Differentiation- and maturation-dependent content, localization, and secretion of cystatin C in human dendritic cells

Journal of Leukocyte Biology

Volumn 78, Issue 1, 2005, Pages 122-134

  Zavašnik Bergant, Tina ^a   Repnik, Urška ^b   Schweiger, Ana ^a   Romih, Rok ^c   Jeras, Matjaž ^b   Turk, Vito ^a   Kos, Janko ^c  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b BLOOD TRANSFUSION CENTRE OF SLOVENIA   (Slovenia)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Cathepsins; Human APC; Lymph node; Protease inhibitor; TNF

Indexed keywords

B7 ANTIGEN; CATHEPSIN; CATHEPSIN H; CATHEPSIN L; CATHEPSIN S; CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CYSTATIN C; CYSTEINE PROTEINASE; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY LABELING; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; DENDRITIC CELL; EXOCYTOSIS; GOLGI COMPLEX; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR TRANSPORT; LEUKOCYTE MIGRATION; LYMPH NODE; MONOCYTE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TRANSPORT; T LYMPHOCYTE;

ANTIGEN PRESENTATION; ANTIGENS, SURFACE; BIOLOGICAL MARKERS; CATHEPSINS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CYSTATINS; DENDRITIC CELLS; EXOCYTOSIS; GOLGI APPARATUS; HUMANS; IMMUNITY, CELLULAR; IMMUNOLOGIC FACTORS; INTERLEUKIN-4; LYMPH NODES; MONOCYTES; PROTEIN TRANSPORT; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 22144469068     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0804451     Document Type: Article

References (41)

1. Villadangos, J. A., Ploegh, H. L. (2000) Proteolysis in MHC class II antigen presentation: who is in charge? Immunity 12, 233-239.
2. Riese, R. J., Wolf, P. R., Brömme, D., Natkin, L. R., Villadangos, J. A., Ploegh, H. L., Chapman, H. A. (1996) Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity 4, 357-366.
3. Pierre, P., Mellman, I. (1998) Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. Cell 93, 1135-1145.
4. Villadangos, J. A., Cardoso, M., Steptoe, R. J., van Berkel, D., Pooley, J., Carbone, F. R., Shortman, K. (2001) MHC class II expression is regulated in dendritic cells independently of invariant chain degradation. Immunity 14, 739-749.
5. El-Sukkari, D., Wilson, N. S., Hakansson, K., Steptoe, R. J., Grubb, A., Shortman, K., Villadangos, J. A. (2003) The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation. J. Immunol. 171, 5003-5011.
6. Cella, M., Engering, A., Pinet, V., Pieters, J., Lanzavecchia, A. (1997) Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature 388, 782-787.
7. Pierre, P., Turley, S. J., Gatti, E., Hull, M., Meltzer, J., Mirza, A., Inaba, K., Steinman, R. M., Mellman, T. (1997) Developmental regulation of MHC II class II transport in mouse dendritic cells. Nature, 388, 724-725.
8. Vray, B., Hartmann, S., Hoebeke, J. (2002) Immunomodulatory properties of cystatins. Cell. Mol. Life Sci. 59, 1503-1512.
9. Greiner, A., Lautwein, A., Overkleeft, H. S., Weber, E., Driessen, C. (2003) Activity and subcellular distribution of cathepsins in primary human monocytes. J. Leukoc. Biol. 73, 235-242.
10. Turk, B., Turk, D., Turk, V. (2000) Lysosomal cysteine proteases: more than scavenger. Biochim. Biophys. Acta 1477, 98-111.
11. Bode, W., Engh, R., Musil, D., Thiele, U., Huber, R., Karshikov, A., Brzin, J., Kos, J., Turk, V. (1988) The 2.0 angstroms X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases. EMBO J. 7, 2593-2599.
12. Lautwein, A., Burster, T., Lennon-Duménil, A-M., Overkleeft, H. S., Weber, E., Kalbacher, H., Driessen, C. (2002) Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells. Eur. J. Immunol. 32, 3348-3357.
13. Fiebiger, E., Meraner, P., Weber, E., Fang, I-F., Stingl, G., Ploegh, H., Maurer, D. (2001) Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells. J. Exp. Med. 193, 881-892.
14. Hashimoto, S., Suzuki, T., Nagai, S., Yamashita, T., Toyoda, N., Matsushima, K. (2000) Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression. Blood 96, 2206-2214.
15. Kos, J., Krašovec, M., Cimerman, N., Nielsen, H. J., Christensen, I. J., Brünner, N. (2000) Cysteine proteinase inhibitors stefin A. stefin B and cystatin C in sera from patients with colorectal cancer: relation to prognosis. Clin. Cancer Res. 6, 505-511.
16. Kos, J., Sekirnik, A., Kopitar, G., Cimerman, N., Kayser, K., Stremmer, A., Fiehn, W., Werle, B. (2001) Cathepsin S in tumors, regional lymph nodes and sera of patients with lung cancer: relation to prognosis. Br. J. Cancer 85, 1193-1200.
17. Schweiger, A., Štabuc, B., Popović, T., Turk, V., Kos, J. (1997) Enzyme-linked immunosorbent assay for the detection of total cathepsin H in human tissue cytosols and sera. J. Immunol. Methods 201, 165-172.
18. Kos, J., Štabuc, B., Schweiger, A., Krašovec, M., Kopitar-Jerala, N., Vrhovec, I. (1997) Cathepsins B, H and L and their inhibitors stefin A and cystatin C in sera of melanoma patients. Clin. Cancer Res. 3, 1815-1822.
19. Grujić, M., Renko, M. (2002) Aminopeptidase inhibitors bestatin and actinonin inhibit cell proliferation of myeloma cells predominantly by intracellular interactions. Cancer Lett. 182, 113-119.
20. Repnik, U., Knezevic, M., Jeras, M. (2003) Simple and cost-effective isolation of monocytes from buffy coats. J. Immunol. Methods 278, 283-292.
21. Zavašnik-Bergant, V., Sekirnik, A., Golouh, R., Turk, V., Kos, J. (2001) Immunochemical localization of cathepsin S. cathepsin L and MHC class II-associated p41 isoform of invariant chain in human lymph node tissue. Biol. Chem. 382, 799-804.
22. Strojnik, T., Kos, J., Židanik, B., Golouh, R., Lah, T. (1999) Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors. Clin. Cancer Res. 5, 559-567.
23. Zavašnik-Bergant, V., Schweiger, A., Bevec, T., Colouh, R., Turk, V., Kos, J. (2004) Inhibitory p41 isoform of invariant chain and its potential target enzymes cathepsins L and H in distinct imputations of macrophages in human lymph nodes. Immunology 112, 378-385.
24. Yoshino, A., Bieler, B. M., Harper, D., Cowan, C., Sutterwala, D. A., Gay, S., Cole, D. M., Mc, N. B., Caffery, J. M., Marks, M. S. (2003) A role for GRIP domain proteins and/or their ligands in structure and function of the trans Golgi network. J. Cell Sci. 116, 4441-4454.
25. Brömme, D., Rinne, R., Kirschke, H. (1991) Tight-binding inhibition of cathepsin S by cystatins. Biomed. Biochim. Acta 50, 631-635.
26. Popović, T., Brzin, J., Ritonja, A., Turk, V. (1990) Different forms of human cystatin C. Biol. Chem. Hoppe Seyler 371, 575-580.
27. Lennon-Duménil, A-M., Bakker, A. H., Machr, R., Fiebiger, E., Overkleeft, H. S., Rosemblatt, M., Ploegh, H. L., Lagaudriére-Cesbert, C. (2002) Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic content during dendritic cell activation. J. Exp. Med. 196, 529-539.
28. Nakagawa, T. Y., Brissette, W. H., Lira, P. D., Griffiths, R. J., Petrushova, N., Stock, J., McNeish, J. D., Eastman, S., Howard, E. D., Clarke, S. R. M., Rosloniec, E. F., Elliot, E., A., Rudensky, A. Y. (1999) Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity 10, 207-217.
29. Plüger, E. B., Boes, M., Alfonso, C., Schröter, C. J., Kalbacher, H., Ploegh, H. L., Driessen, C. (2002) Specific role for cathepsin S in the generation of antigenic peptides in vivo. Eur. J. Immunol. 32, 467-476.
30. Hsieh, C-S., deRoos, P., Honey, K., Beers, C., Rudensky, A. Y. (2002) A role of cathepsin L and cathepsin S in peptide generation for MHC class II presentation. J. Immunol. 165, 2618-2625.
31. Bender, A., Sapp, M., Schuler, C., Steinman, R. M., Bhardwaj, N. (1996) Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J. Immunol. Methods 196, 121-135.
32. Thurner, B., Röder, C., Dieckmann, D., Heuer, M., Krause, M., Glaser, A., Keikavoussi, P., Kämpgen, E., Bender, A., Schuler, G. (1999) Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J. Immunol. Methods 223, 1-15.
33. Sallusto, F., Cella, M., Danieli, C., Lanzavecchia, A. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389-400.
34. Steinman, R. M., Pack, M., Inaba, K. (1997) Dendritic cells in T-cell areas of lymphoid organs. Immunol. Rev. 156, 25-37.
35. Nishikawa, S., Sasaki, F. (2000) Detection of immature dendritic cells in the enamel organ of rat incisors by using anti-cystatin C and anti-MHC class II immunocytochemistry. J. Histochem. Cytochem. 48, 1243-1255.
36. Punturiere, A., Filippov, S., Allen, E., Caras, I., Murray, R., Reddy, V., Weiss, S. J. (2000) Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages. J. Exp. Med. 192, 789-799.
37. Chapman, H. A. (1991) Role of enzyme receptors and inhibitors in regulating proteolytic activities of macrophages. Ann. N. Y. Acad. Sci. 624, 87-96.
38. Tew, J. G., Wu, J., Qin, D., Helm, S., Burton, G. F., Szakal, A. K. (1997) Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells. Immunol. Rev. 156, 39-52.
39. Allavena, P., Sica, A., Vecchi, A., Locati, M., Sozzani, S., Mantovani, A. (2000) The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues. Immunol. Rev. 177, 141-149.
40. Bieth, J. G. (1984) In vivo significance of kinetic constants of protein proteinase inhibitors. Biochem. Med. 32, 387-397.
41. Fiebiger, E., Maehr, R., Villadangos, J., Weber, E., Erickson, A., Bikoff, E., Ploegh, H. L., Lennon-Duménil, A-M. (2002) Invariant chain controls the activity of extracellular cathepsin L. J. Exp. Med. 196, 1263-1269.