Association of a serotonin transporter gene promoter polymorphism with harm avoidance behaviour in an elderly population

Psychiatric Genetics

Volumn 8, Issue 2, 1998, Pages 41-44

  Ricketts, M H ^a   Hamer, R M ^a   Sage, J I ^a   Manowitz, P ^a   Feng, F ^a   Menza, M A ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

5 HTTLPR; Aging; Anxiety; Depression; Parkinson's disease; Personality traits; Temperament genetics; Tridimensional personality questionnaire

Indexed keywords

NUCLEOTIDE; SEROTONIN TRANSPORTER;

ADULT; AGED; ALLELE; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; GENE DELETION; GENE DOSAGE; GENE INSERTION; GENETIC POLYMORPHISM; GENOTYPE; GERONTOPSYCHIATRY; HUMAN; MALE; PARKINSON DISEASE; PERSONALITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; TEMPERAMENT;

EID: 0031853038     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-199800820-00001     Document Type: Article

References (26)

1. Ball D, Hill L, Freeman B, Eley TC, Strelau J, Riemann R, Spinath FM, Angleitner A, Plomin R (1997). The serotonin transporter gene and peer-rated neuroticism. Neuroreport 8:1301-1304.
2. Barden N, Reul JMHM, Holsboer F (1995). Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci 18:6-11.
3. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH (1996). Population and familial association between the D4 dopamine receptor and measures of novelty seeking. Nat Genet 12:81-84.
4. Carroll BJ, Curtis GC, Mendels J (1976). Neuroendocrine regulation in depression: I. Limbic system-adrenocortical dysfunction. Arch Gen Psychiatry 33:1039-1044.
5. Cloninger RC (1986). Unified theory of personality and its role in the development of anxiety states. Psychiatric Developments 3:167-226.
6. Cloninger RC (1987). A systematical method for clinical description and classification of personality variants. Arch Gen Psychiatry 44:573-588.
7. Collier DA, Stober G, Li T, Heils A, Catalano M, Di Bella D et al. (1996). A novel functional polymorphism within the promoter of the serotonin transporter gene - possible role in susceptibility to affective disorders. Molecular Psychiatry 1:453-460.
8. Costa PTJ, McCrae RR (1992). In: Revised NEO Personality Inventory (NEO-PI-R) and NEO Five Inventory (NEO-FFI) Professional Manual. Psychological Assessment Resources, Odessa, FL.
9. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D et al. (1996). Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 12:78-80.
10. Ebstein RP, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker RH (1997). No association between the serotonin transporter gene regulatory region polymorphism and the tridimensional personality questionnaire (TPQ) temperament of harm avoidance. Molecular Psychiatry 2:224-226.
11. Fumagalli F, Jones SR, Caron MG, Seidler FJ, Slotkin TA (1996). Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids. Brain Res 719:225-228.
12. Heath AC, Cloninger CR, Martin NG (1994). Testing a model for the genetic structure of personality: a comparison of the personality systems of Cloninger and Eysenck. J Pers Soc Psychol 66:762-775.
13. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D et al. (1996). Allelic variation of human serotonin gene expression. J Neurochem 66:2621-2624.
14. Heils A, Mössner R, Bengel K, Glatz D, Murohy DL, Lesch KP (1997). Allelic variation of glucocorticosteroid hormone dependent serotonin transporter regulation. Society for Neuroscience Abstracts 23:1239.
15. Kendler KS, Walters EE, Truett KR, Heath AC, Neale MC, Martin NG et al. (1995). A twin-family study of self-report symptoms of panic-phobia and somatization. Behav Genet 25:499-515.
16. Lesch, KP Aulakh CS, Wolozin BL, Tolliver TJ, Hill JL, Murphy DL (1993). Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Brain Res 17:31-35.
17. Lesch KP, Bengal D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
18. Loehlin JC (1989). Partitioning environmental and genetic contributions to behavioral development. Am Psychol 44:1285-1292.
19. Lupien S, Lecours AR, Schwartz G, Sharma S, Hauger RL, Meaney MJ et al. (1996). Longitudinal study of basal cortisol levels in healthy elderly subjects: evidence for subgroups. Neurobiol Aging 17:95-105.
20. Malhotra AK, Virkkunen M, Rooney W, Eggert M, Linnoila M, Goldman D (1996). The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. Molecular Psychiatry 1:388-391.
21. McEwen BS (1992). Re-examination of the glucocorticoid hypothesis of stress and aging. Prog Brain Res 93:365-380.
22. Plomin R, Owen MJ, McGuffin P (1994). The genetic basis of complex human behaviors. Science 264:1733-1739.
23. Sachar EJ, Hellman L, Roffwarg HP, Halpern FS, Fukishima DK, Gallagher TF (1973). Disrupted 24-hour patterns of cortisol secretion in psychotic depression. Arch Gen Psychiatry 28:19-24.
24. Slotkin TA, McCook EC, Ritchie JC, Seidler FJ (1996). Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. Biol Psychiatry 40:576-584.
25. Slotkin TA, McCook EC, Ritchie JC, Carroll BJ, Seidler FJ (1997). Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. Biol Psychiatry 41:172-183.
26. Young EA, Haskett RF, Murphy-Weinberg V, Watson SJ, Akil H (1991). Loss of glucocorticoid fast feedback in depression. Arch Gen Psychiatry 48:693-699.