No association between serotonin transporter gene polymorphisms and personality traits

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 88, Issue 4, 1999, Pages 430-436

  Gustavsson, J Petter ^a,b   Nöthen, Markus M ^c   Jönsson, Erik G ^a   Neidt, Helge ^c   Forslund, Kaj ^a   Rylander, Gunnar ^a   Mattila Evenden, Marja ^a   Sedvall, Göran C ^a   Propping, Peter ^c   Åsberg, Marie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF SKÖVDE   (Sweden)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Association study; Genetics; Karolinska Scales of Personality (KSP); Neuroticism; Polymorphism; Promoter; Serotonin transporter; Trait anxiety

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; AGED; ARTICLE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PERSONALITY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; SWEDEN;

ADULT; AGED; ALLELES; CARRIER PROTEINS; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROTIC DISORDERS; PERSONALITY; POLYMORPHISM, GENETIC; QUESTIONNAIRES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0033588256     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19990820)88:4<430::AID-AJMG23>3.0.CO;2-1     Document Type: Article

References (32)

1. Battersby S, Ogilvie AD, Smith CAD, Blackwood DHR, Muir WJ, Quinn JP, Fink G, Goodwin GM, Harmar AJ. 1996. Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder. Psychiatr Genet 6:177-181.
2. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. 1996. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nature Genet 12:81-84.
3. Bertilsson L, Aim C, De Las Carreras C, Widén J, Edman G, Schalling D. 1989. Debrisoquine hydroxylation polymorphism and personality. Lancet 1:555.
4. Brown SL, Svrakic DM, Przybeck TR, Cloninger DR. 1992. The relationship of personality to mood and anxiety states: a dimensional approach. J Psychiatr Res 26:197-211.
5. Cloninger CR. 1986. A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr Dev 3:167-226.
6. Cloninger CR. 1987. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 44: 573-588.
7. Cloninger CR, Svrakic DM, Przybeck TR. 1993. A psychobiological model of temperament and character. Arch Gen Psychiatry 50:975-990.
8. Cloninger CR, Van Eerdewegh P, Goate A, Edenberg HJ, Blangero J, Hesselbrock V, Reich T, Nurnberger J Jr, Schuckit M, Porjesz B, Crowe R, Rice JP, Foroud T, Przybeck TR, Almasy L, Bucholz K, Wu W, Shears S, Carr K, Crose C, Willig C, Zhao J, Tischfield JA, Li TK, Conneally PM, Begleiter H. 1998. Anxiety proneness linked to epistatic loci in genome scan of human personality traits. Am J Med Genet 81:313-317.
9. Costa PT Jr, McCrae RR. 1992. Four ways five factors are basic. Pers Individ Diff 13:653-665.
10. Eaves L, Eysenck HJ, Martin NG. 1989. Genes, culture and personality: an empirical approach. London: Academic Press.
11. Ebstein RP, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker RH. 1997a. No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoidance. Mol Psychiatry 2: 224-226.
12. Ebstein RP, Levine J, Geller V, Auerbach J, Gritsenko I, Belmaker RH. 1998. Dopamine D4 receptor and serotonin transporter promoter in the determination of neonatal temperament. Mol Psychiatry 3:238-246.
13. Ebstein RP, Nemanov L, Klotz I, Gritsenko I, Belmaker RH. 1997b. Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of novelty seeking. Mol Psychiatry 2:472-477.
14. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bennet ER, Nemanov L, Katz M, Belmaker RH. 1996. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nature Genet 12:78-80.
15. Ekselius L, von Knorring L. 1997. Changes in personality during treatment with serfraline and citalopram. Proceedings from the 5th International Congress on the Personality. Vancouver: University of British Columbia, p 46-47.
16. Farde L, Gustavsson JP, Jösson E. 1997. D2 dopamine receptors and personality traits. Nature 385:590.
17. Farde L, Wiesel F-A, Stone-Elander S, Halldin C, Nordströ A-L, Hall H, Sedvall G. 1990. D2 dopamine receptors in neuroleptic-naive schizophrenic patients. Arch Gen Psychiatry 47:213-219.
18. Geijer T, Neiman J, Rydberg U, Gyllander A, Jösson E, Sedvall G, Valverius P, Terenius L. 1994. Dopamine D2 receptor gene polymorphisms in Scandinavian chronic alcoholics. Eur Arch Psychiatry Clin Neurosci 244:26-32.
19. Gelernter J, Kranzler H, Coccaro E, Siever L, New A, Mulgrew CL. 1997. D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. Am J Hum Genet 61:1144-1152.
20. Gray JA. 1987. The psychology of fear and stress. Cambridge, UK: Cambridge University Press.
21. Gustavsson JP. 1997. Stability and validity of self-reported personality traits. Contributions to the evaluation of the Karolinska Scales of Personality [thesis]. Stockholm: Karolinska Institute, p 1-85.
22. Gustavsson JP, Pedersen NL, Åsberg M, Schalling D. 1996a. Exploration into the sources of individual differences in aggression-, hostility- and anger-related (AHA) personality traits. Pers Individ Diff 21:1067-1071.
23. Gustavsson JP, Pedersen NL, Åberg M, Schalling D. 1996b. Origins of individual differences in anxiety proness: a twin/adoption study of the anxiety-related scales from the Karolinska Scales of Personality. Acta Psychiatr Scand 93:460-469.
24. Gustavsson JP, Weinryb RM, Göransson S, Pedersen NL, åberg M. 1997. Stability and predictive ability of personality traits across 9 years. Pers Individ Diff 22:783-791.
25. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP. 1996. Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
26. Helleday J, Edman G, Ritzén EM, Siewers B. 1993. Personality traits and platelet MAO activity in women with congenital adrenal hyperplasia (CAH). Psychoneuroendocrinology 18:343-354.
27. Jösson EG, Nöthen MM, Gustavsson JP, Neidt H, BrenéS, Tylec A, Propping P, Sedvall GC. 1997. No evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms. Am J Psychiatry 154:697-699.
28. Jösson EG, Nöthen MM, Gustavsson JP. Neidt H, Forslund K, Mattila-Evenden M, Rylander G, Propping P, Åsberg M. 1998. Lack of association between dopamine D4 receptor gene and personality traits. Psychol Med 28:985-989.
29. Lesch K-P, Balling U, Gross J, Strauss K, Wolozin B, Murphy D, Riederer P. 1994. Organization of the human serotonin transporter gene. J Neural Transm 95:157-162.
30. Lesch K-P, Bengel D, Heils A, Sabol SZ, Grenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
31. Loehlin JC. 1992. Genes and environment in personality development. Newbury Park, California: Sage Publications.
32. Malhotra AK, Virkkunen M, Rooney W, Eggert E, Linnoila M, Goldman D. 1996. The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. Mol Psychiatry 1:388-391.