Trypanosoma cruzi heat-shock protein-70 kDa, alone or fused to the parasite KMP11 antigen, induces functional maturation of murine dendritic cells

Immunology and Cell Biology

Volumn 80, Issue 3, 2002, Pages 241-247

  Planelles, L ^a   Thomas, Mc ^b   Pulgar, M ^a   Maranon C ^a   Grabbe, S ^c   Lopez M C ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Dendritic cell; Heat shock protein 70; Immunostimulatory effect; KMP11; Maturation; Mixed leucocyte reaction; Trypanosoma cruzi

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; HEAT SHOCK PROTEIN 70; INTERLEUKIN 12; PARASITE ANTIGEN; PARASITE ANTIGEN KMP 11; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HYBRID PROTEIN; KINETOPLASTID MEMBRANE PROTEIN 11, LEISHMANIA DONOVANI; MEMBRANE PROTEIN; POLYMYXIN B; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; IMMUNOPROPHYLAXIS; IMMUNOSTIMULATION; IMMUNOTHERAPY; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STEM CELL; ANIMAL; CELL CULTURE; DRUG EFFECT; GENETICS; HEMATOPOIETIC STEM CELL; IMMUNOLOGY; METABOLISM; MOUSE; PHYSIOLOGY; TRYPANOSOMA CRUZI;

ANIMAL; ANTIGENS, PROTOZOAN; CELLS, CULTURED; DENDRITIC CELLS; HEAT-SHOCK PROTEINS 70; HEMATOPOIETIC STEM CELLS; MEMBRANE GLYCOPROTEINS; MICE; POLYMYXIN B; PROTOZOAN PROTEINS; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; TRYPANOSOMA CRUZI; ANIMALS; HSP70 HEAT-SHOCK PROTEINS;

ANIMALIA; MURINAE; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0035989335     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.2002.01081.x     Document Type: Article

References (16)

1. Immunobiology of dendritic cells
2. Cytotoxic T lymphocyte activation by cross-priming
3. Developmental regulation of MHC class II transport in mouse dendritic cells
4. The role of heat shock proteins and their receptors in the activation of the immune system
5. Cutting edge receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
6. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways
7. The role of heat shock protein (hsp70) in dendritic cell maturation: hsp70 induces the maturation of immature dendritic cells but reduce DC differentiation from monocyte precursors
8. HSP70 from Trypanosoma cruzi is endowed with specific cell proliferation potential leading to apoptosis
9. b transgenic mice with the KMP11-HSP70 fusion protein induces CTL response against human cells expressing the T. cruzi KMP11 antigen: Identification of A2-restricted epitopes
10. DNA immunization with the T. cruzi HSP70 fused to KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection
11. CD91: A receptor for heat shock protein gp96
12. In vivo cytotoxic T lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain is CD4 (+) T cell independent
13. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
14. A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins
15. Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi
16. Heat shock proteins: Applications in health and disease