Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability

Gastroenterology

Volumn 129, Issue 1, 2005, Pages 74-85

  Schulmann, Karsten ^a,c   Mori, Yuriko ^a   Croog, Victoria ^d   Yin, Jing ^a   Olaru, Andreea ^a   Sterian, Anca ^a   Sato, Fumiaki ^a   Wang, Suna ^a   Xu, Yan ^a   Deacu, Elena ^a   Berki, Agnes T ^a   Hamilton, James P ^a   Kan, Takatsugu ^a   Abraham, John M ^a   Schmiegel, Wolff ^c   Harpaz, Noam ^d   Meltzer, Stephen J ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1; RAB PROTEIN;

ARTICLE; CANCER RISK; COLON CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; CROHN DISEASE; EPITHELIUM DYSPLASIA; FRAMESHIFT MUTATION; GENE FREQUENCY; GENE TARGETING; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN TISSUE; MICROSATELLITE INSTABILITY; MUTATIONAL ANALYSIS; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; STOMACH CARCINOMA; ULCERATIVE COLITIS;

EID: 22344434975     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.04.011     Document Type: Article

References (102)

1. A. Ekbom, C. Helmick, M. Zack, H.O. Adami Ulcerative colitis and colorectal cancer. A population-based study N Engl J Med 323 1990 1228 1233
2. C.N. Bernstein, J.F. Blanchard, E. Kliewer, A. Wajda Cancer risk in patients with inflammatory bowel disease a population-based study Cancer 91 2001 854 862
3. J.A. Eaden, K.R. Abrams, J.F. Mayberry The risk of colorectal cancer in ulcerative colitis a meta-analysis Gut 48 2001 526 535
4. J. Askling, P.W. Dickman, P. Karlen, O. Brostrom, A. Lapidus, R. Lofberg, A. Ekbom Family history as a risk factor for colorectal cancer in inflammatory bowel disease Gastroenterology 120 2001 1356 1362
5. K.W. Nuako, D.A. Ahlquist, D.W. Mahoney, D.J. Schaid, D.M. Siems, N.M. Lindor Familial predisposition for colorectal cancer in chronic ulcerative colitis a case-control study Gastroenterology 115 1998 1079 1083
6. K.W. Nuako, D.A. Ahlquist, W.J. Sandborn, D.W. Mahoney, D.M. Siems, A.R. Zinsmeister Primary sclerosing cholangitis and colorectal carcinoma in patients with chronic ulcerative colitis a case-control study Cancer 82 1998 822 826
7. U. Broome, R. Lofberg, B. Veress, L.S. Eriksson Primary sclerosing cholangitis and ulcerative colitis evidence for increased neoplastic potential Hepatology 22 1995 1404 1408
8. D. Kornfeld, A. Ekbom, T. Ihre Is there an excess risk for colorectal cancer in patients with ulcerative colitis and concomitant primary sclerosing cholangitis? A population based study Gut 41 1997 522 525
9. M. Rutter, B. Saunders, K. Wilkinson, S. Rumbles, G. Schofield, M. Kamm, C. Williams, A. Price, I. Talbot, A. Forbes Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis Gastroenterology 126 2004 451 459
10. D.B. Sachar Cancer in Crohn's disease dispelling the myths Gut 35 1994 1507 1508
11. N. Harpaz, I.C. Talbot Colorectal cancer in idiopathic inflammatory bowel disease Semin Diagn Pathol 13 1996 339 357
12. S.H. Itzkowitz, N. Harpaz Diagnosis and management of dysplasia in patients with inflammatory bowel diseases Gastroenterology 126 2004 1634 1648
13. E.R. Fearon, B. Vogelstein A genetic model for colorectal tumorigenesis Cell 61 1990 759 767
14. F.M. Selaru, Y. Xu, J. Yin, T. Zou, T.C. Liu, Y. Mori, J.M. Abraham, F. Sato, S. Wang, C. Twigg, A. Olaru, V. Shustova, A. Leytin, P. Hytiroglou, D. Shibata, N. Harpaz, S.J. Meltzer Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions Gastroenterology 122 2002 606 613
15. C.E. Rubin, R.C. Haggitt, G.C. Burmer, T.A. Brentnall, A.C. Stevens, D.S. Levine, P.J. Dean, M. Kimmey, D.R. Perera, P.S. Rabinovitch DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis Gastroenterology 103 1992 1611 1620
16. R. Porschen, U. Robin, A. Schumacher, S. Schauseil, F. Borchard, K.J. Hengels, G. Strohmeyer DNA aneuploidy in Crohn's disease and ulcerative colitis results of a comparative flow cytometric study Gut 33 1992 663 667
17. J.O. Lindberg, R.B. Stenling, J.N. Rutegard DNA aneuploidy as a marker of premalignancy in surveillance of patients with ulcerative colitis Br J Surg 86 1999 947 950
18. R. Keller, E.C. Foerster, A. Kohler, B. Floer, G. Winde, H.J. Terpe, W. Domschke Diagnostic value of DNA image cytometry in ulcerative colitis Dig Dis Sci 46 2001 870 878
19. K. Holzmann, B. Klump, F. Borchard, M. Gregor, R. Porschen Flow cytometric and histologic evaluation in a large cohort of patients with ulcerative colitis correlation with clinical characteristics and impact on surveillance Dis Colon Rectum 44 2001 1446 1455
20. B.D. Greenwald, N. Harpaz, J. Yin, Y. Huang, Y. Tong, V.L. Brown, T. McDaniel, C. Newkirk, J.H. Resau, S.J. Meltzer Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis Cancer Res 52 1992 741 745
21. R.F. Willenbucher, D.E. Aust, C.G. Chang, S.J. Zelman, L.D. Ferrell, D.H. Moore II, F.M. Waldman Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia Am J Pathol 154 1999 1825 1830
22. R.F. Willenbucher, S.J. Zelman, L.D. Ferrell, D.H. Moore II, F.M. Waldman Chromosomal alterations in ulcerative colitis-related neoplastic progression Gastroenterology 113 1997 791 801
23. D.E. Aust, R.F. Willenbucher, J.P. Terdiman, L.D. Ferrell, C.G. Chang, D.H. Moore II, A. Molinaro-Clark, G.B. Baretton, U. Loehrs, F.M. Waldman Chromosomal alterations in ulcerative colitis-related and sporadic colorectal cancers by comparative genomic hybridization Hum Pathol 31 2000 109 114
24. R.D. Odze, C.A. Brown, C.J. Hartmann, A.E. Noffsinger, F. Fogt Genetic alterations in chronic ulcerative colitis-associated adenoma-like DALMs are similar to non-colitic sporadic adenomas Am J Surg Pathol 24 2000 1209 1216
25. R.D. Odze, T. Brien, C.A. Brown, C.J. Hartman, A. Wellman, F. Fogt Molecular alterations in chronic ulcerative colitis-associated and sporadic hyperplastic polyps a comparative analysis Am J Gastroenterol 97 2002 1235 1242
26. F. Fogt, A.O. Vortmeyer, H. Goldman, T.J. Giordano, M.J. Merino, Z. Zhuang Comparison of genetic alterations in colonic adenoma and ulcerative colitis-associated dysplasia and carcinoma Hum Pathol 29 1998 131 136
27. F. Fogt, A.O. Vortmeyer, M. Stolte, E. Mueller, J. Mueller, A. Noffsinger, C. Poremba, Z. Zhuang Loss of heterozygosity of the von Hippel Lindau gene locus in polypoid dysplasia but not flat dysplasia in ulcerative colitis or sporadic adenomas Hum Pathol 29 1998 961 964
28. F. Fogt, S.J. Urbanski, M.E. Sanders, E.E. Furth, R.L. Zimmerman, J.J. Deren, A.E. Noffsinger, A.O. Vortmeyer, C.J. Hartmann, R.L. Odze, C.A. Brown Distinction between dysplasia-associated lesion or mass (DALM) and adenoma in patients with ulcerative colitis Hum Pathol 31 2000 288 291
29. F. Fogt, Z. Zhuang, C. Poremba, B. Dockhorn-Dworniczak, A. Vortmeyer Comparison of p53 immunoexpression with allelic loss of p53 in ulcerative colitis-associated dysplasia and carcinoma Oncol Rep 5 1998 477 480
30. J. Yin, N. Harpaz, Y. Tong, Y. Huang, J. Laurin, B.D. Greenwald, M. Hontanosas, C. Newkirk, S.J. Meltzer p53 point mutations in dysplastic and cancerous ulcerative colitis lesions Gastroenterology 104 1993 1633 1639
31. S.P. Hussain, P. Amstad, K. Raja, S. Ambs, M. Nagashima, W.P. Bennett, P.G. Shields, A.J. Ham, J.A. Swenberg, A.J. Marrogi, C.C. Harris Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis a cancer-prone chronic inflammatory disease Cancer Res 60 2000 3333 3337
32. T.A. Brentnall, D.A. Crispin, P.S. Rabinovitch, R.C. Haggitt, C.E. Rubin, A.C. Stevens, G.C. Burmer Mutations in the p53 gene an early marker of neoplastic progression in ulcerative colitis Gastroenterology 107 1994 369 378
33. G.C. Burmer, P.S. Rabinovitch, R.C. Haggitt, D.A. Crispin, T.A. Brentnall, V.R. Kolli, A.C. Stevens, C.E. Rubin Neoplastic progression in ulcerative colitis histology, DNA content, and loss of a p53 allele Gastroenterology 103 1992 1602 1610
34. L. Tarmin, J. Yin, N. Harpaz, M. Kozam, J. Noordzij, L.B. Antonio, H.Y. Jiang, O. Chan, K. Cymes, S.J. Meltzer Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms Cancer Res 55 1995 2035 2038
35. D.E. Aust, J.P. Terdiman, R.F. Willenbucher, C.G. Chang, A. Molinaro-Clark, G.B. Baretton, U. Loehrs, F.M. Waldman The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas a mutational analysis Cancer 94 2002 1421 1427
36. N. Umetani, S. Sasaki, T. Watanabe, M. Shinozaki, K. Matsuda, H. Ishigami, E. Ueda, T. Muto Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability Jpn J Cancer Res 90 1999 1081 1087
37. N. Harpaz, A.L. Peck, J. Yin, I. Fiel, M. Hontanosas, T.R. Tong, J.N. Laurin, J.M. Abraham, B.D. Greenwald, S.J. Meltzer p53 protein expression in ulcerative colitis-associated colorectal dysplasia and carcinoma Hum Pathol 25 1994 1069 1074
38. A.T. Hoque, S.A. Hahn, M. Schutte, S.E. Kern DPC4 gene mutation in colitis associated neoplasia Gut 40 1997 120 122
39. J. Lei, T.T. Zou, Y.Q. Shi, X. Zhou, K.N. Smolinski, J. Yin, R.F. Souza, R. Appel, S. Wang, K. Cymes, O. Chan, J.M. Abraham, N. Harpaz, S.J. Meltzer Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms Oncogene 13 1996 2459 2462
40. S.J. Meltzer, S.M. Mane, P.K. Wood, J.H. Resau, C. Newkirk, J.A. Terzakis, B.I. Korelitz, W.M. Weinstein, S.W. Needleman Activation of c-Ki-ras in human gastrointestinal dysplasias determined by direct sequencing of polymerase chain reaction products Cancer Res 50 1990 3627 3630
41. G.C. Burmer, D.S. Levine, B.G. Kulander, R.C. Haggitt, C.E. Rubin, P.S. Rabinovitch c-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma Gastroenterology 99 1990 416 420
42. S.M. Bell, S.A. Kelly, J.A. Hoyle, F.A. Lewis, G.R. Taylor, H. Thompson, M.F. Dixon, P. Quirke c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis Br J Cancer 64 1991 174 178
43. P. Chaubert, J. Benhattar, E. Saraga, J. Costa K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis Am J Pathol 144 1994 767 775
44. M.H. Lyda, A. Noffsinger, J. Belli, C.M. Fenoglio-Preiser Microsatellite instability and K-ras mutations in patients with ulcerative colitis Hum Pathol 31 2000 665 671
45. A.S. Fleisher, M. Esteller, N. Harpaz, A. Leytin, A. Rashid, Y. Xu, J. Liang, O.C. Stine, J. Yin, T.T. Zou, J.M. Abraham, D. Kong, K.T. Wilson, S.P. James, J.G. Herman, S.J. Meltzer Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1 Cancer Res 60 2000 4864 4868
46. H. Suzuki, N. Harpaz, L. Tarmin, J. Yin, H.Y. Jiang, J.D. Bell, M. Hontanosas, G.M. Groisman, J.M. Abraham, S.J. Meltzer Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers Cancer Res 54 1994 4841 4844
47. T. Ishitsuka, H. Kashiwagi, F. Konishi Microsatellite instability in inflamed and neoplastic epithelium in ulcerative colitis J Clin Pathol 54 2001 526 532
48. T.A. Brentnall, D.A. Crispin, M.P. Bronner, S.P. Cherian, M. Hueffed, P.S. Rabinovitch, C.E. Rubin, R.C. Haggitt, C.R. Boland Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis Cancer Res 56 1996 1237 1240
49. A.E. Noffsinger, J.M. Belli, F. Fogt, J. Fischer, H. Goldman, C.M. Fenoglio-Preiser A germline hMSH2 alteration is unrelated to colonic microsatellite instability in patients with ulcerative colitis Hum Pathol 30 1999 8 12
50. L. Cawkwell, F. Sutherland, H. Murgatroyd, P. Jarvis, S. Gray, D. Cross, N. Shepherd, D. Day, P. Quirke Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers Gut 46 2000 367 369
51. Y. Mori, J. Yin, A. Rashid, B.A. Leggett, J. Young, L. Simms, P.M. Kuehl, P. Langenberg, S.J. Meltzer, O.C. Stine Instabilotyping comprehensive identification of frameshift mutations caused by coding region microsatellite instability Cancer Res 61 2001 6046 6049
52. Y. Mori, J. Yin, F. Sato, A. Sterian, L.A. Simms, F.M. Selaru, K. Schulmann, Y. Xu, A. Olaru, S. Wang, E. Deacu, J.M. Abraham, J. Young, B.A. Leggett, S.J. Meltzer Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning Cancer Res 64 2004 2434 2438
53. R.H. Riddell, H. Goldman, D.F. Ransohoff, H.D. Appelman, C.M. Fenoglio, R.C. Haggitt, C. Ahren, P. Correa, S.R. Hamilton, B.C. Morson Dysplasia in inflammatory bowel disease standardized classification with provisional clinical applications Hum Pathol 14 1983 931 968
54. Y. Mori, F. Sato, F.M. Selaru, A. Olaru, K. Perry, M.C. Kimos, G. Tamura, N. Matsubara, S. Wang, Y. Xu, J. Yin, T.T. Zou, B. Leggett, J. Young, T. Nukiwa, O.C. Stine, J.M. Abraham, D. Shibata, S.J. Meltzer Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers Cancer Res 62 2002 3641 3645
55. C.R. Boland, S.N. Thibodeau, S.R. Hamilton, D. Sidransky, J.R. Eshleman, R.W. Burt, S.J. Meltzer, M.A. Rodriguez-Bigas, R. Fodde, G.N. Ranzani, S. Srivastava A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition development of international criteria for the determination of microsatellite instability in colorectal cancer Cancer Res 58 1998 5248 5257
56. F. Sato, N. Harpaz, D. Shibata, Y. Xu, J. Yin, Y. Mori, T.T. Zou, S. Wang, K. Desai, A. Leytin, F.M. Selaru, J.M. Abraham, S.J. Meltzer Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis Cancer Res 62 2002 1148 1151
57. D.M. Shibata, F. Sato, Y. Mori, K. Perry, J. Yin, S. Wang, Y. Xu, A. Olaru, F. Selaru, K. Spring, J. Young, J.M. Abraham, S.J. Meltzer Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas Cancer Res 62 2002 5637 5640
58. F. Sato, D. Shibata, N. Harpaz, Y. Xu, J. Yin, Y. Mori, S. Wang, A. Olaru, E. Deacu, F.M. Selaru, M.C. Kimos, P. Hytiroglou, J. Young, B. Leggett, A.F. Gazdar, S. Toyooka, J.M. Abraham, S.J. Meltzer Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma Cancer Res 62 2002 6820 6822
59. C.A. Eads, R.V. Lord, K. Wickramasinghe, T.I. Long, S.K. Kurumboor, L. Bernstein, J.H. Peters, S.R. DeMeester, T.R. DeMeester, K.A. Skinner, P.W. Laird Epigenetic patterns in the progression of esophageal adenocarcinoma Cancer Res 61 2001 3410 3418
60. L.J. Hofseth, M.A. Khan, M. Ambrose, O. Nikolayeva, M. Xu-Welliver, M. Kartalou, S.P. Hussain, R.B. Roth, X. Zhou, L.E. Mechanic, I. Zurer, V. Rotter, L.D. Samson, C.C. Harris The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation J Clin Invest 112 2003 1887 1894
61. B. Shannon, S. Gnanasampanthan, J. Beilby, B. Iacopetta A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability Gut 50 2002 520 524
62. R. Ward, A. Meagher, I. Tomlinson, T. O'Connor, M. Norrie, R. Wu, N. Hawkins Microsatellite instability and the clinicopathological features of sporadic colorectal cancer Gut 48 2001 821 829
63. J. Young, L.A. Simms, K.G. Biden, C. Wynter, V. Whitehall, R. Karamatic, J. George, J. Goldblatt, I. Walpole, S.A. Robin, M.M. Borten, R. Stitz, J. Searle, D. McKeone, L. Fraser, D.R. Purdie, K. Podger, R. Price, R. Buttenshaw, M.D. Walsh, M. Barker, B.A. Leggett, J.R. Jass Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings parallel pathways of tumorigenesis Am J Pathol 159 2001 2107 2116
64. J.R. Jass, K.A. Do, L.A. Simms, H. Iino, C. Wynter, S.P. Pillay, J. Searle, G. Radford-Smith, J. Young, B. Leggett Morphology of sporadic colorectal cancer with DNA replication errors Gut 42 1998 673 679
65. W.S. Park, T. Pham, C. Wang, S. Pack, E. Mueller, J. Mueller, A. Vortmeyer, Z. Zhuang, F. Fogt Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis Int J Mol Med 2 1998 221 224
66. C.L. Chang, G. Marra, D.P. Chauhan, H.T. Ha, D.K. Chang, L. Ricciardiello, A. Randolph, J.M. Carethers, C.R. Boland Oxidative stress inactivates the human DNA mismatch repair system Am J Physiol Cell Physiol 283 2002 C148 C154
67. R.F. Souza, L. Garrigue-Antar, J. Lei, J. Yin, R. Appel, V.F. Vellucci, T.T. Zou, X. Zhou, S. Wang, M.G. Rhyu, K. Cymes, O. Chan, W.S. Park, M.J. Krasna, B.D. Greenwald, J. Cottrell, J.M. Abraham, L. Simms, B. Leggett, J. Young, N. Harpaz, M. Reiss, S.J. Meltzer Alterations of transforming growth factor-beta 1 receptor type II occur in ulcerative colitis-associated carcinomas, sporadic colorectal neoplasms, and esophageal carcinomas, but not in gastric neoplasms Hum Cell 9 1996 229 236
68. R.F. Souza, R. Appel, J. Yin, S. Wang, K.N. Smolinski, J.M. Abraham, T.T. Zou, Y.Q. Shi, J. Lei, J. Cottrell, K. Cymes, K. Biden, L. Simms, B. Leggett, P.M. Lynch, M. Frazier, S.M. Powell, N. Harpaz, H. Sugimura, J. Young, S.J. Meltzer Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours Nat Genet 14 1996 255 257
69. R.F. Souza, J. Yin, K.N. Smolinski, T.T. Zou, S. Wang, Y.Q. Shi, M.G. Rhyu, J. Cottrell, J.M. Abraham, K. Biden, L. Simms, B. Leggett, G.S. Bova, T. Frank, S.M. Powell, H. Sugimura, J. Young, N. Harpaz, K. Shimizu, N. Matsubara, S.J. Meltzer Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors Cancer Res 57 1997 2350 2353
70. R.F. Souza, J. Lei, J. Yin, R. Appel, T.T. Zou, X. Zhou, S. Wang, M.G. Rhyu, K. Cymes, O. Chan, W.S. Park, M.J. Krasna, B.D. Greenwald, J. Cottrell, J.M. Abraham, L. Simms, B. Leggett, J. Young, N. Harpaz, S.J. Meltzer A transforming growth factor beta 1 receptor type II mutation in ulcerative colitis-associated neoplasms Gastroenterology 112 1997 40 45
71. S.A. Kuismanen, A.L. Moisio, P. Schweizer, K. Truninger, R. Salovaara, J. Arola, R. Butzow, J. Jiricny, M. Nystrom-Lahti, P. Peltomaki Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability Am J Pathol 160 2002 1953 1958
72. A. Duval, M. Reperant, R. Hamelin Comparative analysis of mutation frequency of coding and non coding short mononucleotide repeats in mismatch repair deficient colorectal cancers Oncogene 21 2002 8062 8066
73. A. Duval, S. Rolland, A. Compoint, E. Tubacher, B. Iacopetta, G. Thomas, R. Hamelin Evolution of instability at coding and non-coding repeat sequences in human MSI-H colorectal cancers Hum Mol Genet 10 2001 513 518
74. A. Duval, R. Hamelin Mutations at coding repeat sequences in mismatch repair-deficient human cancers toward a new concept of target genes for instability Cancer Res 62 2002 2447 2454
75. S.M. Woerner, J. Gebert, Y.P. Yuan, C. Sutter, R. Ridder, P. Bork, M. von Knebel Doeberitz Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cells Int J Cancer 93 2001 12 19
76. B. Jung, R.T. Doctolero, A. Tajima, A.K. Nguyen, T. Keku, R.S. Sandler, J.M. Carethers Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers Gastroenterology 126 2004 654 659
77. K. Schulmann, F.E. Brasch, E. Kunstmann, C. Engel, C. Pagenstecher, H. Vogelsang, S. Kruger, T. Vogel, H.P. Knaebel, J. Ruschoff, S.A. Hahn, M.V. Knebel-Doeberitz, G. Moeslein, S.J. Meltzer, H.K. Schackert, C. Tympner, E. Mangold, W. Schmiegel The German HNPCC Consortium HNPCC-associated small bowel cancer clinical and molecular characteristics Gastroenterology 128 2005 590 599
78. A. Olaru, Y. Mori, J. Yin, S. Wang, M.C. Kimos, K. Perry, Y. Xu, F. Sato, F.M. Selaru, E. Deacu, A. Sterian, D. Shibata, J.M. Abraham, S.J. Meltzer Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors Lab Invest 83 2003 1867 1871
79. E. Deacu, Y. Mori, F. Sato, J. Yin, A. Olaru, A. Sterian, Y. Xu, S. Wang, K. Schulmann, A. Berki, T. Kan, J.M. Abraham, S.J. Meltzer Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes Cancer Res 64 2004 7690 7696
80. J.P. Terdiman, D.E. Aust, C.G. Chang, R.F. Willenbucher, G.B. Baretton, F.M. Waldman High resolution analysis of chromosome 18 alterations in ulcerative colitis-related colorectal cancer Cancer Genet Cytogenet 136 2002 129 137
81. K.H. Cheng, J.F. Ponte, S. Thiagalingam Elucidation of epigenetic inactivation of SMAD8 in cancer using targeted expressed gene display Cancer Res 64 2004 1639 1646
82. S.H. Kang, Y.J. Bang, Y.H. Im, H.K. Yang, D.A. Lee, H.Y. Lee, H.S. Lee, N.K. Kim, S.J. Kim Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer Oncogene 18 1999 7280 7286
83. M. Pinto, C. Oliveira, L. Cirnes, J. Carlos Machado, M. Ramires, A. Nogueira, F. Carneiro, R. Seruca Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas J Pathol 200 2003 32 38
84. C. Fiocchi Inflammatory bowel disease etiology and pathogenesis Gastroenterology 115 1998 182 205
85. G. Monteleone, A. Kumberova, N.M. Croft, C. McKenzie, H.W. Steer, T.T. MacDonald Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease J Clin Invest 108 2001 601 609
86. R. Gaedigk, A.M. Duncan, I. Miyazaki, B.H. Robinson, H.M. Dosch ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22 Cytogenet Cell Genet 66 1994 274 276
87. I. Miyazaki, R. Gaedigk, M.F. Hui, R.K. Cheung, J. Morkowski, R.V. Rajotte, H.M. Dosch Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes Biochim Biophys Acta 1227 1994 101 104
88. M. Pietropaolo, L. Castano, S. Babu, R. Buelow, Y.L. Kuo, S. Martin, A. Martin, A.C. Powers, M. Prochazka, J. Naggert Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen J Clin Invest 92 1993 359 371
89. R. Gaedigk, W. Karges, M.F. Hui, S.W. Scherer, H.M. Dosch Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity Genomics 38 1996 382 391
90. J.G. Herman, S.B. Baylin Gene silencing in cancer in association with promoter hypermethylation N Engl J Med 349 2003 2042 2054
91. M. Esteller Relevance of DNA methylation in the management of cancer Lancet Oncol 4 2003 351 358
92. P.A. Jones Epigenetics in carcinogenesis and cancer prevention Ann N Y Acad Sci 983 2003 213 219
93. J.P. Issa, Y.L. Ottaviano, P. Celano, S.R. Hamilton, N.E. Davidson, S.B. Baylin Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon Nat Genet 7 1994 536 540
94. J.P. Issa, P.M. Vertino, C.D. Boehm, I.F. Newsham, S.B. Baylin Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis Proc Natl Acad Sci 93 1996 11757 11762
95. J.P. Issa Aging, DNA methylation and cancer Crit Rev Oncol Hematol 32 1999 31 43
96. J.P. Issa, N. Ahuja, M. Toyota, M.P. Bronner, T.A. Brentnall Accelerated age-related CpG island methylation in ulcerative colitis Cancer Res 61 2001 3573 3577
97. M. Esteller, R. Levine, S.B. Baylin, L.H. Ellenson, J.G. Herman MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas Oncogene 17 1998 2413 2417
98. J.M. Cunningham, E.R. Christensen, D.J. Tester, C.Y. Kim, P.C. Roche, L.J. Burgart, S.N. Thibodeau Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability Cancer Res 58 1998 3455 3460
99. M.L. Veigl, L. Kasturi, J. Olechnowicz, A.H. Ma, J.D. Lutterbaugh, S. Periyasamy, G.M. Li, J. Drummond, P.L. Modrich, W.D. Sedwick, S.D. Markowitz Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers Proc Natl Acad Sci U S A 95 1998 8698 8702
100. N.A. Yamada, R.A. Farber Induction of a low level of microsatellite instability by overexpression of DNA polymerase beta Cancer Res 62 2002 6061 6064
101. J.M. Cunningham, C.Y. Kim, E.R. Christensen, D.J. Tester, Y. Parc, L.J. Burgart, K.C. Halling, S.K. McDonnell, D.J. Schaid, C. Walsh Vockley, V. Kubly, H. Nelson, V.V. Michels, S.N. Thibodeau The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas Am J Hum Genet 69 2001 780 790
102. K. Schulmann, A. Sterian, A. Berki, J. Yin, F. Sato, Y. Xu, A. Olaru, S. Wang, Y. Mori, E. Deacu, J. Hamilton, T. Kan, M.J. Krasna, D.G. Beer, M.S. Pepe, J.M. Abraham, Z. Feng, W. Schmiegel, B.D. Greenwald, S.J. Meltzer Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk Oncogene 2005 April 11[Epub ahead of print]. doi: 10.1038/sj.onc.1208598