Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24

Journal of Immunology

Volumn 156, Issue 2, 1996, Pages 873-879

  Suzue, Kimiko ^a,b   Young, Richard A ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; HEAT SHOCK PROTEIN 70; HYBRID PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION;

AIDS VACCINES; ANIMALS; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; BASE SEQUENCE; FEMALE; GENETIC VECTORS; HIV ANTIBODIES; HIV CORE PROTEIN P24; HSP70 HEAT-SHOCK PROTEINS; IMMUNITY, CELLULAR; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, SYNTHETIC;

EID: 0030028801     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Young, R. A. 1990 Stress proteins and immunology. Annu. Rev. Immunol. 8:401.
2. Kaufmann, S. H. 1990. Heat shock proteins and the immune response. Immunol Today 11:129.
3. Young, D. B , A. Mehlert, and D. F. Smith. 1990. Stress proteins and infectious diseases. In Stress Proteins in Biology and Medicine. R. I Morimoto, A Tissieres, and C. Georgopoulos, eds. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 131.
4. Murray, P. J., and R A. Young 1992 Stress and immunological recognition in host-pathogen interactions J. Bacteriol. 174:4193
5. Kaufmann, S H. E , and B. Schoel. 1994 Heat shock proteins as antigens in immunity against infection and self. In The Biology of Heat Shock Proteins and Molecular Chaperones R. I. Morimoto, A Tissieres, and C. Georgopoulos, eds Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 495.
6. Adams, E., R. J. Garsia, L. Hellqvist, P. Holt, and A. Basten. 1990. T cell reactivity to the purified mycobacterial antigens p65 and p70 in leprosy patients and their household contacts Clin Exp. Immunol. 80.206.
7. Husson, R. N , and R. A. Young. 1987. Genes for the major protein antigens of Mycobacterium tuberculosis: the etiologic agents of tuberculosis and leprosy share an immunodominant antigen. Proc. Natl. Acad. Sci. USA 84:1679.
8. Young, D B , L. Kent, and R. A. Young. 1987. Screening of a recombinant mycobacterial DNA library with polyclonal antiserum and molecular weight analysis of expressed antigens. Infect. Immun. 55:1421
9. Young, D , R Lathigra, R. Hendrix, D Sweetser, and R. A. Young. 1988 Stress proteins are immune targets in leprosy and tuberculosis. Proc. Natl. Acad. Sci USA 85:4267
10. Nerland, A. H., A S. Mustafa, D. Sweetser, T. Godal, and R A. Young. 1988. A protein antigen of Mycobacterium leprae is related to a family of small heat shock proteins. J Bacteriol. 170:5919.
11. Verbon, A., R. A Hartskeerl, A. Schuitema, A H. Kolk, D B. Young, and R. Lathigra. 1992. The 14,000-molecular-weight antigen of Mycobacterium tuberculosis is related to the α-crystallin family of low-molecular-weight heat shock proteins. J. Bacteriol 174:1352.
12. Mehra, V., B R. Bloom, A C. Bajardi, C. L. Grisso, P. A Sieling, D. Alland, J. Convit, X. D. Fan, S. W. Hunter, P. J. Brennan, T H Rea, and R L. Modlin 1992. A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein. J. Exp. Med. 175:275.
13. Baird, P N , L. M Hall, and A. R. Coates. 1988 A major antigen from Mycobacterium tuberculosis which is homologous 10 the heat shock proteins groES from E. coli and the htpA gene product of Coxiella burneti. Nucleic Acids Res 16:9047.
14. Kaufmann, S. H , U. Vath, J E. Thole, J. D Van Embden, and F. Emmrich 1987. Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein. Eur. J. Immunol 17.351.
15. Munk, M E., B. Schoel, and S. H. Kaufmann. 1988 T cell responses of normal individuals towards recombinant protein antigens of Mycobacterium tuberculosis. Eur. J. Immunol 18:1835.
16. Mehra, V., D. Sweetser, and R. A. Young. 1986. Efficient mapping of protein antigenic determinants Proc. Natl. Acad Sci. USA 83:7013.
17. Thole, J. E , W C van Schooten, W. J Keulen, P. W. Hermans, A. A. Janson, R. R. de Vries, A. H. Kolk, and J. D. van Embden. 1988. Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG. Infect. Immun. 56:1633
18. Richman, S. J., T. S. Vedvick, and R. T Reese 1989 Peptide mapping of conformational epitopes in a human malarial parasite heat shock protein J Immunol 143:285
19. Requena, J M., M. Soto, F Guzman, A. Maekelt, O. Noya, M E Patarroyo, and C. Alonso. 1993. Mapping of antigenic determinants of the T cruzi hsp70 in chagasic and healthy individuals Mol Immunol. 30:1115.
20. Adams, E., W. Britton, A. Morgan, S. Sergeantson, and A. Basten. 1994. Individuals from different populations identify multiple and diverse T-cell determinants on Mycobacterial hsp70. Scand. J Immunol. 39:588.
21. Lamb, J. R , J. Ivanyi, A D. Rees, J. B Rothbard, K Howland, R. A. Young, and D. B. Young. 1987. Mapping of T cell epitopes using recombinant antigens and synthetic peptides. EMBO J. 6:1245.
22. Van Schooten, W. C., T. H. Ottenhoff, P R. Klaiser, J. Thole, R. R. De Vries, and A H. Kolk. 1988. T cell epitopes on the 36K and 65K Mycobacterium leprae antigens defined by human T cell clones. Eur. J. Immunol. 18:849.
23. Munk, M E., T. M. Shinnick, and S. H. Kaufmann 1990 Epitopes of the mycobacterial heat shock protein 65 for human T cells comprise different structures. Immunobiology 180:272.
24. Oftung, F., A. Geluk, K E. Lundin, R H. Meloen, J. E. Thole, A. S Mustafa, and T. H. Ottenhoff 1994. Mapping of multiple HLA class II-restricted T-cell epitopes of the mycobacterial 70-kilodalton heat shock protein. Infect. Immun. 62:5411
25. Neidhardt, F. C., and R A. VanBogelen. 1987 Heat shock response In Escherichia coli and Salmonella typhimurium. Cellular and Molecular Biology, F. C Neidhardt, J L Ingraham, K. B. Low, B. Magasanik, M Schaechter, and H. E Umbarger, eds. American Society for Microbiology, Washington, DC, p. 1334.
26. Craig, E A 1985. The heat shock response. CRC Crit Rev. Biochem. 18:239
27. Boorstein, W. R., T. Ziegelhoffer, and E A. Craig 1994 Molecular evolution of the HSP70 multigene family. J. Mol Evol. 38:1
28. Lussow, A R., C. Barrios, J van Embden, R. Van der Zee, A. S Verdini, A. Pessi, J. A. Louis, P H Lambert, and G. Del Giudice 1991. Mycobacterial heat-shock proteins as carrier molecules. Eur. J. Immunol 21:2297.
29. Barrios, C , A. R. Lussow, J. Van Embden, R Van der Zee, R. Rappuoli, P. Costantino, J. A Louis, P. H. Lambert, and G. Del Giudice. 1992. Mycobacterial heat-shock proteins as carrier molecules. II. The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guerin priming. Eur. J Immunol 22, 1365
30. Perraut, R., A. R. Lussow, S. Gavoille, O Garraud, H. Matile, C. Tougne, J. Van Embden, R. Van der Zee, P. H. Lambert, J. Gysin, and G. Del Giudice. 1993. Successful primate immunization with peptides conjugated to purified protein derivative or mycobacterial heat shock proteins in the absence of adjuvants. Clin Exp. Immunol. 93:382.
31. Fisher, A. G., E. Collalti, L Ratner, R C Gallo, and F. Wong-Staal. 1985. A molecular clone of HTLV-III with biological activity. Nature 316:262.
32. Tabor, S., and C. C Richardson 1985. A bacteriophage T7 RNA polymerase/ promoter system for controlled exclusive expression of specific genes. Proc. Natl. Acad. Sci USA 82:1074.
33. Studier, F. W., A. H Rosenberg, J. J. Dunn, and J. W. Dubendorff. 1990. Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 185:60
34. Laemmli, U K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
35. Aldovini, A., and R. A. Young. 1991. Humoral and cell-mediated immune responses to live recombinant BCG-HIV vaccines. Nature 351:479.
36. Hanna, N , E. Jarosch, and S. Leskowitz. 1972. Altered immunogenicity produced by change in mode of linkage of hapten to carrier. Proc Soc. Exp. Biol. Med. 140:89.
37. Klaus, G. G., and A. M. Cross 1974. The influence of epitope density on the immunological properties of hapten-prorein conjugates I. Characteristics of the immune response to hapten-coupled albumen with varying epitope density. Cell. Immunol. 14:226.
38. Snippe, H., W. G Graven, and P. J Willems 1975. Antibody formation in the mouse induced by hapten-carrier complexes. Immunology 28:885.
39. Anderson, P. W., M. E. Pichichero, E C Stein, S. Porcelli, R. F. Betts, D. M. Connuck, D. Korones, R. A. Insel, J. M. Zahradnik, and R. Eby. 1989. Effect of oligosaccharide chain length, exposed terminal group, and hapten loading on the antibody response of human adults and infants to vaccines consisting of Haemophilus infuenzae type b capsular antigen unterminally coupled to the diphtheria protein CRM197. J Immunol 142:2464
40. Dintzis, R. Z. 1992. Rational design of conjugate vaccines. Pediatr. Res. 32:376.
41. Cox, J. H , J. Ivanyi, D. B. Young, J. R. Lamb, A. D. Syred, and M. J. Francis. 1988. Orientation of epitopes influences the immunogenicity of synthetic peptide dimers. Eur J Immunol 18:2015.
42. Lowenadler, B , N. Lycke, C. Svanholm, A. M. Svennerholm, K. Krook, and M. Gidlund. 1992. T and B cell responses to chimeric proteins containing heterologous T helper epitopes inserted at different positions Mol. Immunol. 29: 1185.
43. Lowenadler, B., and N Lycke 1994. Fusion proteins with heterologous T helper epitopes: recombinant E. coli heat-stable enterotoxin proteins. Int. Rev. Immunol 11:103.
44. Coffman, R. L., B. W. P. Seymour, D A Lebman, D. D. Hiraki, J. A. Christiansen, B. Shrader, H. M. Cherwinski, H. F. J Savelkoul, F. D. Finkelman, M W. Bond, and T. R. Mosmann. 1988. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102:5.
45. Finkelman, F. D., J. Holmes, I. M. Katona, J F. Urban, M. P. Beckmann, L. S. Park, K. A Schooley, R L. Coffman, T. R. Mosmann, and W E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol 8:303.
46. Mosmann, T. R., and R. L. Coffman 1989 TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
47. Barrios, C., C. Georgopoulos P. H. Lambert, and G. Del Giudice. 1994. Heat shock proteins as carrier molecules: in vivo helper effect mediated by Escherichia coli GroEL and DnaK proteins requires cross-linking with antigen. Clin. Exp. Immunol 98:229
48. Good, M. F., J. A. Berzofsky, W. L. Maloy, Y. Hayashi, N. Fujii, W. T Hockmeyer, and L. H. Miller 1986 Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine: widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine. J Exp. Med. 164:655.
49. Del Giudice, G., J. A. Cooper, J. Merino, A S Verdini, A. Pessi, A. R. Togna, H. D. Engers, G Corradin, and P. H. Lambert 1986. The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-Ab-restricted: possible implications for malaria vaccines. J Immunol. 137:2952.
50. Hedstrom, R., J. Culpepper, R. A. Harrison, N. Agabian, and G Newport. 1987. A major immunogen in Schistosoma mansoni infections is homologous to the heat-shock protein Hsp70. J Exp. Med. 165.1430.
51. Selkirk, M E., D. A. Denham, F. Partono, and R M Maizels. 1989. Heat shock cognate 70 is a prominent immunogen in Brugian filariasis. J. Immunol. 143:299.
52. Rothstein, N. M., G. Higashi, J Yates, and T. V. Rajan. 1989. Onchocerca volvulus heat shock protein 70 is a major immunogen in amicrofilaremic individuals from a filariasis-endemic area. Mol. Biochem. Parasitol. 33:229.
53. Anzola, J , B. J Luft, G. Gorgone, R. J Dattwyler, C. Soderherg, R. Lahesmaa, and G. Peltz. 1992. Borrelia burgdorferi HSP70 homolog, characterization of an immunoreactive stress protein. Infect Immun. 60:3704.
54. Del Giudice, G., A. Gervaix, P. Costantino, C. A. Wyler, C. Tougne, E. R. de Graeff-Meeder, J Van Embden, R Van der Zee, L Nencioni, R. Rappuoli, S. Suter, and P. H. Lambert 1993. Priming to heat shock proteins in infants vaccinated against pertussis. J. Immunol. 150:2025.
55. Vanbuskirk, A., B. L. Crump, E. Margoliash, and S K Pierce 1989. A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family. J. Exp. Med J 70:1799.
56. De Nagel, D C., and S K. Pierce. 1992 A case for chaperones in antigen processing. Immunol Today 13:86.
57. Altman, A., and F J Dixon. 1989. Immunomodifiers in vaccines In Advances in Veterinary Science and Comparative Medicine. J L. Bittte and F. L Murphy, eds. Academic Press, San Diego, p 313
58. Del Giudice, G. 1992. New carriers and adjuvants in the development of vaccines. Curr. Opin. Immunol 4:454