Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

Journal of Biological Chemistry

Volumn 276, Issue 46, 2001, Pages 43175-43181

  Maurice, Diane ^a   Pierreux, Christophe E ^a,c   Howell, Michael ^a   Wilentz, Robb E ^b   Owen, Michael J ^a,d   Hill, Caroline S ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; DNA; TUMORS;

TRANSCRIPTION PATHWAY;

BIOCHEMISTRY;

DNA; PROTEASOME; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN; AMINO ACID; CYCLOHEXIMIDE; DNA BINDING PROTEIN; MESSENGER RNA; PROTEIN SYNTHESIS INHIBITOR; RIBONUCLEASE; SMAD2 PROTEIN, HUMAN; SMAD2 PROTEIN, MOUSE; SMAD2 PROTEIN, XENOPUS; SMAD4 PROTEIN, HUMAN; SMAD4 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; XENOPUS PROTEIN; XSMAD4A PROTEIN, XENOPUS; XSMAD4B PROTEIN, XENOPUS;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; COMPLEX FORMATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOLECULAR MODEL; MOUSE; NONHUMAN; NONSENSE MUTATION; PANCREAS ADENOCARCINOMA; PANCREAS TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; ADENOCARCINOMA; ALLELE; ANIMAL; CELL LINE; CELL STRAIN 3T3; CHEMICAL STRUCTURE; CHEMISTRY; CODON; DOMINANT GENE; GENETIC TRANSCRIPTION; GENETICS; HETEROZYGOSITY LOSS; MESODERM; METABOLISM; MUTATION; PLASMID; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; STOP CODON; TIME; WESTERN BLOTTING; XENOPUS;

ANIMALIA;

3T3 CELLS; ADENOCARCINOMA; ALLELES; AMINO ACIDS; ANIMALS; BLOTTING, WESTERN; CELL LINE; CODON; CODON, NONSENSE; CYCLOHEXIMIDE; DNA-BINDING PROTEINS; GENES, DOMINANT; HUMANS; LOSS OF HETEROZYGOSITY; MESODERM; MICE; MODELS, MOLECULAR; MUTATION; PANCREATIC NEOPLASMS; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SYNTHESIS INHIBITORS; RIBONUCLEASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD4 PROTEIN; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; XENOPUS; XENOPUS PROTEINS;

EID: 0035900731     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105895200     Document Type: Article

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