Negative Regulation of Prolactin Receptor Stability and Signaling Mediated by SCFβ-TrCP E3 Ubiquitin Ligase

Molecular and Cellular Biology

Volumn 24, Issue 9, 2004, Pages 4038-4048

  Li, Ying ^a   Kumar, K G Suresh ^a   Tang, Weigang ^a   Spiegelman, Vladimir S ^b   Fuchs, Serge Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

F BOX PROTEIN; HORMONE RECEPTOR; MUTANT PROTEIN; PROLACTIN; PROLACTIN RECEPTOR; PROTEIN BETA TRCP2; PROTEIN SUBUNIT; SCF BETA TRCP E3 UBIQUITIN LIGASE; SERINE; STAT5 PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE ACTIVATION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UBIQUITINATION; WILD TYPE;

AMINO ACID MOTIFS; ANIMALS; CELL LINE; CRICETINAE; HUMANS; MICE; PHOSPHORYLATION; PROLACTIN; RECEPTORS, PROLACTIN; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN;

ANIMALIA;

EID: 1942453784     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.9.4038-4048.2004     Document Type: Article

References (55)

1. Ben-Jonathan, N., K. Liby, M. McFarland, and M. Zinger. 2002. Prolactin as an autocrine/paracrine growth factor in human cancer. Trends Endocrinol. Metab. 13:245-250.
2. Bole-Feysot, C., V. Goffin, M. Edery, N. Binart, and P. A. Kelly. 1998. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr. Rev. 19:225-268.
3. Busino, L., M. Donzelli, M. Chiesa, D. Guardavaccaro, D. Ganoth, N. V. Dorrello, A. Hershko, M. Pagano, and G. F. Draetta. 2003. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 426:87-91.
4. Cenciarelli, C., D. S. Chiaur, D. Guardavaccaro, W. Parks, M. Vidal, and M. Pagano. 1999. Identification of a family of human F-box proteins. Curr. Biol. 9:1177-1179.
5. Clevenger, C. V., D. O. Freier, and J. B. Kline. 1998. Prolactin receptor signal transduction in cells of the immune system. J. Endocrinol. 157:187-197.
6. Clevenger, C. V., P. A. Furth, S. E. Hankinson, and L. A. Schuler. 2003. The role of prolactin in mammary carcinoma. Endocr. Rev. 24:1-27.
7. Clevenger, C. V., and J. B. Kline. 2001. Prolactin receptor signal transduction. Lupus 10:706-718.
8. Clevenger, C. V., and T. L. Plank. 1997. Prolactin as an autocrine/paracrine factor in breast tissue. J. Mammary Gland Biol. Neoplasia 2:59-68.
9. Davis, M., A. Hatzubai, J. S. Andersen, E. Ben-Shushan, G. Z. Fisher, A. Yaron, A. Bauskin, F. Mercurio, M. Mann, and Y. Ben-Neriah. 2002. Pseudosubstrate regulation of the SCFβ-TrCP ubiquitin ligase by hnRNP-U. Genes Dev. 16:439-451.
10. Deshaies, R. J. 1999. SCF and Cullin/Ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15:435-467.
11. Djiane, J., H. Clauser, and P. A. Kelly. 1979. Rapid down-regulation of prolactin receptors in mammary gland and liver. Biochem. Biophys. Res. Commun. 90:1371-1378.
12. Djiane, J., C. Delouis, and P. A. Kelly. 1982. Prolactin receptor turnover in explants of pseudopregnant rabbit mammary gland. Mol. Cell. Endocrinol. 25:163-170.
13. Djiane, J., L. M. Houdebine, and P. A. Kelly. 1981. Down-regulation of prolactin receptors in rabbit mammary gland: differential subcellular localization. Proc. Soc. Exp. Biol. Med. 168:378-381.
14. Djiane, J., P. A. Kelly, and L. M. Houdebine. 1980. Effects of lysosomotropic agents, cytochalasin B and colchicine on the " down-regulation" of prolactin receptors in mammary gland explants. Mol. Cell. Endocrinol. 18:87-98.
15. Freeman, M. E., B. Kanyicska, A. Lerant, and G. Nagy. 2000. Prolactin: structure, function, and regulation of secretion. Physiol. Rev. 80:1523-1631.
16. Fuchs, S. Y., A. Chen, Y. Xiong, Z. Q. Pan, and Z. Ronai. 1999. HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and beta-catenin. Oncogene 18:2039-2046.
17. Genty, N., J. Paly, M. Edery, P. A. Kelly, J. Djiane, and R. Salesse. 1994. Endocytosis and degradation of prolactin and its receptor in Chinese hamster ovary cells stably transfected with prolactin receptor cDNA. Mol. Cell. Endocrinol. 99:221-228.
18. Goffin, V., N. Binart, P. Touraine, and P. A. Kelly. 2002. Prolactin: the new biology of an old hormone. Annu. Rev. Physiol. 64:47-67.
19. Gourdou, I., J. Paly, C. Hue-Beauvais, L. Pessemesse, J. Clark, and J. Djiane. 2004. Expression by transgenesis of a constitutively active mutant form of the prolactin receptor induces premature abnormal development of the mouse mammary gland and lactation failure. Biol. Reprod. 70:718-728.
20. Govers, R., P. van Kerkhof, A. L. Schwartz, and G. J. Strous. 1998. Dileucine-mediated internalization of ligand by a truncated growth hormone receptor is independent of the ubiquitin conjugation system. J. Biol. Chem. 273:16426-16433.
21. Guardavaccaro, D., Y. Kudo, J. Boulaire, M. Barchi, L. Busino, M. Donzelli, F. Margottin-Goguet, P. K. Jackson, L. Yamasaki, and M. Pagano. 2003. Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev. Cell 4:799-812.
22. Hart, M., J. P. Concordet, I. Lassot, I. Albert, R. del los Santos, H. Durand, C. Perret, B. Rubinfeld, F. Margottin, R. Benarous, and P. Polakis. 1999. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr. Biol. 9:207-210.
23. Hatakeyama, S., M. Kitagawa, K. Nakayama, M. Shirane, M. Matsumoto, K. Hattori, H. Higashi, H. Nakano, K. Okumura, K. Onoe, and R. A. Good. 1999. Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. Proc. Natl. Acad. Sci. USA 96:3859-3863.
24. Heller, R. A., K. Song, N. Fan, and D. J. Chang. 1992. The p70 tumor necrosis factor receptor mediates cytotoxicity. Cell 70:47-56.
25. Hicke, L. 1999. Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels. Trends Cell Biol. 9:107-112.
26. Hicke, L. 2001. Protein regulation by monoubiquitin. Nat. Rev. Mol. Cell Biol. 2:195-201.
27. Hicke, L., and R. Dunn. 2003. Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu. Rev. Cell Dev. Biol. 19:141-172.
28. βTRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev. 17:3062-3074.
29. Kitagawa, M., S. Hatakeyama, M. Shirane, M. Matsumoto, N. Ishida, K. Hattori, I. Nakamichi, A. Kikuchi, and K. Nakayama. 1999. An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J. 18:2401-2410.
30. Kline, J. B., H. Roehrs, and C. V. Clevenger. 1999. Functional characterization of the intermediate isoform of the human prolactin receptor. J. Biol. Chem. 274:35461-35468.
31. Kline, J. B., M. A. Rycyzyn, and C. V. Clevenger. 2002. Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domain. Mol. Endocrinol. 16:2310-2322.
32. Kumar, K. G., W. Tang, A. K. Ravindranath, W. A. Clark, E. Croze, and S. Y. Fuchs. 2003. SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J. 22:5480-5490.
33. βTrCP ubiquitin ligase. Mol. Cell. Biol. 21:2192-2202.
34. Latres, E., D. S. Chiaur, and M. Pagano. 1999. The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene 18:849-854.
35. Lee, R. C., J. A. Walters, M. E. Reyland, and S. M. Anderson. 1999. Constitutive activation of the prolactin receptor results in the induction of growth factor-independent proliferation and constitutive activation of signaling molecules. J. Biol. Chem. 274:10024-10034.
36. Levkowitz, G., H. Waterman, E. Zamir, Z. Kam, S. Oved, W. Y. Langdon, L. Beguinot, B. Geiger, and Y. Yarden. 1998. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev. 12:3663-3674.
37. Lu, J. C., P. Scott, G. J. Strous, and L. A. Schuler. 2002. Multiple internalization motifs differentially used by prolactin receptor isoforms mediate similar endocytic pathways. Mol. Endocrinol. 16:2515-2527.
38. Mantovani, F., and L. Banks. 2003. Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the β-TrCP ubiquitin ligase receptor. J. Biol. Chem. 278:42477-42486.
39. Margottin, F., S. P. Bour, H. Durand, L. Selig, S. Benichou, V. Richard, D. Thomas, K. Strebel, and R. Benarous. 1998. A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol. Cell 1:565-574.
40. βTrCP/Slimb ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev. Cell 4:813-826.
41. Root, A. W. 1976. Growth hormone and prolactin in the fetus. Prog. Clin. Biol. Res. 10:107-126.
42. Ross, R. J., N. Esposito, X. Y. Shen, S. Von Laue, S. L. Chew, P. R. Dobson, M. C. Postel-Vinay, and J. Finidori. 1997. A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein. Mol. Endocrinol. 11:265-273.
43. Sotiropoulos, A., S. Moutoussamy, F. Renaudie, M. Clauss, C. Kayser, F. Gouilleux, P. A. Kelly, and J. Finidori. 1996. Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor. Mol. Endocrinol. 10:998-1009.
44. Spencer, E., J. Jiang, and Z. J. Chen. 1999. Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP. Genes Dev. 13:284-294.
45. Spiegelman, V. S., W. Tang, M. Katoh, T. J. Slaga, and S. Y. Fuchs. 2002. Inhibition of HOS expression and activities by Wnt pathway. Oncogene 21:856-860.
46. Strous, G. J., and J. Gent. 2002. Dimerization, ubiquitylation and endocytosis go together in growth hormone receptor function. FEBS Lett. 529:102-109.
47. Strous, G. J., and P. van Kerkhof. 2002. The ubiquitin-proteasome pathway and the regulation of growth hormone receptor availability. Mol. Cell. Endocrinol. 197:143-151.
48. Suzuki, H., T. Chiba, M. Kobayashi, M. Takeuchi, T. Suzuki, A. Ichiyama, T. Ikenoue, M. Omata, K. Furuichi, and K. Tanaka. 1999. IκBα ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, βTrCP1 and βTrCP2. Biochem. Biophys. Res. Commun. 256:127-132.
49. Tan, P., S. Y. Fuchs, A. Chen, K. Wu, C. Gomez, Z. Ronai, and Z. Q. Pan. 1999. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of IκBα. Mol. Cell 3:527-533.
50. Treier, M., L. M. Staszewski, and D. Bohmann. 1994. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78:787-798.
51. Vincent, V., V. Goffin, M. Rozakis-Adcock, J. P. Mornon, and P. A. Kelly. 1997. Identification of cytoplasmic motifs required for short prolactin receptor internalization. J. Biol. Chem. 272:7062-7068.
52. Weissman, A. M. 2001. Themes and variations on ubiquitylation. Nat. Rev. Mol. Cell Biol. 2:169-178.
53. Winston, J. T., D. M. Koepp, C. Zhu, S. J. Elledge, and J. W. Harper. 1999. A family of mammalian F-box proteins. Curr. Biol. 9:1180-1182.
54. β-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro. Genes Dev. 13:270-283.
55. Yaron, A., A. Hatzubai, M. Davis, I. Lavon, S. Amit, A. M. Manning, J. S. Andersen, M. Mann, F. Mercurio, and Y. Ben-Neriah. 1998. Identification of the receptor component of the IκBα-ubiquitin ligase. Nature 396:590-594.