Transcriptional targeting of acute hypoxia in the tumour stroma is a novel and viable strategy for cancer gene therapy

Gene Therapy

Volumn 12, Issue 13, 2005, Pages 1058-1069

  Ingram, N ^a,b   Porter, C D ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Cancer gene therapy; Hypoxia; Retrovirus; Transcriptional targeting; Tumour stroma

Indexed keywords

GANCICLOVIR; RETROVIRUS VECTOR; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER THERAPY; CANCER TISSUE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENHANCER REGION; EXPRESSION VECTOR; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXEMIA; IN VITRO STUDY; LONG TERMINAL REPEAT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; STROMA; TISSUE NECROSIS; TUMOR BLOOD FLOW; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; VASCULAR ENDOTHELIUM;

3T3 CELLS; ANIMALS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC VECTORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MICE; NECROSIS; NEOPLASM TRANSPLANTATION; NEOPLASMS; NUCLEAR PROTEINS; PHOSPHOGLYCERATE KINASE; RESPONSE ELEMENTS; RETROVIRIDAE; TERMINAL REPEAT SEQUENCES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS;

EID: 21744437598     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302504     Document Type: Article

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