메뉴 건너뛰기




Volumn 983, Issue , 2003, Pages 213-219

Epigenetics in carcinogenesis and cancer prevention

Author keywords

5 Methylcytosine; Carcinogenesis; CpG island; Epigenetics

Indexed keywords

ANIMAL CELL; CANCER PREVENTION; CARCINOGENESIS; CELL DIVISION; CONFERENCE PAPER; CPG ISLAND; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SILENCING; GENETIC ANALYSIS; GENETIC PREDISPOSITION; GROWTH INHIBITION; MAMMAL CELL; METHYLATION; NONHUMAN;

EID: 0037356316     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb05976.x     Document Type: Conference Paper
Times cited : (84)

References (40)
  • 1
    • 0027689976 scopus 로고
    • Dynamics of DNA methylation during development
    • BRANDEIS, M., M. ARIEL & H. CEDAR. 1993. Dynamics of DNA methylation during development. Bioessays 15: 709-713.
    • (1993) Bioessays , vol.15 , pp. 709-713
    • Brandeis, M.1    Ariel, M.2    Cedar, H.3
  • 2
    • 0025716275 scopus 로고
    • Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting
    • MONK, M. 1990. Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting. Philos. Trans. R. Soc. Lond. B Biol. Sci. 326: 299-312.
    • (1990) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.326 , pp. 299-312
    • Monk, M.1
  • 3
    • 0031267083 scopus 로고    scopus 로고
    • UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53
    • DROUIN, R. & J.P. THERRIEN. 1997. UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53. Photochem. Photobiol. 66: 719-726.
    • (1997) Photochem. Photobiol. , vol.66 , pp. 719-726
    • Drouin, R.1    Therrien, J.P.2
  • 4
    • 0030840328 scopus 로고    scopus 로고
    • Imprinting of Igf2 and H19 from a 130 kb YAC transgene
    • AINSCOUGH, J.F. et al. 1997. Imprinting of Igf2 and H19 from a 130 kb YAC transgene. Development 124: 3621-3632.
    • (1997) Development , vol.124 , pp. 3621-3632
    • Ainscough, J.F.1
  • 5
    • 0033531134 scopus 로고    scopus 로고
    • The imprinting box of the mouse Igf2r gene
    • BIRGER, Y. et al. 1999. The imprinting box of the mouse Igf2r gene. Nature 397: 84-88.
    • (1999) Nature , vol.397 , pp. 84-88
    • Birger, Y.1
  • 6
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • BESTOR, T.H. 2000. The DNA methyltransferases of mammals. Hum. Mol. Genet. 9: 2395-2402.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 7
    • 0028333951 scopus 로고
    • Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer
    • MAGEWU, A.N. & P.A. JONES. 1994. Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer. Mol. Cell. Biol. 14: 4225-4232.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4225-4232
    • Magewu, A.N.1    Jones, P.A.2
  • 8
    • 0023318626 scopus 로고
    • Non-methylated CpG-rich islands at the human alpha-globin locus: Implications for evolution of the alpha-globin pseudogene
    • BIRD, A.P. et al. 1987. Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene. EMBO J. 6: 999-1004.
    • (1987) EMBO J. , vol.6 , pp. 999-1004
    • Bird, A.P.1
  • 9
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • BIRD, A.P. 1986. CpG-rich islands and the function of DNA methylation. Nature 321: 209-213.
    • (1986) Nature , vol.321 , pp. 209-213
    • Bird, A.P.1
  • 10
    • 0029903164 scopus 로고    scopus 로고
    • DNA-replication fidelity, mismatch repair and genome instability in cancer cells
    • UMAR, A. & T.A. KUNKEL. 1996. DNA-replication fidelity, mismatch repair and genome instability in cancer cells. Eur. J. Biochem. 238: 297-307.
    • (1996) Eur. J. Biochem. , vol.238 , pp. 297-307
    • Umar, A.1    Kunkel, T.A.2
  • 11
    • 0030776227 scopus 로고    scopus 로고
    • Correction of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6
    • UMAR, A. et al. 1997. Correction of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res. 57: 3949-3955.
    • (1997) Cancer Res. , vol.57 , pp. 3949-3955
    • Umar, A.1
  • 12
    • 0031419674 scopus 로고    scopus 로고
    • Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects
    • GLAAB, W.E. & K.R. TINDALL. 1997. Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects. Carcinogenesis 18: 1-8.
    • (1997) Carcinogenesis , vol.18 , pp. 1-8
    • Glaab, W.E.1    Tindall, K.R.2
  • 13
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • HERMAN, J.G. et al. 1998. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA 95: 6870-6875.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6870-6875
    • Herman, J.G.1
  • 14
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • OKANO, M. et al. 1999. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1
  • 15
    • 0032102949 scopus 로고    scopus 로고
    • Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells
    • OKANO, M., S. XIE & E. LI. 1998. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res. 26: 2536-2540.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 2536-2540
    • Okano, M.1    Xie, S.2    Li, E.3
  • 16
    • 0023701018 scopus 로고
    • Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases
    • BESTOR, T. et al. 1988. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J. Mol. Biol. 203: 971-983.
    • (1988) J. Mol. Biol. , vol.203 , pp. 971-983
    • Bestor, T.1
  • 17
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
    • ROBERTSON, K.D. et al. 2000. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat. Genet. 25: 338-342.
    • (2000) Nat. Genet. , vol.25 , pp. 338-342
    • Robertson, K.D.1
  • 18
    • 0035962632 scopus 로고    scopus 로고
    • DNA methylation, chromatin inheritance, and cancer
    • ROUNTREE, M.R. et al. 2001. DNA methylation, chromatin inheritance, and cancer. Oncogene 20: 3156-3165.
    • (2001) Oncogene , vol.20 , pp. 3156-3165
    • Rountree, M.R.1
  • 19
    • 0033515483 scopus 로고    scopus 로고
    • Identification of initiation sites for DNA replication in the human dnmt1 (DNA-methyltransferase) locus
    • ARAUJO, F.D., et al. 1999. Identification of initiation sites for DNA replication in the human dnmt1 (DNA-methyltransferase) locus. J. Biol. Chem. 274: 9335-9341.
    • (1999) J. Biol. Chem. , vol.274 , pp. 9335-9341
    • Araujo, F.D.1
  • 20
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • REIK, W., W. DEAN & J. WALTER. 2001. Epigenetic reprogramming in mammalian development. Science 293: 1089-1093.
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 21
    • 0035510088 scopus 로고    scopus 로고
    • Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer
    • TAKAI, D. et al. 2001. Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer. Hum. Mol. Genet. 10: 2619-2626.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 2619-2626
    • Takai, D.1
  • 23
    • 0034192151 scopus 로고    scopus 로고
    • Quantitative measure of c-ab1 and p15 methylation in chronic myelogenous leukemia: Biological implications
    • NGUYEN, T.T. et al. 2000. Quantitative measure of c-ab1 and p15 methylation in chronic myelogenous leukemia: biological implications. Blood 95: 2990-2992.
    • (2000) Blood , vol.95 , pp. 2990-2992
    • Nguyen, T.T.1
  • 24
    • 0035300727 scopus 로고    scopus 로고
    • Methylation of p15 and p16 genes in acute promyelocytic leukemia: Potential diagnostic and prognostic significance
    • CHIM, C.S. et al. 2001. Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance. J. Clin. Oncol. 19: 2033-2040.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2033-2040
    • Chim, C.S.1
  • 25
    • 0035876192 scopus 로고    scopus 로고
    • Methylation of p15 and p16 genes in adult acute leukemia: Lack of prognostic significance
    • CHIM, C.S. et al. 2001. Methylation of p15 and p16 genes in adult acute leukemia: lack of prognostic significance. Cancer 91: 2222-2229.
    • (2001) Cancer , vol.91 , pp. 2222-2229
    • Chim, C.S.1
  • 26
    • 0035802289 scopus 로고    scopus 로고
    • Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells
    • NGUYEN, C. et al. 2001. Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. J. Natl. Cancer Inst. 93: 1465-1472.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1465-1472
    • Nguyen, C.1
  • 27
    • 0031035406 scopus 로고    scopus 로고
    • Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia
    • BATOVA, A. et al. 1997. Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. Cancer Res. 57: 832-836.
    • (1997) Cancer Res. , vol.57 , pp. 832-836
    • Batova, A.1
  • 28
    • 0032459591 scopus 로고    scopus 로고
    • High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene
    • UCHIDA, T. et al. 1998. High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene. Leuk. Lymphoma 32: 9-18.
    • (1998) Leuk. Lymphoma , vol.32 , pp. 9-18
    • Uchida, T.1
  • 29
    • 0033233233 scopus 로고    scopus 로고
    • P15INK4b gene methylation and myelodysplastic syndromes
    • QUESNEL, B. & P. FENAUX. 1999. P15INK4b gene methylation and myelodysplastic syndromes. Leuk. Lymphoma 35: 437-443.
    • (1999) Leuk. Lymphoma , vol.35 , pp. 437-443
    • Quesnel, B.1    Fenaux, P.2
  • 30
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • GONZALEZ-ZULUETA, M. et al. 1995. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res. 55: 4531-4535.
    • (1995) Cancer Res. , vol.55 , pp. 4531-4535
    • Gonzalez-Zulueta, M.1
  • 31
    • 0343953594 scopus 로고    scopus 로고
    • Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia
    • MYOHANEN, S.K., S.B. BAYLIN & J.G. HERMAN. 1998. Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res. 58: 591-593.
    • (1998) Cancer Res. , vol.58 , pp. 591-593
    • Myohanen, S.K.1    Baylin, S.B.2    Herman, J.G.3
  • 32
    • 0034745679 scopus 로고    scopus 로고
    • Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer
    • BURRI, N. et al. 2001. Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer. Lab. Invest. 81: 217-229.
    • (2001) Lab. Invest. , vol.81 , pp. 217-229
    • Burri, N.1
  • 33
    • 0031964055 scopus 로고    scopus 로고
    • Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines
    • BENDER, C.M., M.M. PAO & P.A. JONES. 1998. Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res. 58: 95-101.
    • (1998) Cancer Res. , vol.58 , pp. 95-101
    • Bender, C.M.1    Pao, M.M.2    Jones, P.A.3
  • 34
    • 0032827113 scopus 로고    scopus 로고
    • Roles of cell division and gene transcription in the methylation of CpG islands
    • BENDER, C.M. et al. 1999. Roles of cell division and gene transcription in the methylation of CpG islands. Mol. Cell. Biol. 19: 6690-6698.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6690-6698
    • Bender, C.M.1
  • 35
    • 0022613502 scopus 로고
    • Alterations in the X chromosome replication pattern induced by 5-azacytidine in a human tumor line
    • GREGORY, P. & N. WANG. 1986. Alterations in the X chromosome replication pattern induced by 5-azacytidine in a human tumor line. Cancer Genet. Cytogenet. 20: 263-267.
    • (1986) Cancer Genet. Cytogenet. , vol.20 , pp. 263-267
    • Gregory, P.1    Wang, N.2
  • 36
    • 0036135014 scopus 로고    scopus 로고
    • Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
    • LIANG, G. et al. 2002. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol. Cell. Biol. 22: 480-491.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 480-491
    • Liang, G.1
  • 37
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • GREENBLATT, M.S. et al. 1994. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54: 4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1
  • 38
    • 0026362340 scopus 로고
    • 5-Methylcytosine as an endogenous mutagen in the p53 tumor suppressor gene
    • RIDEOUT, W.M., 3rd et al. 1991. 5-Methylcytosine as an endogenous mutagen in the p53 tumor suppressor gene. Princess Takamatsu Symp. 22: 207-219.
    • (1991) Princess Takamatsu Symp. , vol.22 , pp. 207-219
    • Rideout W.M. III1
  • 39
    • 0021191388 scopus 로고
    • Impaired enzymatic methylation of BPDE-modified DNA
    • PFEIFER, G.P., D. GRUNBERGER & D. DRAHOVSKY. 1984. Impaired enzymatic methylation of BPDE-modified DNA. Carcinogenesis 5: 931-935.
    • (1984) Carcinogenesis , vol.5 , pp. 931-935
    • Pfeifer, G.P.1    Grunberger, D.2    Drahovsky, D.3
  • 40
    • 0034732883 scopus 로고    scopus 로고
    • p53 mutational spectra and the role of methylated CpG sequences
    • PFEIFER, G.P. 2000. p53 mutational spectra and the role of methylated CpG sequences. Mutat. Res. 450: 155-166.
    • (2000) Mutat. Res. , vol.450 , pp. 155-166
    • Pfeifer, G.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.