Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the α2δ -1 subunit of voltage gated calcium channel

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 10, 2004, Pages 2463-2467

  Lebsack, Alec D ^a   Gunzner, Janet ^a   Wang, Bowei ^a   Pracitto, Richard ^a   Schaffhauser, Hervé ^a   Santini, Angelina ^a   Aiyar, Jayashree ^a   Bezverkov, Robert ^a   Munoz, Benito ^a   Liu, Wensheng ^a   Venkatraman, Shankar ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GABAPENTIN; TRIAZOLE DERIVATIVE; VOLTAGE GATED CALCIUM CHANNEL;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; IC 50; LIGAND BINDING; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMINES; ANALGESICS; BINDING SITES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; PHTHALAZINES; RADIOLIGAND ASSAY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11144356505     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.008     Document Type: Article

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