N-Acridin-9-yl-butane-1,4-diamine derivatives: High-affinity ligands of the α2δ subunit of voltage gated calcium channels

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 8, 2004, Pages 1913-1916

  Lim, Jongwon ^a   Stock, Nicholas ^a   Pracitto, Richard ^a   Boueres, Julia K ^a   Munoz, Benito ^a   Chaudhary, Ashok ^a   Santini, Angelina M ^a   Orr, Karia ^a   Schaffhauser, Hervé ^a   Bezverkov, Robert E ^a   Aiyar, Jayashree ^a   Venkatraman, Shankar ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE DERIVATIVE; DIAMINE DERIVATIVE; GABAPENTIN; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG IDENTIFICATION; DRUG POTENCY; HUMAN; IC 50; LIGAND BINDING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETIC ACIDS; AMINES; BINDING, COMPETITIVE; CALCIUM CHANNELS; CYCLOHEXANECARBOXYLIC ACIDS; DIAMINES; GAMMA-AMINOBUTYRIC ACID; LIGANDS; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN SUBUNITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12144289065     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.087     Document Type: Article

References (12)

1. Taylor C.P. The role of gabapentin. Chadwick D. New Trends in Epilepsy Management. 1993;13-40 Royal Society of Medicine Services Ltd, London.
2. Rosner H., Rubin L., Kestenbaum A. Clin. J. Pain. 12:1996;56.
3. Singh L., Field M.J., Ferris P., Hunter J.C., Oles R.J., Williams R.G. Psychopharmacology (Berlin). 127:1996;1.
4. Backonja M., Glanzman R.L. Clin. Ther. 25:2003;81.
5. Field M.J., Hughes J., Singh L. Br. J. Pharmacol. 131:2000;282.
6. Gee N.S., Brown J.P., Dissanayake V.U.K., Offord J., Thurlow R., Woodruff G.N. J. Biol. Chem. 271:1996;5768.
7. 3H]Gabapentin binding assay in human brain membrane (A710 membrane) was adopted from the method in the literature: Suman-Chauhan N., Webdale L., Hill D.R., Woodruff G.N. Eur. J. Pharmacol., Mol. Pharmacol. Sect. 244:1993;293.
8. Topal M.D. Biochemistry. 23:1984;2367.
9. Cain B.F., Seelye R.N., Atwell G.J. J. Med. Chem. 17:1974;922.
10. Spino C., Barriault N. J. Org. Chem. 64:1999;5292.
11. Phanstiel O. IV, Price H.L., Wang L., Juusola J., Kline M., Shah S.M. J. Org. Chem. 65:2000;5590.
12. Wolfe J.P., Tomori H., Sadighi J.P., Yin J., Buchwald S.L. J. Org. Chem. 65:2000;1158.