J.S. Hardwick, and B.M. Sefton The activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen peroxide is phosphorylated at both Tyr-394 and Tyr-505 J Biol Chem 272 41 1997 25429 25432
82. F. Yamakura, H. Taka, T. Fujimura, and K. Murayama Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine J Biol Chem 273 23 1998 14085 14089
83. M. Zou, A. Yesilkaya, and V. Ullrich Peroxynitrite inactivates prostacyclin synthase by heme-thiolate-catalyzed tyrosine nitration Drug Metab Rev 31 2 1999 343 349
84. B. Roy, M. Lepoivre, Y. Henry, and M. Fontecave Inhibition of ribonucleotide reductase by nitric oxide derived from thionitrites: reversible modifications of both subunits Biochemistry 34 16 1995 5411 5418
85. M. Casadevall, and B. Sarkar Effect of redox conditions on the DNA-binding efficiency of the retinoic acid receptor zinc-finger J Inorg Biochem 71 3-4 1998 147 152
86. D.A. Wink, and J. Laval The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo Carcinogenesis 15 10 1994 2125 2129
87. K. Nose, and M. Ohba Functional activation of the egr-1 gene by hydrogen peroxidase Biochem J 316 pt 2 1996 381 383
88. L.T. Knapp, and E. Klann Superoxide-induced stimulation of protein kinase C via thiol modification and modulation of zinc content J Biol Chem 275 2000 24136 24145
89. T. Matsuyama, S. Yoshikawa, N. Nakagawa, H. Yagi, S. Yamamoto, and S. Linuma Effect of phosphatidylcholine-superoxide dismutase (PC-SOD) on acute gastric mucosal injury induce by ischemia/reperfusion in rats Kozi Asada Toshikazu Yoshikawa Frontiers of reactive oxygen species in biology and medicine 1994 Excepta Medica Amsterdam-London-NewYork-Tokyo 427 428
90. T. Nishimura, Y. Yoshikawa, K. Naito, Matsuyama, and M. Konda Protection by exogenous nitric oxide and SOD against gastric mucosal injury induced by ischemia/reperfision in rats Kozi Asada Toshikazu Yoshikawa Frontiers of reactive oxygen species in biology and medicine 1994 Excepta Medica Amsterdam-London-NewYork-Tokyo 235 236