Differential role for Sp1/Sp3 transcription factors in the regulation of the promoter activity of multiple cyclin-dependent kinase inhibitor genes

Journal of Cellular Biochemistry

Volumn 76, Issue 3, 2000, Pages 360-367

  Pagliuca, Alfredo ^a   Gallo, Pasquale ^a   Lania, Luigi ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

CDKI regulation; CG box; Sp1 Sp3 proteins; Transcription regulation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P15; PROTEIN P16; PROTEIN P21; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3;

ARTICLE; BINDING SITE; GENE ACTIVATION; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SEQUENCE; GENE TARGETING; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0033960283     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(20000301)76:3<360::AID-JCB3>3.0.CO;2-1     Document Type: Article

References (27)

1. Adnane J, Bizouarn FA, Qian Y, Hamilton AD, Sebti SM. 1998. p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA. Mol Cell Biol 18:6962-6970.
2. Biggs JR, Kudlow JE, Kraft AS. 1996. The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells. J Biol Chem 271:901-906.
3. Birnbaum MJ, van Wijnen AJ, Odgren PR, Last TJ, Suske G, Stein GS, Stein JL. 1995. Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3. Biochemistry 34:16503-16508.
4. Brandeis M, Frank D, Keshet I, Siegfried Z, Mendelsohn M, Nemes A, Temper V, Razin A, Cedar H. 1994. Sp1 elements protect a CpG island from de novo methylation. Nature 371:435-438.
5. Datto MB, Yu Y, Wang XF. 1995. Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter. J Biol Chem 270:28623-28628.
6. Drexler HG. 1998. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia 12:845-859.
7. Fournel M, Sapieha P, Beaulieu N, Besterman JM, MacLeod AR. 1999. Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms. J Biol Chem 274:24250-24256.
8. Hara E, Smith R, Parry D, Tahara H, Stone S, Peters G. 1996. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol 16:859-867.
9. Klangby U, Okan I, Magnusson KP, Wendland M, Lind P, Wiman KG. 1998. p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma. Blood 91:1680-1687.
10. Lania L, Majello B, De Luca P. 1997. Transcriptional regulation of the Sp family proteins. Int J Biochem Cell Biol 29:1313-1323.
11. Lee YY, Kang SH, Seo JY, Jung CW, Lee KU, Choe KJ, Kim BK, Kim NK, Koeffler HP, Bang YJ. 1997. Alterations of p16INK4A and p15INK4B genes in gastric carcinomas. Cancer 80:1889-1896.
12. Li JM, Nichols MA, Chandrasekharan S, Xiong Y, Wang XF. 1995. Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. J Biol Chem 270:26750-26753.
13. Li JM, Datto MD, Shen X, Hu PP-C, Yu Y, Wang XF. 1998. Sp1, but not Sp3, functions to mediate promoter activation by TGF-β through canonical Sp1 binding sites. Nucleic Acids Res 26:2449-2456.
14. Liew CT, Li HM, Lo KW, Leow CK, Chan JY, Hin LY, Lau WY, Lai PB, Lim BK, Huang J, Leung WT, Wu S, Lee JC. 1999. High frequency of p16INK4A gene alterations in hepatocellular carcinoma. Oncogene 18:789-795.
15. Macleod D, Charlton J, Mullins J, Bird AP. 1994. Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev 8:2282-2292.
16. Majello B, De Luca P, Hagen G, Suske G, Lania L. 1994. Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1. Nucleic Acids Res 22:4914-4921.
17. Mancini DN, Singh SM, Archer TK, Rodenhiser DI. 1999. Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors. Oncogene 18:4108-4119.
18. Morgan DO. 1995. Principles of CDK regulation. Nature 374:131-134.
19. Nakano K, Mizuno T, Sowa Y, Orita T, Yoshino T, Okuyama Y, Fujita T, Ohtani-Fujita N, Matsukawa Y, Tokino T, Yamagishi H, Oka T, Nomura H, Sakai T. 1997. Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J Biol Chem 272:22199-22206.
20. Owen GI, Richer JK, Tung L, Takimoto G, Horwitz KB. 1998. Progesterone regulates transcription of the p21(WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP/p300. J Biol Chem 273:10696-10701.
21. Pagliuca A, Cannada-Bartoli P, Lania L. 1998. A role for Sp and helix-loop-helix transcription factors in the regulation of the human Id4 gene promoter activity. J Biol Chem 273:7668-7674.
22. Prowse DM, Bolgan L, Molnar A, Dotto GP. 1997. Involvement of the Sp3 transcription factor in induction of p21Cip1/WAF1 in keratinocyte differentiation. J Biol Chem 272:1308-1314.
23. Sowa Y, Orita T, Minamikawa S, Nakano K, Mizuno T, Nomura H, Sakai T. 1997. Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. Biochem Biophys Res Commun 241:142-150.
24. Sowa Y, Orita T, Minamikawa-Hiranabe S, Mizuno T, Nomura H, Sakai T. 1999. Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. Cancer Res 59:4266-4270.
25. Swafford DS, Middleton SK, Palmisano WA, Nikula KJ, Tesfaigzi J, Baylin SB, Herman JG, Belinsky SA. 1997. Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Mol Cell Biol 17:1366-1374.
26. Tanaka T, Iwasa Y, Kondo S, Hiai H, Toyokuni S. 1999. High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats. Oncogene 18:3793-797.
27. Yan GZ, Ziff EB. 1997. Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor. J Neurosci 17:6122-6132.