Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen

Gene Therapy

Volumn 8, Issue 5, 2001, Pages 376-383

  Hsu, K F ^a,b   Hung, C F ^a   Cheng, W F ^a,c   He, L ^a   Slater, L A ^a   Ling, M ^a   Wu, T C ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

E7; Heat shock protein; Human papillomavirus; Semliki forest virus; Suicidal DNA

Indexed keywords

ANTIBIOTIC AGENT; CD8 ANTIGEN; DNA VACCINE; HEAT SHOCK PROTEIN 70; VIRUS PROTEIN; VIRUS RNA;

ALPHA VIRUS; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL TRANSFORMATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOLYSIS; DNA VECTOR; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG STABILITY; FEMALE; FUSION GENE; GENETIC TRANSFECTION; HOST; IMMUNITY; METASTASIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SEMLIKI FOREST ALPHAVIRUS; SUICIDE GENE; VACCINATION; WART VIRUS;

ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNITY, CELLULAR; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; SEMLIKI FOREST VIRUS; VACCINATION; VACCINES, DNA;

ACTINOBACTERIA (CLASS); ALPHAVIRUS; ANIMALIA; DNA VIRUSES; HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPES; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; SEMLIKI FOREST VIRUS; UNCULTURED ACTINOMYCETE;

EID: 0035077790     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301408     Document Type: Article

References (33)

1. Nucleic acid vaccines: An overview
2. DNA vaccines
3. Cancer therapy using a self-replicating RNA vaccine
4. Enhancing immune responses using suicidal DNA vaccines
5. Enhancement of tumor-specific immune response with plasmid DNA replicon vectors
6. Rapid, high level protein production using DNA-based Semliki Forest virus vectors
7. Immunology of the human papilloma virus in relation to cancer
8. Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene
9. Generation of tumor-specific cytotoxic T lymphocytes and memory T cells by immunization with tumor-derived heat shock protein gp96
10. Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides
11. Immunization with a lymphocytic choriomeningitis virus peptide mixed with heat shock protein 70 results in protective antiviral immunity and specific cytotoxic T lymphocytes
12. Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24
13. Experimental vaccine strategies for cancer immunotherapy
14. Cancer vaccines
15. Human tumor antigens for cancer vaccine development
16. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
17. Translation of Sindbis virus mRNA: Analysis of sequences downstream of the initiating AUG condon that enhance translation
18. Heat shock proteins as carrier molecules: In vivo helper effect mediated by Escherichia coli GroEL and DnaK proteins requires cross-linking with antigen
19. Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway
20. Priming of CD8+ CTL effector cells in mice by immunization with a stress protein-influenza virus nucleoprotein fusion molecule
21. Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells
22. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
23. Cutting edge: Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
24. A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins
25. DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1
26. Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses
27. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
28. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells
29. A 'public' T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes
30. Engineering an intracellular pathway for MHC class II presentation of HPV-16 E7
31. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: Similarity of L3T4 to the human Leu-3/T4 molecule
32. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement
33. The NK-1.1(-) mouse: A model to study differentiation of murine NK cells