Invariant chain controls the activity of extracellular cathepsin L

Journal of Experimental Medicine

Volumn 196, Issue 9, 2002, Pages 1263-1269

  Fiebiger, Edda ^a   Maehr, René ^a   Villadangos, José ^b   Weber, Ekkehard ^c   Erickson, Ann ^d   Bikoff, Elizabeth ^e   Ploegh, Hidde L ^a   Lennon Duménil, Ana Maria ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

Antigen presenting cells; Extracellular matrix degradation; Invariant chain; Protease; Secretion

Indexed keywords

CATHEPSIN L; PROTEINASE; RECOMBINANT GAMMA INTERFERON; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW CELL; DENDRITIC CELL; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALTERNATIVE SPLICING; ANIMALS; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CATHEPSINS; CELLS, CULTURED; CULTURE MEDIA; CYSTEINE ENDOPEPTIDASES; DENDRITIC CELLS; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; UP-REGULATION;

EID: 0037020835     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020762     Document Type: Article

References (29)

1. Bryant, P.W., A.M. Lennon-Dumenil, E. Fiebiger, C. Lagaudriere-Gesbert, and H.L. Ploegh. 2002. Proteolysis and antigen presentation by MHC class II molecules. Adv. Immunol. 80:71-114.
2. Lennon-Dumenil, A.M., A.H. Bakker, P. Wolf-Bryant, H.L. Ploegh, and C. Lagaudriere-Gesbert. 2002. A closer look at proteolysis and MHC-class-II-restricted antigen presentation. Curr. Opin. Immunol. 14:15-21.
3. McGrath, M.E. 1999. The lysosomal cysteine proteases. Annu. Rev. Biophys. Biomol. Struct. 28:181-204.
4. Carmeliet, P., L. Moons, R. Lijnen, M. Baes, V. Lemaitre, P. Tipping, A. Drew, Y. Eeckhout, S. Shapiro, F. Lupu, and D. Collen. 1997. Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nat. Genet. 17:439-444.
5. Chapman, H.A., R.J. Riese, and G.P. Shi. 1997. Emerging roles for cysteine proteases in human biology. Annu. Rev. Physiol. 59:63-88.
6. Erickson, A.H. 1989. Biosynthesis of lysosomal endopeptidases. J. Cell. Biochem. 40:31-41.
7. Villadangos, J.A., and H.L. Ploegh. 2000. Proteolysis in MHC class II antigen presentation: Who's in charge? Immunity. 12:233-239.
8. Chapman, H.A. 1998. Endosomal proteolysis and MHC class II function. Curr. Opin. Immunol. 10:93-102.
9. Bromme, D., A. Steinert, S. Friebe, S. Fittkau, B. Wiederanders, and H. Kirschke. 1989. The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B. Biochem. J. 264:475-481.
10. Shi, G.P., J.S. Munger, J.P. Meara, D.H. Rich, and H.A. Chapman. 1992. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. J. Biol. Chem. 267:7258-7262.
11. Reddy, V.Y., Q.Y. Zhang, and S.J. Weiss. 1995. Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages. Proc. Natl. Acad. Sci. USA. 92:3849-3853.
12. Coulombe, R., P. Grochulski, J. Sivaraman, R. Menard, J.S. Mort, and M. Cygler. 1996. Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. EMBO J. 15:5492-5503.
13. Lennon-Dumenil, A.M., R.A. Roberts, K. Valentijn, C. Driessen, H.S. Overkleeft, A. Erickson, P.J. Peters, E. Bikoff, H.L. Ploegh, and P. Wolf Bryant. 2001. The p41 isoform of invariant chain is a chaperone for cathepsin L. EMBO J. 20: 4055-4064.
14. Strubin, M., C. Berte, and B. Mach. 1986. Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain. EMBO J. 5:3483-3488.
15. Koch, N. 1988. Posttranslational modifications of the Ia-associated invariant protein p41 after gene transfer. Biochemistry. 27:4097-4102.
16. Takaesu, N.T., J.A. Lower, E.J. Robertson, and E.K. Bikoff. 1995. Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain. Immunity. 3:385-396.
17. Takaesu, N.T., J.A. Lower, D. Yelon, E.J. Robertson, and E.K. Bikoff. 1997. In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain. J. Immunol. 158:187-199.
18. Kampgen, E., N. Koch, F. Koch, P. Stoger, C. Heufler, G. Schuler, and N. Romani. 1991. Class II major histocompatibility complex molecules of murine dendritic cells: Synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc. Natl. Acad. Sci. USA. 88:3014-3018.
19. Pierre, P., and I. MeUman. 1998. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. Cell. 93:1135-1145.
20. Ogrinc, T., I. Dolenc, A. Ritonja, and V. Turk. 1993. Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney. FEBS Lett. 336:555-559.
21. Guncar, G., G. Pungercic, I. Klemencic, V. Turk, and D. Turk. 1999. Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S. EMBO J. 18: 793-803.
22. Punturieri, A., S. Filippov, E. Allen, I. Caras, R. Murray, V. Reddy, and S.J. Weiss. 2000. Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages. J. Exp. Med. 192:789-799.
23. Nakagawa, T., W. Roth, P. Wong, A. Nelson, A. Farr, J. Deussing, J.A. Villadangos, H. Ploegh, C. Peters, and A.Y. Rudensky. 1998. Cathepsin L: Critical role in Ii degradation and CD4 T cell selection in the thymus. Science. 280:450-453.
24. Bogyo, M., S. Verhelst, V. Bellingard-Dubouchaud, S. Toba, and D. Greenbaum. 2000. Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. Chem. Biol. 7:27-38.
25. Greenbaum, D., K.F. Medzihradszky, A. Burlingame, and M. Bogyo. 2000. Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chem. Biol. 7:569-581.
26. Liotta, L.A., P.S. Steeg, and W.G. Stetler-Stevenson. 1991. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell. 64:327-336.
27. Felbor, U., L. Dreier, R.A. Bryant, H.L. Ploegh, B.R. Olsen, and W. Mothes. 2000. Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J. 19:1187-1194.
28. Ishigami, S., S. Natsugoe, K. Tokuda, A. Nakajo, H. Iwashige, K. Aridome, S. Hokita, and T. Aikou. 2001. Invariant chain expression in gastric cancer. Cancer Lett. 168:87-91.
29. Stevens, T.H., and M. Forgac. 1997. Structure, function and regulation of the vacuolar (H+)-ATPase. Annu. Rev. Cell Dev. Biol. 13:779-808.