In vivo cytotoxic T lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4+ T cell independent

Journal of Experimental Medicine

Volumn 191, Issue 2, 2000, Pages 403-408

  Huang, Qian ^a   Richmond, Joan F L ^a   Suzue, Kimiko ^a   Eisen, Herman N ^b   Young, Richard A ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

CD4+; CD8+; Domain; Knockout; Vaccine

Indexed keywords

AMINO ACID; CHAPERONE; HEAT SHOCK PROTEIN 70; HYBRID PROTEIN; OVALBUMIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOGENICITY; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN BINDING; PROTEIN DOMAIN;

ANIMALS; ANTIGENS, CD4; BETA 2-MICROGLOBULIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HSP70 HEAT-SHOCK PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOBACTERIUM TUBERCULOSIS; OVALBUMIN; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0034677127     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.2.403     Document Type: Article

References (50)

1. Udono, H., and P.K. Srivastava. 1993. Heat shock protein 70-associated peptides elicit specific cancer immunity. J. Exp. Med. 178:1391-1396.
2. + T cells in vivo. Proc. Natl. Acad. Sci. USA. 91:3077-3081.
3. Suto, R., and P.K. Srivastava. 1995. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science. 269:1585-1588.
4. Blanchere, N.E., Z. Li, R.Y. Chandawarkar, R. Suto, N.S. Jaikaria, S. Basu, H. Udono, and P.K. Srivastava. 1997. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J. Exp. Med. 186:1315-1322.
5. Tamura, Y., P. Peng, L. Kang, M. Daou, and P.K. Srivastava, 1997. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science. 278:117-120 .
6. Nair, S., P.A. Wearsch, D.A. Mitchell, J.J. Wassenberg, E. Gilboa, and C.V. Nicchitta. 1999. Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides. J. Immunol. 162:6426-643
7. Suzue, K., X. Zhou, H.N. Eisen, and R.A. Young. 1997. Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proc. Natl. Acad. Sci. USA. 94:13146-13151.
8. Allsopp, C.E., M. Plebanski, S. Gilbert, R.E. Sinden, S. Harris, G. Frankel, G. Dougan, C. Hioe, D. Nixon, E. Paoletti, et al. 1996. Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization. Eur. J. Immunol. 26:1951-1959.
9. Ballard, J.D., R.J. Collier, and M.N. Starnbach. 1996. Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo. Proc. Natl. Acad. Sci. USA. 93:12531-12534.
10. King, C.A., M.B. Spellerberg, D. Zhu, J. Rice, S.S. Sahota, A.R. Thompsett, T.J. Hamblin, J. Radl, and F.K. Stevenson. 1998. DNA vaccines with a single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma. Nat. Med. 4:1281-1286.
11. Carbonetti, N.H., T.J. Irish, C.H. Chen, C.B. O'Connell, G.A. Hadley, U. McNamara, R.G. Tuskan, and G.K. Lewis. 1999. Intracellular delivery of a cytolytic T-lymphocyte epitope peptide by pertussis toxin to major histocompatibility complex class I without involvement of the cytosolic class I antigen processing pathway. Infect. Immun. 67:602-607.
12. Maecker, H.T., D.T. Umetsu, R.H. De Kruyff, and S. Levy. 1997. DNA vaccination with cytokine fusion constructs biases the immune response to ovalbumin. Vaccine. 15:1687-1696.
13. Kang, B.Y., Y.S. Lim, S.W. Chung, E.J. Kim, S.Y. Hwang, and T.S. Kim. 1999. Antigen-specific cytotoxicity and cell number of adoptively transferred T cells are efficiently maintained in vivo by re-stimulation with an antigen/interleukin-2 fusion protein. Int. J. Cancer. 82:569-573.
14. Kim, D.T., D.J. Mitchell, D.G. Brockstedt, L. Fong, G.P. Nolan, C.G. Fathman, E.G. Engleman, and J.B. Rothbard. 1997. Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide. J. Immunol. 159:1666-1668.
15. Barrios, C., A.R. Lussow, J. Van Embden, R. Van der Zee, R. Rappuoli, P. Constantino, J.A. Louis, P.H. Lambert, and G. Del Giudice. 1992. Mycobacterial heat-shock proteins as carrier molecules. II: The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guérin priming. Eur. J. Immunol. 22:1365-1372.
16. Suzue, K., and R.A. Young. 1996. Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. J. Immunol. 156:873-876.
17. Horwitz, M.S., L.M. Bradley, J. Harbertson, T. Krahl, J. Lee, and N. Sarvetnick. 1998. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 4:781-785.
18. Könen-Waisman, S., A. Cohen, M. Fridkin, and I.R. Cohen. 1999. Self heat-shock protein (hsp60) peptide serves in a conjugate vaccine against a lethal pneumococcal infection. J. Infect. Dis. 179:403-413.
19. Young, R.A. 1990. Stress proteins and immunology. Annu. Rev. Immunol. 8:401-420.
20. Schild, H., D. Arnold-Schild, E. Lammert, and H-G. Rammensee. 1999. Stress proteins and immunity mediated by cytotoxic T lymphocytes. Curr. Opin. Immunol. 11:109-113.
21. McReynolds, L.A., J.F. Catterall, and B.W. O'Malley. 1977. The ovalbumin gene: cloning of a complete ds-cDNA in a bacterial plasmid. Gene. 2:217-231.
22. Braciale, T.J., L.A. Morrison, M.T. Sweetser, J. Sambrook, M.J. Gething, and V.L. Braciale. 1987. Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes. Immunol. Rev. 98:95-114.
23. Jondal, M., R. Schirmbeck, and J. Reimann. 1996. MHC class I-restricted CTL responses to exogenous antigens. Immunity. 5:295-302.
24. Bennett, S.R., F.R. Carbone, F. Karamalis, R.A. Flavell, J.F. Miller, and W.R. Heath. 1998. Help for cytotoxic-T-cell respouses is mediated by CD40 signalling. Nature. 393:478-480.
25. + T-helper and a T-killer cell. Nature. 393:474-478.
26. Schoenberger, S.P., R.E. Toes, R.I. van der Voort, R. Offringa, and C.J. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 393:480-483.
27. Guerder, S., and P. Matzinger. 1992. A fail-safe mechanism for maintaining self-tolerance. J. Exp. Med. 176:553-564.
28. + T cell help J. Exp. Med. 186:65-70.
29. Bachmann, M.F., R.M. Zinkernagel, and A. Oxenius. 1988. Immune responses in the absence of costimulation: viruses know the trick. J. Immunol. 161:5791-5794.
30. Leist, T.P., S.P. Cobbold, H. Waldmann, M. Aguet, and R.M. Zinkernagel. 1987. Functional analysis of T lymphocyte subsets in antiviral host defense. J. Immunol. 138:2278-2281.
31. Ahmed, R., L.D. Butler, and L. Bhatti. 1988. T4+ T helper cell function in vivo: differential requirements for induction of antiviral cytotoxic T cell and antibody responses. J. Virol. 62:2102-2106.
32. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature. 353:180-184.
33. von Herrath, M., M. Yokoyama, J. Dockter, M.B. Oldstone, and J.L. Whitton. 1996. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J. Virol. 70:1072-1079.
34. Buller, K.M., K.L. Holmes, A. Hügin, T.N. Fredrickson, and H.C. Morse. 1987. Induction of cytotoxic T cell responses in vivo in the absence of CD4 helper cells. Nature. 328:77-79.
35. + -cell responses. Curr: Biol. 4:499-505.
36. + cells are essential for allorejection. J. Exp. Med. 184:2013-2018.
37. Hunt, C., and S. Calderwood. 1990. Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines. Gene. 87:199-204.
38. Flaherty, K.M., C. DeLuca-Flaherty, and D.B. McKay. 1990. Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature. 346:623-628.
39. Zhu, X., Z. Zhao, W.F. Burkholder, A. Gragerov, C.M. Ogata, M.E. Gottesman, and W.A. Hendrickson. 1996. Structural analysis of substrate binding by the molecular chaperone DnaK. Science. 272:1606-1614.
40. + T cells mediate CD40-independent maturation of dendritic cell; in vivo. J. Exp. Med. 189:1875-1883.
41. Chen, W., U. Syldath, K. Bellmann, V. Burkart, and H. Kolb. 1999. Human 60-kDa heat-shock protein: a danger signal to the innate immune system. J. Immunol. 162:3212-3219.
42. Kol, A., T. Bourcier, A.H. Lichtman, and P. Libby. 1990. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophage. J. Clin, Invest. 103:571-577.
43. Breloer, M., B. Fleischer, and A. von Bonin. 1999. In vivo and in vitro activation of T cells after administration of Agnegative heat shock proteins. J. Immunol. 162:3141-3147.
44. Kalams, S.A., S.P. Buchbinder, E.S. Rosenberg, J.M. Billingsley, D.S. Colbert, N.G. Jones, A.K. Shea, A.K. Trocha, and B.D. Walker. 1999. Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immuno-deficiency virus type 1 infection. J. Virol 73:6715-6720.
45. Harrer, T., E. Harrer, S.A. Kalams, T. Elbeik, S.I. Staprans, M.B. Feinberg, Y. Cao, D.D. Ho, T. Yilma, A.M. Caliendo, et al. 1996. Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection. AIDS Res. Hum. Retroviruses. 12:585-592.
46. Harrer, T., E. Harrer, S.A. Kalams, P. Barbosa, A. Trocha, R.P. Johnson, T. Elbeik, M.B. Feinberg, S.P. Buchbinder, and B.D. Walker. 1996. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J. Immunol. 156:2616-2623.
47. Yang, O.O., S.A. Kalams, M. Rosenzweig, S. Trocha, N. Jones, M. Koziel, D.D. Walker, and R.P. Johnson. 1996. Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes. J. Virol 70:5799-5806.
48. + cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. J. Virol. 71:3120-3128.
49. Matano, T., R. Shibata, C. Siemon, M. Connors, H.C. Lane, and M.A. Martin. 1998. Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques, J. Virol. 72:164-169.
50. Wagner, L., O.O. Yang, E.A. Garcia-Zepeda, Y. Ge, S.A. Kalamas, B.D. Walker, M.S. Pasternack, and A.D. Luster. 1998. Beta-chemokines are released from HIV-1-spccific cytotoxic T cell granules complexed to proteoglycans. Nature. 391:908-911.