Novel cyclopropyl β-amino acid analogues of pregabalin and gabapentin that target the α2-δ protein

Journal of Medicinal Chemistry

Volumn 48, Issue 8, 2005, Pages 3026-3035

  Schwarz, Jacob B ^a   Gibbons, Sian E ^a   Graham, Shelley R ^a   Colbry, Norman L ^a   Guzzo, Peter R ^b   Le, Van Duc ^b   Vartanian, Mark G ^a   Kinsora, Jack J ^a   Lotarski, Susan M ^a   Li, Zheng ^a   Dickerson, Melvin R ^a   Su, Ti Zhi ^a   Weber, Mark L ^a   El Kattan, Ayman ^a   Thorpe, Andrew J ^a   Donevan, Sean D ^a   Taylor, Charles P ^a   Wustrow, David J ^a  

^a PFIZER INC   (United States)

^b ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOMETHYLSPIRO[2.5]OCTANE 1 CARBOXYLIC ACID; ALPHA2 DELTA PROTEIN; AMPHOLYTE; BETA AMINO ACID; CYCLOPROPYL AMINO ACID; CYCLOPROPYL BETA AMINO ACID DERIVATIVE; ESTER; GABAPENTIN; KETONE; LEUCINE; NEUTRAL AMINO ACID; NITROALKANE; PREGABALIN; PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CYCLOPROPANATION; IN VIVO STUDY; KNOEVENAGEL CONDENSATION; PROTEIN INTERACTION; PROTEIN TARGETING;

ADMINISTRATION, ORAL; AMINES; AMINO ACID TRANSPORT SYSTEM L; AMINO ACIDS; ANIMALS; ANTICONVULSANTS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; CALCIUM CHANNELS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIZATION; CYCLOHEXANECARBOXYLIC ACIDS; CYCLOPROPANES; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, INTRAVENTRICULAR; ION CHANNEL GATING; MALE; MICE; MICE, INBRED DBA; NITRILES; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; SWINE;

EID: 20944435741     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0491086     Document Type: Article

References (33)

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