Human papillomavirus type 16 E7 DNA vaccine: Mutation in the open reading frame of E7 enhances specific cytotoxic T-lymphocyte induction and antitumor activity

Journal of Virology

Volumn 73, Issue 9, 1999, Pages 7877-7881

  Shi, Wei ^a   Bu, Ping ^a   Liu, Jianzhong ^a   Polack, Axel ^b   Fisher, Susan ^c   Qiao, Liang ^a,d  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c LOYOLA UNIVERSITY HEALTH SYSTEM   (United States)

^d LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA; VIRUS VACCINE;

ARTICLE; CYTOTOXIC T LYMPHOCYTE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; VIRUS EXPRESSION; VIRUS MUTATION; WART VIRUS;

EID: 0032838682     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.9.7877-7881.1999     Document Type: Article

References (45)

1. Altmann, A., I. Jochmus-Kudielka, R. Frank, H. Gausepohl, U. Moebius, L. Gissmann, and S. C. Meuer. 1992. Definition of immunogenic determinants of the human papillomavirus type 16 nucleoprotein E7. Eur. J. Cancer 28:326-333.
2. Bagarazzi, M. L., J. D. Boyer, V. Ayyavoo, and D. B. Weiner. 1998. Nucleic acid-based vaccines as an approach to immunization against human immunodeficiency virus type-1. Curr. Top. Microbiol. Immunol. 226:107-143.
3. Barbosa, M. S., D. R. Lowy, and J. T. Schiller. 1989. Papillomavirus polypeptides E6 and E7 are zinc-binding proteins. J. Virol. 63:1404-1407.
4. Benton, P. A., and R. C. Kennedy. 1998. DNA vaccines strategies for the treatment of cancer. Curr. Top. Microbiol. Immunol. 226:1-20.
5. Berezutskaya, E., and S. Bagchi. 1997. The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26 S proteasome. J. Biol. Chem. 272:30135-30140.
6. Borysiewicz, L. K., A. Fiander, M. Nimako, S. Man, G. W. Wilkinson, D. Westmoreland, A. S. Evans, M. Adams, S. N. Stacey, M. E. Boursnell, E. Rutherford, J. K. Hickling, and S. C. Inglis. 1996. A recombinant vaccinia virus encoding human papillomavirus types 16 and 18 E6 and E7 proteins as immunotherapy for cervical cancer. Lancet 347:1523-1527.
7. Calarota, S., G. Bratt, S. Nordlund, J. Hinkula, A.-C. Leandersson, E. Sandstrom, and B. Wahren. 1998. Cellular cytotoxic response induced by DNA vaccination in HIV-1 infected patients. Lancet 351:1320-1325.
8. Chen, L. P., E. K. Thomas, S.-L. Hu, I. Hellstrom, and K. E. Hellstrom. 1991. Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen. Proc. Natl. Acad. Sci. USA 88:110-114.
9. Chen, L. P., M. T. Mizuno, M. C. Singhal, S.-L. Hu, D. A. Galloway, I. Hellstrom, and K. E. Hellstrom. 1992. Induction of cytotoxic T lymphocytes specific for a syngeneic tumor expressing the E6 oncoprotein of human papillomavirus type 16. J. Immunol. 148:2617-2621.
10. Comerford, S. A., D. J. McCance, G. Dougan, and J. P. Tite. 1991. Identification of T- and B-cell epitopes of the E7 protein of human papillomavirus type 16. J. Virol. 65:4681-4690.
11. Danko, I., and J. A. Wolff. 1994. Direct gene transfer into muscle. Vaccine 12:1499-1502.
12. Davis, H. L., R. G. Whalen, and B. A. Demeneix. 1993. Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Hum. Gene Ther. 4:151-159.
13. Dyson, N., P. M. Howley, K. M. Münger, and E. Harlow. 1989. The human papillomavirus-16 E7 protein is able to bind to the retinoblastoma gene product. Science 243:934-937.
14. Edmonds, C., and K. H. Vousden. 1989. A point mutational analysis of human papillomavirus type 16 E7 protein. J. Virol. 63:2650-2656.
15. Feltkamp, M. C. W., H. L. Smits, M. P. M. Vierboom, R. P. Minnaar, B. M. de Jongh, J. W. Drijfhout, J. ter Schegget, C. J. Melief, and W. M. Kast. 1993. Vaccination with cytotoxic T lymphocyte epitope containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur. J. Immunol. 23:2242-2249.
16. Feltkamp, M. C. W., G. K. Vreugdenjil, M. P. M. Vierboom, E. Ras, S. H. van der Burg, J. ter Schegget, C. J. M. Melief, and W. M. Kast. 1995. Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16-induced tumors. Eur. J. Immunol. 25:2638-2642.
17. Frazer, I. H. 1996. Immunology of papillomavirus infection. Curr. Opin. Immunol. 8:484-491.
18. Gao, L., B. Chain, C. Sinclair, L. Crawford, J. Zhou, J. Morris, X. Zhu, and H. Stauss. 1994. Immune response to human papillomavirus type 16 E6 gene in a live vaccinia vector. J. Gen. Virol. 75:157-164.
19. Hassett, D. E., and J. L. Whitton. 1996. DNA immunization. Trends Microbiol. 4:307-312.
20. Herd, K., G. J. Fernando, L. A. Dunn, I. H. Frazer, P. Lambert, and R. W. Tindle. 1997. E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B- or Th-repertoires or on the immune response induced or sustained after immunization with E7 protein. Virology 231:155-165.
21. Kadish, A. S., S. L. Romney, R. Ledwidge, R. Tindle, G. J. Fernando, S. Y. Zee, M. A. Van Ranst, and R. D. Burk. 1994. Cell-mediated immune responses to E7 peptides of human papillomavirus type 16 are dependent on the HPV type infecting the cervix whereas serological reactivity is not type-specific. J. Gen. Virol. 75:2277-2284.
22. Kanda, T., A. Furuno, and K. Yoshiike. 1988. Human papillomavirus type 16 open reading frame E7 encodes a transforming gene for rat 3Y1 cells. J. Virol. 62:610-613.
23. Kast, W. M., R. M. P. Brandt, J. Sidney, J. W. Drijfhout, R. T. Kubo, H. M. Grey, C. J. Melief, and A. Sette. 1994. Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins. J. Immunol. 152:3904-3912.
24. Kaufmann, A. M., L. Gissmann, C. Schreckenberger, and L. Qiao. 1997. Cervical carcinoma cells transfected with the CD80 gene elicit a primary cytotoxic T lymphocyte response specific for HPV 16 E7 antigens. Cancer Gene Ther. 4:377-382.
25. Koutsky, L. A., D. A. Galloway, and K. K. Holmes. 1988. Epidemiology of genital human papillomavirus infection. Epidemiol. Rev. 10:122-163.
26. Kozak, M. 1989. The scanning model for translation: an update. J. Cell Biol. 108:229-241.
27. Lin, K. Y., F. G. Guarnieri, K. F. Staveley-O'Carroll, H. I. Levitsky, J. T. August, D. M. Pardoll, and T. C. Wu. 1996. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res. 56:21-26.
28. Massimi, P., D. Pim, A. Storey, and L. Banks. 1996. HPV-16 E7 and adenovirus E1a complex formation with TATA box binding protein is enhanced by casein kinase II phosphorylation. Oncogene 12:2325-2330.
29. Mucke, S., A. Polack, M. Pawlita, D. Zehnpfennig, N. Massoudi, H. Bohlen, W. Doerfler, G. Bornkamm, V. Diehl, and J. Wolf. 1997. Suitability of Epstein-Barr virus-based episomal vectors for expression of cytokine genes in human lymphoma cells. Gene Ther. 4:82-92.
30. Pedroza Martins, L., L. L. Lau, M. S. Asano, and R. Ahmed. 1995. DNA vaccination against persistent viral infection. J. Virol. 69:2574-2582.
31. Ressing, M. E., A. Sette, R. M. P. Brandt, J. Ruppert, P. A. Wentworth, M. Hartman, C. Oseroff, H. M. Grey, C. J. Melief, and W. M. Kast. 1995. Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A *0201-binding peptides. J. Immunol. 154:5934-5943.
32. Robinson, H. L., and C. A. Tores. 1997. DNA vaccines. Semin. Immunol. 9:271-283.
33. Rodriguez, F., J. Zhang, and J. L. Whitton. 1997. DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. J. Virol. 71:8497-8503.
34. Sadovnikova, E., X. Zhu, S. M. Collins, J. Zhou, K. Vousden, L. Crawford, P. Beverley, and H. J. Status. 1995. Limitations of predictive motifs revealed by cytotoxic T lymphocyte epitope mapping of the human papillomavirus E7 protein. Int. Immunol. 6:289-296.
35. Seedorf, K., T. Oltersdorf, G. Krämmer, and W. Röwekamp. 1987. Identification of early proteins of the human papillomaviruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells. EMBO J. 6:139-144.
36. Smotkin, D., and F. O. Wettstein. 1987. The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein. J. Virol. 61: 1686-1689.
37. Strang, G., J. K. Hickling, G. A. McIndoe, K. Howland, D. Wilkinson, H. Ikeda, and J. B. Rothbard. 1990. Human T cell responses to human papillomavirus type 16 L1 and E6 synthetic peptides: identification of T cell determinants, HLA-DR restriction and virus type specificity. J. Gen. Virol. 71:423-431.
38. Tindle, R. W., G. J. Fernando, J. C. Sterling, and I. H. Frazer. 1991. A "public" T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes. Proc. Natl. Acad. Sci. USA 88:5887-5891.
39. Tobery, T. W., and R. F. Siliciano. 1997. Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization. J. Exp. Med. 185:909-920.
40. Townsend, A., J. Bastin, K. Gould, G. Brownlee, M. Andrew, B. Coupar, D. Boyle, S. Chan, and G. Smith. 1988. Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen. J. Exp. Med. 168:1211-1224.
41. Ulmer, J. B., J. C. Sadoff, and M. A. Liu. 1996. DNA vaccines. Curr. Opin. Immunol. 8:531-536.
42. Vousden, K. H., J. Doniger, J. A. DiPaolo, and D. R Lowy. 1988. The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene. Oncogene Res. 3:167-175.
43. Wolff, J. A., R. W. Malone, P. Williams, W. Chong, G. Acsadi, A. Jani, and P. L. Felgner. 1990. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.
44. Zarozinski, C. C., E. F. Fynan, L. K. Selin, H. L. Robinson, and R. M. Welsh. 1995. Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein. J. Immunol. 154:4010-4017.
45. zur Hausen, H. 1991. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13.