Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese

Journal of Human Genetics

Volumn 44, Issue 1, 1999, Pages 15-17

  Murakami, Fumiyo ^a   Shimomura, Tokio ^a   Kotani, Kazuhiko ^b   Ikawa, Shiro ^a   Nanba, Eiji ^c   Adachi, Kaori ^c  

^a TOTTORI UNIVERSITY   (Japan)

^b Department of Internal Medicine   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

Anxiety traits; Frequency distribution; Healthy Japanese; Serotonin transporter gene linked poly region (5 HTTLPR); SRQ AD

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; AGED; ANXIETY; ARTICLE; DEPRESSION; DNA DETERMINATION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SCREENING; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; JAPAN; MALE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; POPULATION RISK; REGULATOR GENE; SCORING SYSTEM; SELF CONCEPT; SEROTONIN RELEASE;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ANXIETY; ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; CARRIER PROTEINS; DNA PRIMERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; HUMANS; JAPAN; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0032961483     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380050098     Document Type: Article

References (9)

1. 3H-paroxetine binding sites in rat brain. J Pharmacol Toxicol Methods 27: 209-216
2. El-Rufaie OEF, Absood GH, Abou-Saleh MT (1997) The primary care anxiety and depression (PCAD) scale: A culture-oriented screening scale. Acta Psychiatr Scand 95: 119-124
3. Heils A, Teufel A, Petri S, Seemann M, Bengle D, Balling U, Riederer P, Lesch KP (1995) Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm Gen Sect 102: 247-254
4. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66: 2621-2624
5. Hensler JG, Ferry RC, Labow DM, Kovachich GB, Frazer A (1994) Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus. Synapse 17: 1-15
6. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P (1994) Organization of human serotonin transporter gene. J Neural Transm Gen Sect 95: 157-164
7. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531
8. Ogilvie AO, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, Smith CAD (1996) Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347: 731-733
9. Tsutsui S (1981) Clinical study on depression in the field of internal medicine (in Japanese). J Med Soc Toho Japan 28: 1-6