DPC4 gene mutation in colitis associated neoplasia

Gut

Volumn 40, Issue 1, 1997, Pages 120-122

  Hoque, A T M S ^a   Hahn, S A ^a   Schutte, M ^a   Kern, S E ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

In vitro synthesis; In vitro synthesised protein assay; LOH; Loss of heterozygosity

Indexed keywords

ADULT; AGED; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; COLITIS; GENE LOCATION; GENE MUTATION; HUMAN; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0031057713     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.40.1.120     Document Type: Article

References (13)

1. Kern SE, Redston M, Caldas C, Seymour A, Kornacki S, Powell SM, et al. Molecular genetic profiles of colitis-associated neoplasms. Gastroenterology 1994; 107: 420-8.
2. Redston MS, Papadopoulos N, Caldas C, Kinzler KW, Kern SE. Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias. Gastroenterology 1995; 108: 383-92.
3. Burmer GC, Levine DS, Kulander BG, Haggitt RC, Rubin CE, Rabinovitch PS. c-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma. Gastroenterology 1990; 99: 416-20.
4. Meltzer SJ, Mane SM, Wood PK, Resau JH, Newkirk C, Terzakis JA, et al. Activation of c-Ki-ras in human gastrointestinal dysplasias determined by direct sequencing of polymerase chain reaction products. Cancer Res 1990; 50: 3627-30.
5. Bell SM, Kelly SA, Hoyle JA, Lewis FA, Taylor GR, Thompson H, et al. c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis. Br J Cancer 1991; 64: 174-8.
6. Chen J, Compton C, Cheng E, Fromowitz F, Viola MV. c-Ki-ras mutations in dysplastic fields and cancers in ulcerative colitis. Gastroenterology 1992; 102: 1983-7.
7. Burmer GC, Rabinovitch PS, Haggitt RC, Crispin DA, Brentnall TA, Kolli VR, et al. Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele. Gastroenterology 1992; 103: 1602-10.
8. Yin J, Harpaz N, Tong Y, Huang Y, Laurin J, Greenwald BD, et al. p53 point mutations in dysplastic and cancerous ulcerative colitis lesions. Gastroenterology 1993; 104: 1635-9.
9. Hahn SA, Seymour AB, Hoque ATMS, Schutte M, da Costa LT, Redston MS, et al. Allelotype of pancreatic adenocarcinoma using a xenograft model. Cancer Res 1995; 55: 4670-5.
10. Hahn SA, Schutte M, Hoque ATMS, Moskaluk CA, da Costa LT, Rozenblum E, et al. DPC4, a candidate tumor-suppressor gene at 18q21·1. Science 1996; 271: 350-3.
11. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990; 247: 49-56.
12. Cairns P, Polascik TJ, Eby Y, Tokino K, Califano J, Merlo A, et al. Frequency of homozygous deletion at p16/CDKN2 in primary human tumors. Nature Genet 1995; 11: 210-2.
13. Powell SM, Petersen GM, Krush AJ, Booker S, Jen J, Giardiello FM, et al. Molecular diagnosis of familial adenomatous polyposis. N Engl J Med 1993; 329: 1982-7.