메뉴 건너뛰기




Volumn 7, Issue 6, 2005, Pages 696-707

Combined immunization with fusion genes of mutated E7 gene of human papillomavirus type 16 did not enhance antitumor effect

Author keywords

E7 oncogene; Fusion genes; Gene gun; HPV; HSP; MHC class I

Indexed keywords

DNA VACCINE; HEAT SHOCK PROTEIN 70; HYBRID PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN E7; VIRUS VECTOR;

EID: 21044433923     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.733     Document Type: Article
Times cited : (8)

References (54)
  • 1
    • 0030068375 scopus 로고    scopus 로고
    • Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
    • Lin KY, Guarnieri FG, Staveley-O'Carroll KF, et al. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res 1996; 56: 21-26.
    • (1996) Cancer Res. , vol.56 , pp. 21-26
    • Lin, K.Y.1    Guarnieri, F.G.2    Staveley-O'Carroll, K.F.3
  • 2
    • 0037424159 scopus 로고    scopus 로고
    • Immunisation with modified HPV16 E7 genes against mouse oncogenic TC-1 cell sublines with downregulated expression of MHC class I molecules
    • Smahel M, Sima P, Ludvikova V, Marinov I, Pokorna D, Vonka V. Immunisation with modified HPV16 E7 genes against mouse oncogenic TC-1 cell sublines with downregulated expression of MHC class I molecules. Vaccine 2003; 21: 1125-1136.
    • (2003) Vaccine , vol.211 , pp. 125-1136
    • Smahel, M.1    Sima, P.2    Ludvikova, V.3    Marinov, I.4    Pokorna, D.5    Vonka, V.6
  • 3
    • 0035866607 scopus 로고    scopus 로고
    • Modified HPV16 E7 genes as DNA vaccine against E7-containing oncogenic cells
    • Smahel M, Sima P, Ludvikova V, Vonka V. Modified HPV16 E7 genes as DNA vaccine against E7-containing oncogenic cells. Virology 2001; 281: 231-238.
    • (2001) Virology , vol.281 , pp. 231-238
    • Smahel, M.1    Sima, P.2    Ludvikova, V.3    Vonka, V.4
  • 4
    • 0023711798 scopus 로고
    • Calcium phosphate-mediated gene transfer: A highly efficient transfection system for stably transforming cells with plasmid DNA
    • Chen CA, Okayama H. Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. Biotechniques 1988; 6: 632-638.
    • (1988) Biotechniques , vol.6 , pp. 632-638
    • Chen, C.A.1    Okayama, H.2
  • 5
    • 0031262740 scopus 로고    scopus 로고
    • Cervical carcinoma cells transfected with the CD80 gene elicit a primary cytotoxic T lymphocyte response specific for HPV 16 E7 antigens
    • Kaufmann AM, Gissmann L, Schreckenberger C, Qiao L. Cervical carcinoma cells transfected with the CD80 gene elicit a primary cytotoxic T lymphocyte response specific for HPV 16 E7 antigens. Cancer Gene Ther 1997; 4: 377-382.
    • (1997) Cancer Gene Ther. , vol.4 , pp. 377-382
    • Kaufmann, A.M.1    Gissmann, L.2    Schreckenberger, C.3    Qiao, L.4
  • 6
    • 0027320440 scopus 로고
    • Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells
    • Feltkamp MC, Smits HL, Vierboom MP, et al. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur J Immunol 1993; 23: 2242-2249.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2242-2249
    • Feltkamp, M.C.1    Smits, H.L.2    Vierboom, M.P.3
  • 7
    • 0025955536 scopus 로고
    • A 'public' T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes
    • Tindle RW, Fernando GJP, Sterling JC, Frazer IH. A 'public' T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes. Proc Natl Acad Sci U S A 1991; 88: 5887-5891.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.885 , pp. 887-5891
    • Tindle, R.W.1    Fernando, G.J.P.2    Sterling, J.C.3    Frazer, I.H.4
  • 9
    • 0032005477 scopus 로고    scopus 로고
    • Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
    • Murali-Krishna K, Altman JD, Suresh M, et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 1998; 8: 177-187.
    • (1998) Immunity , vol.8 , pp. 177-187
    • Murali-Krishna, K.1    Altman, J.D.2    Suresh, M.3
  • 10
    • 0029583864 scopus 로고
    • Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens
    • Wu TC, Guarnieri FG, Staveley-O'Carroll KF, et al. Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens. Proc Natl Acad Sci U S A 1995; 92: 11 671-11 675.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 11671-11675
    • Wu, T.C.1    Guarnieri, F.G.2    Staveley-O'Carroll, K.F.3
  • 11
    • 0030818414 scopus 로고    scopus 로고
    • Heat stress proteins and transcription factors
    • Nover L, Scharf KD. Heat stress proteins and transcription factors. Cell Mol Life Sci 1997; 53: 80-103.
    • (1997) Cell Mol. Life Sci. , vol.53 , pp. 80-103
    • Nover, L.1    Scharf, K.D.2
  • 12
    • 0034824676 scopus 로고    scopus 로고
    • DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection
    • Planelles L, Thomas MC, Alonso C, Lopez MC. DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection. Infect Immun 2001; 69: 6558-6563.
    • (2001) Infect. Immun. , vol.69 , pp. 6558-6563
    • Planelles, L.1    Thomas, M.C.2    Alonso, C.3    Lopez, M.C.4
  • 13
    • 0031964659 scopus 로고    scopus 로고
    • Characterization of the immunostimulatory properties of Leishmania infantum HSP70 by fusion to the Escherichia coli maltose-binding protein in 3normal and nu/nu BALB/c mice
    • Rico AI, Del Real G, Soto M, et al. Characterization of the immunostimulatory properties of Leishmania infantum HSP70 by fusion to the Escherichia coli maltose-binding protein in 3normal and nu/nu BALB/c mice. Infect Immunol 1998; 66: 347-352.
    • (1998) Infect. Immunol. , vol.66 , pp. 347-352
    • Rico, A.I.1    Del Real, G.2    Soto, M.3
  • 14
    • 0030028801 scopus 로고    scopus 로고
    • Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24
    • Suzue K, Young RA. Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. J Immunol 1996; 156: 873-879.
    • (1996) J. Immunol. , vol.156 , pp. 873-879
    • Suzue, K.1    Young, R.A.2
  • 15
    • 0034782206 scopus 로고    scopus 로고
    • Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70
    • Udono H, Yamano T, Kawabata Y, Ueda M, Yui K. Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70. Int Immunol 2001; 13: 1233-1242.
    • (2001) Int. Immunol. , vol.13 , pp. 1233-1242
    • Udono, H.1    Yamano, T.2    Kawabata, Y.3    Ueda, M.4    Yui, K.5
  • 16
    • 0034677127 scopus 로고    scopus 로고
    • In vivo cytotoxic T lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4(+) T cell independent
    • Huang Q, Richmond JF, Suzue K, Eisen HN, Young RA. In vivo cytotoxic T lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4(+) T cell independent. J Exp Med 2000; 191: 403-408.
    • (2000) J. Exp. Med. , vol.191 , pp. 403-408
    • Huang, Q.1    Richmond, J.F.2    Suzue, K.3    Eisen, H.N.4    Young, R.A.5
  • 17
    • 0345164329 scopus 로고    scopus 로고
    • Priming of CD8+ CTL effector cells in mice by immunization with a stress protein-influenza virus nucleoprotein fusion molecule
    • Anthony LS, Wu H, Sweet H, Turnnir C, Boux LJ, Mizzen LA. Priming of CD8+ CTL effector cells in mice by immunization with a stress protein-influenza virus nucleoprotein fusion molecule. Vaccine 1999; 17: 373-383.
    • (1999) Vaccine , vol.17 , pp. 373-383
    • Anthony, L.S.1    Wu, H.2    Sweet, H.3    Turnnir, C.4    Boux, L.J.5    Mizzen, L.A.6
  • 18
    • 0035280984 scopus 로고    scopus 로고
    • Analysis of the adjuvant effect of recombinant Leishmania infantum Hsp83 protein as a tool for vaccination
    • Echeverria P, Dran G, Pereda G, et al. Analysis of the adjuvant effect of recombinant Leishmania infantum Hsp83 protein as a tool for vaccination. Immunol Lett 2001; 76: 107-110.
    • (2001) Immunol. Lett. , vol.6 , pp. 107-110
    • Echeverria, P.1    Dran, G.2    Pereda, G.3
  • 19
    • 0031793127 scopus 로고    scopus 로고
    • Heat shock protein 70 kDa: Molecular biology, biochemistry, and physiology
    • Kiang JG, Tsokos GC. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther 1998; 80: 183-201.
    • (1998) Pharmacol. Ther. , vol.80 , pp. 183-201
    • Kiang, J.G.1    Tsokos, G.C.2
  • 20
    • 0034788572 scopus 로고    scopus 로고
    • Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen
    • Cheng WF, Hung CF, Chai CY, et al. Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen. J Clin Invest 2001; 108: 669-678.
    • (2001) J. Clin. Invest. , vol.108 , pp. 669-678
    • Cheng, W.F.1    Hung, C.F.2    Chai, C.Y.3
  • 21
    • 0032753789 scopus 로고    scopus 로고
    • Cell transformation by the E7 oncoprotein of human papillomavirus type 16: Interactions with nuclear and cytoplasmic target proteins
    • Zwerschke W, Jansen-Durr P. Cell transformation by the E7 oncoprotein of human papillomavirus type 16: interactions with nuclear and cytoplasmic target proteins. Adv Cancer Res 2000; 78: 1-29.
    • (2000) Adv. Cancer Res. , vol.78 , pp. 1-29
    • Zwerschke, W.1    Jansen-Durr, P.2
  • 22
    • 0030667939 scopus 로고    scopus 로고
    • Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway
    • Suzue K, Zhou X, Eisen HN, Young RA. Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proc Natl Acad Sci U S A 1997; 94: 13 146-13 151.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 13146-13151
    • Suzue, K.1    Zhou, X.2    Eisen, H.N.3    Young, R.A.4
  • 23
    • 0032838682 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E7 DNA vaccine: Mutation in the open reading frame of E7 enhances specific cytotoxic T-lymphocyte induction and antitumor activity
    • Shi W, Bu P, Liu J, Polack A, Fisher S, Qiao L. Human papillomavirus type 16 E7 DNA vaccine: mutation in the open reading frame of E7 enhances specific cytotoxic T-lymphocyte induction and antitumor activity. J Virol 1999; 73: 7877-7881.
    • (1999) J. Virol. , vol.73 , pp. 7877-7881
    • Shi, W.1    Bu, P.2    Liu, J.3    Polack, A.4    Fisher, S.5    Qiao, L.6
  • 24
    • 0033838826 scopus 로고    scopus 로고
    • Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guerin (BCG) hsp65 HPV16 E7
    • Chu NR, Wu HB, Wu T, Boux LJ, Siegel MI, Mizzen LA. Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guerin (BCG) hsp65 and HPV16 E7. Clin Exp Immunol 2000; 121: 216-225.
    • (2000) Clin. Exp. Immunol. , vol.121 , pp. 216-225
    • Chu, N.R.1    Wu, H.B.2    Wu, T.3    Boux, L.J.4    Siegel, M.I.5    Mizzen, L.A.6
  • 25
    • 0034652784 scopus 로고    scopus 로고
    • Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene
    • Chen CH, Wang TL, Hung CF, et al. Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene. Cancer Res 2000; 60: 1035-1042.
    • (2000) Cancer Res. , vol.60 , pp. 1035-1042
    • Chen, C.H.1    Wang, T.L.2    Hung, C.F.3
  • 26
    • 0035873726 scopus 로고    scopus 로고
    • Enhancement of Sindbis virus self-replicating RNA vaccine potency by linkage of Mycobacterium tuberculosis heat shock protein 70 gene to an antigen gene
    • Cheng WF, Hung CF, Chai CY, et al. Enhancement of Sindbis virus self-replicating RNA vaccine potency by linkage of Mycobacterium tuberculosis heat shock protein 70 gene to an antigen gene. J Immunol 2001; 166: 6218-6226.
    • (2001) J. Immunol. , vol.166 , pp. 6218-6226
    • Cheng, W.F.1    Hung, C.F.2    Chai, C.Y.3
  • 28
    • 0033695064 scopus 로고    scopus 로고
    • A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins
    • Cho BK, Palliser D, Guillen E, et al. A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins. Immunity 2000; 12: 263-272.
    • (2000) Immunity , vol.12 , pp. 263-272
    • Cho, B.K.1    Palliser, D.2    Guillen, E.3
  • 29
    • 0033994625 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer
    • Liu DW, Tsao YP, Kung JT, et al. Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer. J Virol 2000; 74: 2888-2894.
    • (2000) J. Virol. , vol.74 , pp. 2888-2894
    • Liu, D.W.1    Tsao, Y.P.2    Kung, J.T.3
  • 30
    • 0035077790 scopus 로고    scopus 로고
    • Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen
    • Hsu KF, Hung CF, Cheng WF, et al. Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen. Gene Ther 2001; 8: 376-383.
    • (2001) Gene Ther. , vol.8 , pp. 376-383
    • Hsu, K.F.1    Hung, C.F.2    Cheng, W.F.3
  • 31
    • 0037299740 scopus 로고    scopus 로고
    • Improving DNA vaccine potency via modification of professional antigen presenting cells
    • Hung CF, Wu TC. Improving DNA vaccine potency via modification of professional antigen presenting cells. Curr Opin Mol Ther 2003; 5: 20-24.
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 20-24
    • Hung, C.F.1    Wu, T.C.2
  • 32
    • 0036114412 scopus 로고    scopus 로고
    • Activity of HspE7, a novel immunotherapy, in patients with anogenital warts
    • Goldstone SE, Palefsky JM, Winnett MT, Neefe Jr. Activity of HspE7, a novel immunotherapy, in patients with anogenital warts. Dis Colon Rectum 2002; 45: 502-507.
    • (2002) Dis. Colon Rectum , vol.45 , pp. 502-507
    • Goldstone, S.E.1    Palefsky, J.M.2    Winnett, M.T.3    Neefe, Jr.4
  • 33
    • 0034879521 scopus 로고    scopus 로고
    • Technology evaluation: HspE7, StressGen Biotechnologies Corp
    • Hunt S. Technology evaluation: HspE7, StressGen Biotechnologies Corp. Curr Opin Mol Ther 2001; 3: 413-417.
    • (2001) Curr. Opin. Mol. Ther. , vol.3 , pp. 413-417
    • Hunt, S.1
  • 34
    • 0041524186 scopus 로고    scopus 로고
    • CD8+ T cells, NK cells and IFN-gamma are important for control of tumor with downregulated MHC class I expression by DNA vaccination
    • Cheng WF, Hung CF, Lin KY, et al. CD8+ T cells, NK cells and IFN-gamma are important for control of tumor with downregulated MHC class I expression by DNA vaccination. Gene Ther 2003; 10: 1311-1320.
    • (2003) Gene Ther. , vol.10 , pp. 1311-1320
    • Cheng, W.F.1    Hung, C.F.2    Lin, K.Y.3
  • 35
    • 0035989335 scopus 로고    scopus 로고
    • Trypanosoma cruzi heat-shock protein-70 kDa, alone or fused to the parasite KMP11 antigen, induces functional maturation of murine dendritic cells
    • Planelles L, Thomas M, Pulgar M, Maranon C, Grabbe S, Lopez MC. Trypanosoma cruzi heat-shock protein-70 kDa, alone or fused to the parasite KMP11 antigen, induces functional maturation of murine dendritic cells. Immunol Cell Biol 2002; 80: 241-247.
    • (2002) Immunol. Cell Biol. , vol.80 , pp. 241-247
    • Planelles, L.1    Thomas, M.2    Pulgar, M.3    Maranon, C.4    Grabbe, S.5    Lopez, M.C.6
  • 36
    • 0037562679 scopus 로고    scopus 로고
    • DNA vaccines against HPV-16 E7-expressing tumour cells
    • De Marco F, Hallez S, Brulet JM, et al. DNA vaccines against HPV-16 E7-expressing tumour cells. Anticancer Res 2003; 23: 1449-1454.
    • (2003) Anticancer Res. , vol.23 , pp. 1449-1454
    • De Marco, F.1    Hallez, S.2    Brulet, J.M.3
  • 37
    • 0037526586 scopus 로고    scopus 로고
    • Therapeutic vaccination for the treatment of mucosotropic human papillomavirus-associated disease
    • Chu NR. Therapeutic vaccination for the treatment of mucosotropic human papillomavirus-associated disease. Expert Opin Biol Ther 2003; 3: 477-486.
    • (2003) Expert Opin. Biol. Ther. , vol.3 , pp. 477-486
    • Chu, N.R.1
  • 38
    • 0035400487 scopus 로고    scopus 로고
    • A generic capture ELISA for recombinant proteins fused to glutathione S-transferase: Validation for HPV serology
    • Sehr P, Zumbach K, Pawlita M. A generic capture ELISA for recombinant proteins fused to glutathione S-transferase: validation for HPV serology. J Immunol Methods 2001; 253: 153-162.
    • (2001) J. Immunol. Methods , vol.253 , pp. 153-162
    • Sehr, P.1    Zumbach, K.2    Pawlita, M.3
  • 39
    • 0036805546 scopus 로고    scopus 로고
    • HPV antibody detection by ELISA with capsid protein L1 fused to glutathione S-transferase
    • Sehr P, Muller M, Hopfl R, Widschwendter A, Pawlita M. HPV antibody detection by ELISA with capsid protein L1 fused to glutathione S-transferase. J Virol Methods 2002; 106: 61-70.
    • (2002) J. Virol. Methods. , vol.106 , pp. 61-70
    • Sehr, P.1    Muller, M.2    Hopfl, R.3    Widschwendter, A.4    Pawlita, M.5
  • 40
    • 13644274069 scopus 로고    scopus 로고
    • Enhancement of immunogenicity of HPV16 E7 oncogene by fusion with E. coli β-glucuronidase
    • in press
    • Smahel M, Pokorna D, Mackova J, Vlasak J. Enhancement of immunogenicity of HPV16 E7 oncogene by fusion with E. coli β-glucuronidase. J Gene Med. 2005; in press.
    • (2005) J. Gene. Med.
    • Smahel, M.1    Pokorna, D.2    Mackova, J.3    Vlasak, J.4
  • 42
    • 0041619161 scopus 로고    scopus 로고
    • Repeated DNA vaccinations elicited qualitatively different cytotoxic T lymphocytes and improved protective antitumor effects
    • Cheng WF, Hung CF, Pai SI, et al. Repeated DNA vaccinations elicited qualitatively different cytotoxic T lymphocytes and improved protective antitumor effects. J Biomed Sci 2002; 9: 675-687.
    • (2002) J. Biomed. Sci. , vol.9 , pp. 675-687
    • Cheng, W.F.1    Hung, C.F.2    Pai, S.I.3
  • 44
    • 3142704466 scopus 로고    scopus 로고
    • Comparison of HPV DNA vaccines employing intracellular targeting strategies
    • in press
    • Kim JW, Hung CF, Juang J, et al. Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther. 2005; in press.
    • (2005) Gene Ther.
    • Kim, J.W.1    Hung, C.F.2    Juang, J.3
  • 45
    • 0344234343 scopus 로고    scopus 로고
    • DNA immunisation: Altering the cellular localisation of expressed protein and the immunisation route allows manipulation of the immune response
    • Morel PA, Falkner D, Plowey J, Larregina AT, Falo LD. DNA immunisation: altering the cellular localisation of expressed protein and the immunisation route allows manipulation of the immune response. Vaccine 2004; 22: 447-456.
    • (2004) Vaccine , vol.22 , pp. 447-456
    • Morel, P.A.1    Falkner, D.2    Plowey, J.3    Larregina, A.T.4    Falo, L.D.5
  • 46
    • 0023201676 scopus 로고
    • The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein
    • Smotkin D, Wettstein FO. The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein. J Virol 1987; 61: 1686-1689.
    • (1987) J. Virol. , vol.61 , pp. 1686-1689
    • Smotkin, D.1    Wettstein, F.O.2
  • 47
    • 0038119610 scopus 로고    scopus 로고
    • Fusion to a carrier protein and a synthetic propeptide enhances E7 HPV-16 production and secretion in Lactococcus lactis
    • Bermudez-Humaran LG, Cortes-Perez NG, Le Loir Y, et al. Fusion to a carrier protein and a synthetic propeptide enhances E7 HPV-16 production and secretion in Lactococcus lactis. Biotechnol Prog 2003; 19: 1101-1104.
    • (2003) Biotechnol. Prog. , vol.19 , pp. 1101-1104
    • Bermudez-Humaran, L.G.1    Cortes-Perez, N.G.2    Le Loir, Y.3
  • 48
    • 0036184546 scopus 로고    scopus 로고
    • Immunization strategy against cervical cancer involving an alphavirus vector expressing high levels of a stable fusion protein of human papillomavirus 16 E6 and E7
    • Daemen T, Regts J, Holtrop M, Wilschut J. Immunization strategy against cervical cancer involving an alphavirus vector expressing high levels of a stable fusion protein of human papillomavirus 16 E6 and E7. Gene Ther 2002; 9: 85-94.
    • (2002) Gene Ther. , vol.9 , pp. 85-94
    • Daemen, T.1    Regts, J.2    Holtrop, M.3    Wilschut, J.4
  • 49
    • 0034735901 scopus 로고    scopus 로고
    • Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: Targeting via ubiquitination of the N-terminal residue
    • Reinstein E, Scheffner M, Oren M, Ciechanover A, Schwartz A. Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. Oncogene 2000; 19: 5944-5950.
    • (2000) Oncogene , vol.19 , pp. 5944-5950
    • Reinstein, E.1    Scheffner, M.2    Oren, M.3    Ciechanover, A.4    Schwartz, A.5
  • 50
    • 0035852322 scopus 로고    scopus 로고
    • Polynucleotide viral vaccines: Codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy
    • Liu WJ, Zhao KN, Gao FG, Leggatt GR, Fernando GJ, Frazer IH. Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy. Vaccine 2001; 20: 862-869.
    • (2001) Vaccine , vol.20 , pp. 862-869
    • Liu, W.J.1    Zhao, K.N.2    Gao, F.G.3    Leggatt, G.R.4    Fernando, G.J.5    Frazer, I.H.6
  • 51
    • 0028170748 scopus 로고
    • A qualitative progression in HIV type 1 glycoprotein 120-specific cytotoxic cellular and humoral immune responses in mice receiving a DNA-based glycoprotein 120 vaccine
    • Fuller DH, Haynes Jr. A qualitative progression in HIV type 1 glycoprotein 120-specific cytotoxic cellular and humoral immune responses in mice receiving a DNA-based glycoprotein 120 vaccine. AIDS Res Hum Retroviruses 1994; 10: 1433-1441.
    • (1994) AIDS Res. Hum. Retroviruses , vol.10 , pp. 1433-1441
    • Fuller, D.H.1    Haynes, Jr.2
  • 52
    • 0005457558 scopus 로고    scopus 로고
    • First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: Safety and host response
    • MacGregor RR, Boyer JD, Ugen KE, et al. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response. J Infect Dis 1998; 178: 92-100.
    • (1998) J. Infect. Dis. , vol.178 , pp. 92-100
    • MacGregor, R.R.1    Boyer, J.D.2    Ugen, K.E.3
  • 53
    • 0033120964 scopus 로고    scopus 로고
    • Dose dependence of CTL precursor frequency induced by a DNA vaccine and correlation with protective immunity against influenza virus challenge
    • Fu TM, Guan L, Friedman A, et al. Dose dependence of CTL precursor frequency induced by a DNA vaccine and correlation with protective immunity against influenza virus challenge. J Immunol 1999; 162: 4163-4170.
    • (1999) J. Immunol. , vol.162 , pp. 4163-4170
    • Fu, T.M.1    Guan, L.2    Friedman, A.3
  • 54
    • 0033380078 scopus 로고    scopus 로고
    • Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs
    • Chen CH, Ji H, Suh KW, Choti MA, Pardoll DM, Wu TC. Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs. Gene Ther 1999; 6: 1972-1981.
    • (1999) Gene Ther. , vol.61 , pp. 972-1981
    • Chen, C.H.1    Ji, H.2    Suh, K.W.3    Choti, M.A.4    Pardoll, D.M.5    Wu, T.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.