-
1
-
-
0036093865
-
Inflammation and the development of pancreatic cancer
-
Farrow B, Evers BM: Inflammation and the development of pancreatic cancer. Surg Oncol Oxf 2002, 10:153-169
-
(2002)
Surg Oncol Oxf
, vol.10
, pp. 153-169
-
-
Farrow, B.1
Evers, B.M.2
-
2
-
-
0028910239
-
Recent cancer trends in the United States
-
Devesa SS, Blot WJ, Stone BJ, Miller BA, Tarone RE, Fraumeni Jr JF: Recent cancer trends in the United States. J Natl Cancer Inst 1995, 87:175-182
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 175-182
-
-
Devesa, S.S.1
Blot, W.J.2
Stone, B.J.3
Miller, B.A.4
Tarone, R.E.5
Fraumeni Jr., J.F.6
-
3
-
-
0031934765
-
Role of growth factors in pancreatic cancer
-
Korc M: Role of growth factors in pancreatic cancer. Surg Oncol Clin N Am 1998, 7:25-41
-
(1998)
Surg Oncol Clin N Am
, vol.7
, pp. 25-41
-
-
Korc, M.1
-
4
-
-
0035177036
-
Growth factors and their receptors in pancreatic cancer
-
Ozawa F, Friess H, Tempia-Caliera A, Kleeff J, Buchler MW: Growth factors and their receptors in pancreatic cancer. Teratog Carcinog Mutagen 2001, 21:27-44
-
(2001)
Teratog Carcinog Mutagen
, vol.21
, pp. 27-44
-
-
Ozawa, F.1
Friess, H.2
Tempia-Caliera, A.3
Kleeff, J.4
Buchler, M.W.5
-
5
-
-
0027733796
-
K-ras oncogene activation in adenocarcinoma of the human pancreas: A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and altele-specific oligonucleotide hybridization
-
Hruban RH, van Mansfeld AD, Offerhaus GJ, van Weering DH, Allison DC, Goodman SN, Kensler TW, Bose KK, Cameron JL, Bos JL: K-ras oncogene activation In adenocarcinoma of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and altele-specific oligonucleotide hybridization. Am J Pathol 1993, 143:545-554
-
(1993)
Am J Pathol
, vol.143
, pp. 545-554
-
-
Hruban, R.H.1
Van Mansfeld, A.D.2
Offerhaus, G.J.3
Van Weering, D.H.4
Allison, D.C.5
Goodman, S.N.6
Kensler, T.W.7
Bose, K.K.8
Cameron, J.L.9
Bos, J.L.10
-
6
-
-
0026334753
-
Abnormalities of the p53 tumor suppressor gene in human pancreatic cancer
-
Barton CM, Staddon SL, Hughes CM, Hall PA, O'Sullivan C, Kloppel G, Theis B, Russell RC, Neoptolemos J, Williamson RC, Lane DP: Abnormalities of the p53 tumor suppressor gene in human pancreatic cancer. Br J Cancer 1991, 64:1076-1082
-
(1991)
Br J Cancer
, vol.64
, pp. 1076-1082
-
-
Barton, C.M.1
Staddon, S.L.2
Hughes, C.M.3
Hall, P.A.4
O'Sullivan, C.5
Kloppel, G.6
Theis, B.7
Russell, R.C.8
Neoptolemos, J.9
Williamson, R.C.10
Lane, D.P.11
-
7
-
-
0028059330
-
Frequent somatic mulations and homozygous deletions of the p16 gene in pancreatic adenocarcinoma
-
Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ, Kern SE: Frequent somatic mulations and homozygous deletions of the p16 gene in pancreatic adenocarcinoma. Nat Genet 1994, 8:27-32
-
(1994)
Nat Genet
, vol.8
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
Da Costa, L.T.3
Redston, M.S.4
Schutte, M.5
Seymour, A.B.6
Weinstein, C.L.7
Hruban, R.H.8
Yeo, C.J.9
Kern, S.E.10
-
8
-
-
0035156083
-
Transforming growth factor-β signal transduction in epithelial cells
-
Yue J, Mulder KM: Transforming growth factor-β signal transduction in epithelial cells. Pharmacol Ther 2001, 91:1-34
-
(2001)
Pharmacol Ther
, vol.91
, pp. 1-34
-
-
Yue, J.1
Mulder, K.M.2
-
9
-
-
0034644472
-
TGF-β signaling in growth control, cancer, and heritable disorders
-
Massague J, Blain SW, Lo RS: TGF-β signaling in growth control, cancer, and heritable disorders. Cell 2000, 103:295-309
-
(2000)
Cell
, vol.103
, pp. 295-309
-
-
Massague, J.1
Blain, S.W.2
Lo, R.S.3
-
10
-
-
0031685620
-
TGF-β signal transduction
-
Massague J: TGF-β signal transduction. Annu Rev Biochem 1998, 67:753-791
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 753-791
-
-
Massague, J.1
-
11
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996, 271:350-353
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
Moskaluk, C.A.4
Da Costa, L.T.5
Rozenblum, E.6
Weinstein, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
-
12
-
-
9344223357
-
DPC4 gene in various tumor types
-
Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H: DPC4 gene in various tumor types. Cancer Res 1996, 56:2527-2530
-
(1996)
Cancer Res
, vol.56
, pp. 2527-2530
-
-
Schutte, M.1
Hruban, R.H.2
Hedrick, L.3
Cho, K.R.4
Nadasdy, G.M.5
Weinstein, C.L.6
Bova, G.S.7
Isaacs, W.B.8
Cairns, P.9
Nawroz, H.10
-
13
-
-
18344366530
-
Gene therapy for pancreatic cancer based on genetic characterization of the disease
-
Sunamura M, Yatsuoka T, Motoi F, Duda DG, Kimura M, Abe T, Yokoyama T, Inoue H, Oonuma M, Takeda K, Matsuno S: Gene therapy for pancreatic cancer based on genetic characterization of the disease. J Hepatobiliary Pancreat Surg 2002, 9:32-38
-
(2002)
J Hepatobiliary Pancreat Surg
, vol.9
, pp. 32-38
-
-
Sunamura, M.1
Yatsuoka, T.2
Motoi, F.3
Duda, D.G.4
Kimura, M.5
Abe, T.6
Yokoyama, T.7
Inoue, H.8
Oonuma, M.9
Takeda, K.10
Matsuno, S.11
-
14
-
-
0035671396
-
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma
-
Tascilar M, Skinner HG, Rosty C, Sohn T, Wilentz RE, Offerhaus GJ, Adsay V, Abrams RA, Cameron JL, Kern SE, Yeo CJ, Hruban RH, Goggins M: The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin Cancer Res 2001, 7:4115-4121
-
(2001)
Clin Cancer Res
, vol.7
, pp. 4115-4121
-
-
Tascilar, M.1
Skinner, H.G.2
Rosty, C.3
Sohn, T.4
Wilentz, R.E.5
Offerhaus, G.J.6
Adsay, V.7
Abrams, R.A.8
Cameron, J.L.9
Kern, S.E.10
Yeo, C.J.11
Hruban, R.H.12
Goggins, M.13
-
15
-
-
16044369574
-
MADR2 maps to 18q21 and encodes a TGF-β-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
-
Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL: MADR2 maps to 18q21 and encodes a TGF-β-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 1996, 86:543-552
-
(1996)
Cell
, vol.86
, pp. 543-552
-
-
Eppert, K.1
Scherer, S.W.2
Ozcelik, H.3
Pirone, R.4
Hoodless, P.5
Kim, H.6
Tsui, L.C.7
Bapat, B.8
Gallinger, S.9
Andrulis, I.L.10
-
16
-
-
0030837455
-
A structural basis for mutational inactivation of the tumour suppressor Smad4
-
Shi Y, Hata A, Lo RS, Massague J, Pavletich NP: A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 1997, 388:87-93
-
(1997)
Nature
, vol.388
, pp. 87-93
-
-
Shi, Y.1
Hata, A.2
Lo, R.S.3
Massague, J.4
Pavletich, N.P.5
-
17
-
-
0034712832
-
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway
-
Xu J, Attisano L: Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 2000, 97:4820-4825
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4820-4825
-
-
Xu, J.1
Attisano, L.2
-
18
-
-
0035900731
-
Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability
-
Maurice D, Pierreux CE, Howell M, Wilentz RE, Owen MJ, Hill CS: Loss of Smad4 function in pancreatic tumors: c-terminal truncation leads to decreased stability. J Biol Chem 2001, 276:43175-43181
-
(2001)
J Biol Chem
, vol.276
, pp. 43175-43181
-
-
Maurice, D.1
Pierreux, C.E.2
Howell, M.3
Wilentz, R.E.4
Owen, M.J.5
Hill, C.S.6
-
19
-
-
0042858169
-
Differential ubiquitination defines the functional status of the tumor suppressor Smad4
-
Moren A, Hellman U, Inada Y, Imamura T, Heldinn CH, Moustakas A: Differential ubiquitination defines the functional status of the tumor suppressor Smad4. J Biol Chem 2003, 278:33571-33582
-
(2003)
J Biol Chem
, vol.278
, pp. 33571-33582
-
-
Moren, A.1
Hellman, U.2
Inada, Y.3
Imamura, T.4
Heldinn, C.H.5
Moustakas, A.6
-
20
-
-
0035895604
-
Regulation of the G1 to S transition by the ubiquitin pathway
-
DeSalle LM, Pagano M: Regulation of the G1 to S transition by the ubiquitin pathway. FEBS Lett 2001, 490:179-189
-
(2001)
FEBS Lett
, vol.490
, pp. 179-189
-
-
DeSalle, L.M.1
Pagano, M.2
-
21
-
-
0034915764
-
Mechanisms underlying ubiquitination
-
Pickart CM: Mechanisms underlying ubiquitination. Annu Rev Biochem 2001, 70:503-533
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 503-533
-
-
Pickart, C.M.1
-
22
-
-
0033279836
-
SCF and Cullin/Ring H2-based ubiquitin ligases
-
Deshaies RJ: SCF and Cullin/Ring H2-based ubiquitin ligases. Annu Rev Cell Dev Biol 1999, 15:435-467
-
(1999)
Annu Rev Cell Dev Biol
, vol.15
, pp. 435-467
-
-
Deshaies, R.J.1
-
23
-
-
0033592556
-
A family of mammalian F-box proteins
-
Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW: A family of mammalian F-box proteins. Curr Biol 1999, 9:1180-1182
-
(1999)
Curr Biol
, vol.9
, pp. 1180-1182
-
-
Winston, J.T.1
Koepp, D.M.2
Zhu, C.3
Elledge, S.J.4
Harper, J.W.5
-
24
-
-
4444318673
-
The SCF ubiquitin ligase: Insights into a molecular machine
-
Cardozo T, Pagano M: The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol 2004, 5:739-751
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 739-751
-
-
Cardozo, T.1
Pagano, M.2
-
25
-
-
17944401842
-
Identification of the receptor component of the IκBα- ubiquitin ligase
-
Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, Manning AM, Andersen JS, Mann M, Mercuric F, Ben Neriah Y: Identification of the receptor component of the IκBα-ubiquitin ligase. Nature 1998, 396:590-594
-
(1998)
Nature
, vol.396
, pp. 590-594
-
-
Yaron, A.1
Hatzubai, A.2
Davis, M.3
Lavon, I.4
Amit, S.5
Manning, A.M.6
Andersen, J.S.7
Mann, M.8
Mercuric, F.9
Ben Neriah, Y.10
-
26
-
-
0033602475
-
HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and beta-catenin
-
Fuchs SY, Chen A, Xiong Y, Pan ZQ, Ronai Z: HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and beta-catenin. Oncogene 1999, 18:2039-2046
-
(1999)
Oncogene
, vol.18
, pp. 2039-2046
-
-
Fuchs, S.Y.1
Chen, A.2
Xiong, Y.3
Pan, Z.Q.4
Ronai, Z.5
-
27
-
-
13044317276
-
Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1
-
Hatakeyama S, Kitagawa M, Nakayama M, Shirane M, Matsumoto M, Hattori K, Higashi H, Nakano H, Okumura K, Onoe K, Good RA: Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc Natl Acad Sci USA 1999, 96:3859-3863
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3859-3863
-
-
Hatakeyama, S.1
Kitagawa, M.2
Nakayama, M.3
Shirane, M.4
Matsumoto, M.5
Hattori, K.6
Higashi, H.7
Nakano, H.8
Okumura, K.9
Onoe, K.10
Good, R.A.11
-
28
-
-
0033083158
-
Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP
-
Spencer E, Jiang J, Chen ZJ: Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP. Genes Dev 1999, 13:284-294
-
(1999)
Genes Dev
, vol.13
, pp. 284-294
-
-
Spencer, E.1
Jiang, J.2
Chen, Z.J.3
-
29
-
-
0033525234
-
IκBα ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, βTrCP1 and βTrCP2
-
Suzuki H, Chiba T, Kobayashi M, Takeuchi M, Suzuki T, Ichiyama A, Ikenoue T, Omata M, Furuichi K, Tanaka K: IκBα ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, βTrCP1 and βTrCP2. Biochem Biophys Res Commun 1999, 256:127-132
-
(1999)
Biochem Biophys Res Commun
, vol.256
, pp. 127-132
-
-
Suzuki, H.1
Chiba, T.2
Kobayashi, M.3
Takeuchi, M.4
Suzuki, T.5
Ichiyama, A.6
Ikenoue, T.7
Omata, M.8
Furuichi, K.9
Tanaka, K.10
-
30
-
-
0033068154
-
The SCFβ-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IκBα ubiquitination in vitro
-
Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW: The SCFβ-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IκBα ubiquitination in vitro. Genes Dev 1999, 13:270-283
-
(1999)
Genes Dev
, vol.13
, pp. 270-283
-
-
Winston, J.T.1
Strack, P.2
Beer-Romero, P.3
Chu, C.Y.4
Elledge, S.J.5
Harper, J.W.6
-
31
-
-
0033602227
-
The F-box protein β-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
-
Hart M, Concordet JP, Lassot I, Albert I, del los Santos R, Durand H, Perret C, Rubinfeld B, Margottin F, Benarous R, Polakis P: The F-box protein β-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol 1999, 9:207-210
-
(1999)
Curr Biol
, vol.9
, pp. 207-210
-
-
Hart, M.1
Concordet, J.P.2
Lassot, I.3
Albert, I.4
Del Los Santos, R.5
Durand, H.6
Perret, C.7
Rubinfeld, B.8
Margottin, F.9
Benarous, R.10
Polakis, P.11
-
32
-
-
0033522491
-
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
-
Kitagawa M, Hatakeyama S, Shirane M, Matsumoto M, Ishida N, Hattori K, Nakamichi I, Kikuchi A, Nakayama K: An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin. EMBO J 1999, 18:2401-2410
-
(1999)
EMBO J
, vol.18
, pp. 2401-2410
-
-
Kitagawa, M.1
Hatakeyama, S.2
Shirane, M.3
Matsumoto, M.4
Ishida, N.5
Hattori, K.6
Nakamichi, I.7
Kikuchi, A.8
Nakayama, K.9
-
33
-
-
0033611567
-
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin
-
Latres E, Chiaur DS, Pagano M: The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin. Oncogene 1999, 18:849-854
-
(1999)
Oncogene
, vol.18
, pp. 849-854
-
-
Latres, E.1
Chiaur, D.S.2
Pagano, M.3
-
34
-
-
0342467925
-
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(β-TrCP) ubiquitin ligase
-
Lassot I, Segeral E, Berlioz-Torrent C, Durand H, Groussin L, Hai T, Benarous R, Margottin-Goguet F: ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(β-TrCP) ubiquitin ligase. Mol Cell Biol 2001, 21:2192-2202
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2192-2202
-
-
Lassot, I.1
Segeral, E.2
Berlioz-Torrent, C.3
Durand, H.4
Groussin, L.5
Hai, T.6
Benarous, R.7
Margottin-Goguet, F.8
-
35
-
-
0038243172
-
Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo
-
Guardavaccaro D, Kudo Y, Boulaire J, Barchi M, Busino L, Donzelli M, Margottin-Goguet F, Jackson PK, Yamasaki L, Pagano M: Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo. Dev Cell 2003, 4:799-812
-
(2003)
Dev Cell
, vol.4
, pp. 799-812
-
-
Guardavaccaro, D.1
Kudo, Y.2
Boulaire, J.3
Barchi, M.4
Busino, L.5
Donzelli, M.6
Margottin-Goguet, F.7
Jackson, P.K.8
Yamasaki, L.9
Pagano, M.10
-
37
-
-
0037151118
-
Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-κB2/p100
-
Fong A, Sun SC: Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-κB2/p100. J Biol Chem 2002, 277:22111-22114
-
(2002)
J Biol Chem
, vol.277
, pp. 22111-22114
-
-
Fong, A.1
Sun, S.C.2
-
38
-
-
0037207474
-
βTrCP-mediated proteolysis of NF-κB p105 requires phosphorylation of p105 serines 927 and 932
-
Lang V, Janzen J, Fischer GZ, Soneji Y, Beinke S, Salmeron A, Allen H, Hay RT, Ben Neriah Y, Ley SC: βTrCP-mediated proteolysis of NF-κB p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol 2003, 23:402-413
-
(2003)
Mol Cell Biol
, vol.23
, pp. 402-413
-
-
Lang, V.1
Janzen, J.2
Fischer, G.Z.3
Soneji, Y.4
Beinke, S.5
Salmeron, A.6
Allen, H.7
Hay, R.T.8
Ben Neriah, Y.9
Ley, S.C.10
-
39
-
-
0142149094
-
Regulation of the discs large tumor suppressor by a phosphorylation- dependent interaction with the β-TrCP ubiquitin ligase receptor
-
Mantovani F, Banks L: Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the β-TrCP ubiquitin ligase receptor. J Biol Chem 2003, 278:42477-42486
-
(2003)
J Biol Chem
, vol.278
, pp. 42477-42486
-
-
Mantovani, F.1
Banks, L.2
-
40
-
-
0142105396
-
SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor
-
Kumar KG, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs SY: SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J 2003, 22:5480-5490
-
(2003)
EMBO J
, vol.22
, pp. 5480-5490
-
-
Kumar, K.G.1
Tang, W.2
Ravindranath, A.K.3
Clark, W.A.4
Croze, E.5
Fuchs, S.Y.6
-
41
-
-
0242497228
-
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage
-
Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF: Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 2003, 426:87-91
-
(2003)
Nature
, vol.426
, pp. 87-91
-
-
Busino, L.1
Donzelli, M.2
Chiesa, M.3
Guardavaccaro, D.4
Ganoth, D.5
Dorrello, N.V.6
Hershko, A.7
Pagano, M.8
Draetta, G.F.9
-
42
-
-
0347361537
-
β-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
-
β-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev 2003, 17:3062-3074
-
(2003)
Genes Dev
, vol.17
, pp. 3062-3074
-
-
Jin, J.1
Shirogane, T.2
Xu, L.3
Nalepa, G.4
Qin, J.5
Elledge, S.J.6
Harper, J.W.7
-
43
-
-
1842428734
-
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP
-
Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H: M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP. Proc Natl Acad Sci USA 2004, 101:4419-4424
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4419-4424
-
-
Watanabe, N.1
Arai, H.2
Nishihara, Y.3
Taniguchi, M.4
Watanabe, N.5
Hunter, T.6
Osada, H.7
-
45
-
-
5444269904
-
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
-
Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC: Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 2004, 6:931-940
-
(2004)
Nat Cell Biol
, vol.6
, pp. 931-940
-
-
Zhou, B.P.1
Deng, J.2
Xia, W.3
Xu, J.4
Li, Y.M.5
Gunduz, M.6
Hung, M.C.7
-
46
-
-
2442492933
-
β-TrCP1
-
β-TrCP1. J Biol Chem 2004, 279:14484-14487
-
(2004)
J Biol Chem
, vol.279
, pp. 14484-14487
-
-
Wan, M.1
Tang, Y.2
Tytler, E.M.3
Lu, C.4
Jin, B.5
Vickers, S.M.6
Yang, L.7
Shi, X.8
Cao, X.9
-
47
-
-
0037117550
-
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
-
Sui G, Soohoo C, Affar EB, Gay F, Shi Y, Forrester WC, Shi Y: A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA 2002, 99:5515-5520
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 5515-5520
-
-
Sui, G.1
Soohoo, C.2
Affar, E.B.3
Gay, F.4
Shi, Y.5
Forrester, W.C.6
Shi, Y.7
-
48
-
-
0037440667
-
Expression of IGF-1 splice variants in young and old human skeletal muscle after high resistance exercise
-
Hameed M, Orrell RW, Cobbold M, Goldspink G, Harridge SD: Expression of IGF-1 splice variants in young and old human skeletal muscle after high resistance exercise. J Physiol 2003, 547:247-254
-
(2003)
J Physiol
, vol.547
, pp. 247-254
-
-
Hameed, M.1
Orrell, R.W.2
Cobbold, M.3
Goldspink, G.4
Harridge, S.D.5
-
49
-
-
0023130372
-
Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
-
Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB: Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987, 47:936-942
-
(1987)
Cancer Res
, vol.47
, pp. 936-942
-
-
Carmichael, J.1
DeGraff, W.G.2
Gazdar, A.F.3
Minna, J.D.4
Mitchell, J.B.5
-
50
-
-
0032189348
-
Proteasome inhibitors: Valuable new tools for cell biologists
-
Lee DH, Goldberg AL: Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol 1998, 8:397-403
-
(1998)
Trends Cell Biol
, vol.8
, pp. 397-403
-
-
Lee, D.H.1
Goldberg, A.L.2
-
51
-
-
1842855206
-
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells
-
De Bosscher K, Hill CS, Nicolas FJ: Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. Biochem J 2004, 379:209-216
-
(2004)
Biochem J
, vol.379
, pp. 209-216
-
-
De Bosscher, K.1
Hill, C.S.2
Nicolas, F.J.3
-
52
-
-
0032014216
-
Human SmadS and Smad4 are sequence-specific transcription activators
-
Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, Kern SE: Human SmadS and Smad4 are sequence-specific transcription activators. Mol Cell 1998, 1:611-617
-
(1998)
Mol Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
Kern, S.E.7
-
53
-
-
0034596993
-
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(lnk4B) transcription in response to TGF-β
-
Feng XH, Lin X, Derynck R: Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(lnk4B) transcription in response to TGF-β. EMBO J 2000, 19:5178-5193
-
(2000)
EMBO J
, vol.19
, pp. 5178-5193
-
-
Feng, X.H.1
Lin, X.2
Derynck, R.3
-
54
-
-
0032615068
-
TGFβ-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression
-
Voss M, Wolff B, Savitskaia N, Ungefroren H, Deppert W, Schmiegel W, Kalthoff H, Naumann M: TGFβ-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression. Int J Oncol 1999, 14:93-101
-
(1999)
Int J Oncol
, vol.14
, pp. 93-101
-
-
Voss, M.1
Wolff, B.2
Savitskaia, N.3
Ungefroren, H.4
Deppert, W.5
Schmiegel, W.6
Kalthoff, H.7
Naumann, M.8
-
55
-
-
0036848885
-
Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/ DPC4 in human pancreatic cancer cells
-
Peng B, Fleming JB, Breslin T, Grau AM, Fojioka S, Abbruzzese JL, Evans DB, Ayers D, Wathen K, Wu T, Robertson KD, Chiao PJ: Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/ DPC4 in human pancreatic cancer cells. Clin Cancer Res 2002, 8:3628-3638
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3628-3638
-
-
Peng, B.1
Fleming, J.B.2
Breslin, T.3
Grau, A.M.4
Fojioka, S.5
Abbruzzese, J.L.6
Evans, D.B.7
Ayers, D.8
Wathen, K.9
Wu, T.10
Robertson, K.D.11
Chiao, P.J.12
-
56
-
-
11144356448
-
Proteomic analysis of the TGF-β signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression
-
Imamura T, Kanai F, Kawakami T, Amarsanaa J, Ijichi H, Hoshida Y, Tanaka Y, Ikenoue T, Tateishi K, Kawabe T, Arakawa Y, Miyagishi M, Taira K, Yokosuka O, Omata M: Proteomic analysis of the TGF-β signaling pathway in pancreatic carcinoma cells using stable RNA interference to silence Smad4 expression. Biochem Biophys Res Commun 2004, 318:289-296
-
(2004)
Biochem Biophys Res Commun
, vol.318
, pp. 289-296
-
-
Imamura, T.1
Kanai, F.2
Kawakami, T.3
Amarsanaa, J.4
Ijichi, H.5
Hoshida, Y.6
Tanaka, Y.7
Ikenoue, T.8
Tateishi, K.9
Kawabe, T.10
Arakawa, Y.11
Miyagishi, M.12
Taira, K.13
Yokosuka, O.14
Omata, M.15
-
57
-
-
10744224876
-
Smad4-independent regulation of p21/WAF1 by transforming growth factor-β
-
Ijichi H, Otsuka M, Tateishi K, Ikenoue T, Kawakami T, Kanai F, Arakawa Y, Seki N, Shimizu K, Miyazono K, Kawabe T, Omata M: Smad4-independent regulation of p21/WAF1 by transforming growth factor-β. Oncogene 2004, 23:1043-1051
-
(2004)
Oncogene
, vol.23
, pp. 1043-1051
-
-
Ijichi, H.1
Otsuka, M.2
Tateishi, K.3
Ikenoue, T.4
Kawakami, T.5
Kanai, F.6
Arakawa, Y.7
Seki, N.8
Shimizu, K.9
Miyazono, K.10
Kawabe, T.11
Omata, M.12
-
58
-
-
1842481404
-
Missense mutations of MADH4: Characterization of the mutational hot spot and functional consequences in human tumors
-
Iacobuzio-Donahue CA, Song J, Parmiagiani G, Yeo CJ, Hruban RH, Kern SE: Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors. Clin Cancer Res 2004, 10:1597-1604
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1597-1604
-
-
Iacobuzio-Donahue, C.A.1
Song, J.2
Parmiagiani, G.3
Yeo, C.J.4
Hruban, R.H.5
Kern, S.E.6
-
59
-
-
0030837455
-
A structural basis for mutational inactivalion of the tumour suppressor Smad4
-
Shi Y, Hata A, Lo RS, Massague J, Pavletich NP: A structural basis for mutational inactivalion of the tumour suppressor Smad4. Nature 1997, 388:87-93
-
(1997)
Nature
, vol.388
, pp. 87-93
-
-
Shi, Y.1
Hata, A.2
Lo, R.S.3
Massague, J.4
Pavletich, N.P.5
-
60
-
-
16044369574
-
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
-
Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL. Attisano L: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 1996, 86:543-552
-
(1996)
Cell
, vol.86
, pp. 543-552
-
-
Eppert, K.1
Scherer, S.W.2
Ozcelik, H.3
Pirone, R.4
Hoodless, P.5
Kim, H.6
Tsui, L.C.7
Bapat, B.8
Gallinger, S.9
Andrulis, I.L.10
Thomsen, G.H.11
Wrana, J.L.12
Attisano, L.13
-
61
-
-
0034695590
-
The Smad4 activation domain (SAD) is a praline-rich, p300-dependent transcriptional activation domain
-
de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB, Lechieider RJ: The Smad4 activation domain (SAD) is a praline-rich, p300-dependent transcriptional activation domain. J Biol Chem 2000, 275:2115-2122
-
(2000)
J Biol Chem
, vol.275
, pp. 2115-2122
-
-
De Caestecker, M.P.1
Yahata, T.2
Wang, D.3
Parks, W.T.4
Huang, S.5
Hill, C.S.6
Shioda, T.7
Roberts, A.B.8
Lechieider, R.J.9
-
62
-
-
0034618406
-
Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4
-
Moren A, Itoh S, Moustakas A, Dijke P, Heldin CH: Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4. Oncogene 2000, 19:4396-4404
-
(2000)
Oncogene
, vol.19
, pp. 4396-4404
-
-
Moren, A.1
Itoh, S.2
Moustakas, A.3
Dijke, P.4
Heldin, C.H.5
-
63
-
-
0033532057
-
Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling
-
Shi X, Yang X, Chen D, Chang Z, Cao X: Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. J Biol Chem 1999, 274:13711-13717
-
(1999)
J Biol Chem
, vol.274
, pp. 13711-13717
-
-
Shi, X.1
Yang, X.2
Chen, D.3
Chang, Z.4
Cao, X.5
-
64
-
-
0035808495
-
Hoxa-9 represses transforming growth factor-beta-induced osteopontin gene transcription
-
Shi X, Bai S, Li L, Cao X: Hoxa-9 represses transforming growth factor-beta-induced osteopontin gene transcription. J Biol Chem 2001, 276:850-855
-
(2001)
J Biol Chem
, vol.276
, pp. 850-855
-
-
Shi, X.1
Bai, S.2
Li, L.3
Cao, X.4
-
65
-
-
0038012730
-
Smad4 as a transcription compressor for estrogen receptor alpha
-
Wu L, Wu Y, Gathings B, Wan M, Li X, Grizzle W, Liu Z, Lu C, Mao Z. Cao X: Smad4 as a transcription compressor for estrogen receptor alpha. J Biol Chem 2003, 278:15192-15200
-
(2003)
J Biol Chem
, vol.278
, pp. 15192-15200
-
-
Wu, L.1
Wu, Y.2
Gathings, B.3
Wan, M.4
Li, X.5
Grizzle, W.6
Liu, Z.7
Lu, C.8
Mao, Z.9
Cao, X.10
-
66
-
-
0033536001
-
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
-
Shimizu K, Surdon JBA: A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation. Proc Natl Acad Sci USA 1996, 96:6791-6796
-
(1996)
Proc Natl Acad Sci USA
, vol.96
, pp. 6791-6796
-
-
Shimizu, K.1
Surdon, J.B.A.2
|