Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives as high-affinity ligands of the α2δ subunit of voltage-gated calcium channels

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 9, 2004, Pages 2031-2034

  Hu, Tao ^a   Stearns, Brian A ^a   Campbell, Brian T ^a   Arruda, Jeannie M ^a   Chen, Chixu ^a   Aiyar, Jayashree ^a   Bezverkov, Robert E ^a   Santini, Angelina ^a   Schaffhauser, Hervé ^a   Liu, Wensheng ^a   Venkatraman, Shankar ^a   Munoz, Benito ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Affinity; Gabapentin; SAR

Indexed keywords

ANTICONVULSIVE AGENT; GABAPENTIN; LIGAND; PROTEIN SUBUNIT; PYRIDAZINE DERIVATIVE; TRITIUM; VOLTAGE GATED CALCIUM CHANNEL;

ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; LIGAND BINDING; STRUCTURE ACTIVITY RELATION;

CALCIUM CHANNELS; DRUG EVALUATION, PRECLINICAL; ION CHANNEL GATING; LIGANDS; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11144356181     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.070     Document Type: Article

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