Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-β response pathway genes

Cancer Research

Volumn 64, Issue 21, 2004, Pages 7690-7696

  Deacu, Elena ^a   Mori, Yuriko ^a   Sato, Fumiaki ^b   Yin, Jing ^a   Olaru, Andreea ^a   Sterian, Anca ^a   Xu, Yan ^a   Wang, Suna ^a   Schulmann, Karsten ^a   Berki, Agnes ^a   Kan, Takatsugu ^a   Abraham, John M ^a   Meltzer, Stephen J ^a,b  

^a BALTIMORE VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR 2; GUANOSINE TRIPHOSPHATASE; PROTEIN FOS; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CANCER CELL CULTURE; CELL DISRUPTION; CELL GROWTH; COLON CARCINOMA; DNA MICROARRAY; FRAMESHIFT MUTATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UNINDEXED SEQUENCE; WESTERN BLOTTING; WILD TYPE;

ACTIVIN RECEPTORS, TYPE II; CELL DIVISION; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PHOSPHORYLATION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 7444232278     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2082     Document Type: Article

References (26)

1. Chen YG, Lui HM, Lin SL, Lee JM, Ying SY. Regulation of cell proliferation, apoptosis, and carcinogenesis by activin. Exp Biol Med (Maywood) 2002;227:75-87.
2. Mori Y, Sato F, Selaru FM, et al. Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. Cancer Res 2002;62:3641-5.
3. Hempen PM, Zhang L, Bansal RK, et al. Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers. Cancer Res 2003;63:994-9.
4. Jung B, Doctolero RT, Tajima A, et al. Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Gastroenterology 2004;126:654-9.
5. Eppert K, Scherer SW, Ozcelik H, et al. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 1996;86:543-52.
6. Lagna G, Hata A, Hemmati-Brivanlou A, Massague J. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature (Lond) 1996;383:832-6.
7. Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (Wash DC) 1996;271:350-3.
8. Su GH, Bansal R, Murphy KM, et al. ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. Proc Natl Acad Sci USA 2001;98:3254-7.
9. Zhu Y, Richardson JA, Parada LF, Graff JM. Smad3 mutant mice develop metastatic colorectal cancer. Cell 1998;94:703-14.
10. Liu F, Shao LE, Yu J. Truncated activin type II receptor inhibits erythroid differentiation in K562 cells. J Cell Biochem 2000;78:24-33.
11. Jung B, Beck S, Fiorino A, et al. Functional correlation of growth suppression with activin treatment in microsatellite unstable, activin type 2 receptor (ACVR2)-restored colorectal cancer cells. Gastroenterology 2004;126:A264.
12. Perucho M. Cancer of the microsatellite mutator phenotype. Biol Chem 1996;377:675-84.
13. Markowitz S, Wang J, Myeroff L, et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (Wash DC) 1995;268:1336-8.
14. Ilyas M, Efstathiou JA, Straub J, Kim HC, Bodmer WF. Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression. Proc Natl Acad Sci USA 1999;96:3087-91.
15. Mori Y, Selaru FM, Sato F, et al. The impact of microsatellite instability on the molecular phenotype of colorectal tumors. Cancer Res 2003;63:4577-82.
16. Verrecchia F, Chu ML, Mauviel A. Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 2001;276:17058-62.
17. Zavadil J, Bitzer M, Liang D, et al. Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc Natl Acad Sci USA 2001;98:6686-91.
18. Xie L, Law BK, Aakre ME, et al. Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Res 2003;5:R187-98.
19. Ryu B, Kern SE. The essential similarity of TGFbeta and activin receptor transcriptional responses in cancer cells. Cancer Biol Ther 2003;2:164-70.
20. Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature (Lond) 1998;394:909-13.
21. Li L, Liu L, Rao JN, et al. JunD stabilization results in inhibition of normal intestinal epithelial cell growth through P21 after polyamine depletion. Gastroenterology 2002;123:764-79.
22. Du W, Prendergast GC. Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors. Cancer Res 1999;59:5492-6.
23. Kang Y, Chen CR, Massague J. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 2003;11:915-26.
24. Boulton TG, Nye SH, Robbins DJ, et al. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 1991;65:663-75.
25. Komada M, Kitamura N. Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol Cell Biol 1995;15:6213-21.
26. Perou CM, Jeffrey SS, van de Rijn M, et al. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci USA 1999;96:9212-7.