메뉴 건너뛰기




Volumn 383, Issue 9, 2002, Pages 1321-1324

Dimerization inhibitors of HIV-1 protease

Author keywords

AIDS; Dimerization inhibitors; HIV 1 protease; Interface peptides; Lipopeptides; Molecular hairpins

Indexed keywords

LIPOPEPTIDE DERIVATIVE; PROTEIN DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME; PROTEINASE;

EID: 0036753937     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.150     Document Type: Article
Times cited : (58)

References (28)
  • 1
    • 0027087479 scopus 로고
    • Synthetic 'interface' peptides alter dimeric assembly of the HIV 1 and 2 proteases
    • Babé, L. M., Rose J., and Craik, C. S. (1992). Synthetic 'interface' peptides alter dimeric assembly of the HIV 1 and 2 proteases. Protein Sci. 1, 1244-1253.
    • (1992) Protein Sci , vol.1 , pp. 1244-1253
    • Babé, L.M.1    Rose, J.2    Craik, C.S.3
  • 2
    • 0033602546 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of conformationally constrained tongs, new inhibitors of HIV-1 protease dimerization
    • Bouras, A., Boggetto, N., Benatalah, Z., de Rosny, E., Sicsic, S., and Reboud-Ravaux, M. (1999). Design, synthesis, and evaluation of conformationally constrained tongs, new inhibitors of HIV-1 protease dimerization. J. Med. Chem. 42, 957-962.
    • (1999) J. Med. Chem , vol.42 , pp. 957-962
    • Bouras, A.1    Boggetto, N.2    Benatalah, Z.3    de Rosny, E.4    Sicsic, S.5    Reboud-Ravaux, M.6
  • 3
    • 0033951838 scopus 로고    scopus 로고
    • Design of dimerization inhibitors of HIV-1 aspartic proteinase: A computer-based combinational approach
    • Caflish, A., Schramm, H. J., and Karplus, M. (2000). Design of dimerization inhibitors of HIV-1 aspartic proteinase: a computer-based combinational approach. J. Comp. Aid. Mol. Des. 14, 161-179.
    • (2000) J. Comp. Aid. Mol. Des , vol.14 , pp. 161-179
    • Caflish, A.1    Schramm, H.J.2    Karplus, M.3
  • 4
    • 0032551258 scopus 로고    scopus 로고
    • Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance
    • Carr, A., Samaras, K., Chisholm, D. J., and Cooper, D. A. (1998). Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. Lancet 352, 1881-1883.
    • (1998) Lancet , vol.352 , pp. 1881-1883
    • Carr, A.1    Samaras, K.2    Chisholm, D.J.3    Cooper, D.A.4
  • 5
    • 0029011730 scopus 로고
    • Toward improved anti-HIV chemotherapy: Therapeutic strategies for intervention with HIV infections
    • de Clercq, E. (1995). Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections. J. Med. Chem. 38, 2491-2517.
    • (1995) J. Med. Chem , vol.38 , pp. 2491-2517
    • de Clercq, E.1
  • 6
    • 0027957967 scopus 로고
    • Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates
    • Darke P. L., Jordan, S. P., Hall, D. L., Zugay, J. A., Shafer, J. A., and Kuo, L. C. (1994). Dissociation and association of the HIV-1 protease dimer subunits: equilibria and rates. Biochemistry 33, 98-105.
    • (1994) Biochemistry , vol.33 , pp. 98-105
    • Darke, P.L.1    Jordan, S.P.2    Hall, D.L.3    Zugay, J.A.4    Shafer, J.A.5    Kuo, L.C.6
  • 7
    • 0011210624 scopus 로고    scopus 로고
    • Thyroxine-containing lipopeptides as interface targeting inhibitors of HIV-1 protease: A pathway to circumvent protease inhibitor resistance (P195)
    • Second General Meeting of the International Proteolysis Society associated with the International Conference on Protease Inhibitors, Freising, Germany
    • Dumond, J., Boggetto, N., Reboud-Ravaux, M., Schramm, H. J., Schramm, W., and Dölling, R. (2001). Thyroxine-containing lipopeptides as interface targeting inhibitors of HIV-1 protease: a pathway to circumvent protease inhibitor resistance (P195). Second General Meeting of the International Proteolysis Society associated with the International Conference on Protease Inhibitors, Freising, Germany.
    • (2001)
    • Dumond, J.1    Boggetto, N.2    Reboud-Ravaux, M.3    Schramm, H.J.4    Schramm, W.5    Dölling, R.6
  • 8
    • 0032475397 scopus 로고    scopus 로고
    • Inhibition of HIV-1 protease by a subunit of didemnaketal A
    • Fan, X., Flentke, G. R., and Rich, D. H. (1998). Inhibition of HIV-1 protease by a subunit of didemnaketal A. J. Am. Chem. Soc. 120, 8893-8894.
    • (1998) J. Am. Chem. Soc , vol.120 , pp. 8893-8894
    • Fan, X.1    Flentke, G.R.2    Rich, D.H.3
  • 9
    • 0027480834 scopus 로고
    • A systematic evaluation of the inhibition of HIV-1 protease by its C- and N-terminal peptides
    • Franciskovich, J., Houseman, K., Mueller, R., and Chmielewski, J. (1993). A systematic evaluation of the inhibition of HIV-1 protease by its C- and N-terminal peptides. Bioorg. Med. Chem. Lett. 3, 765-768.
    • (1993) Bioorg. Med. Chem. Lett , vol.3 , pp. 765-768
    • Franciskovich, J.1    Houseman, K.2    Mueller, R.3    Chmielewski, J.4
  • 11
    • 0026322839 scopus 로고
    • Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity
    • Kräusslich, H. (1991). Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity. Proc. Natl. Acad. Sci. 88, 1580-1584.
    • (1991) Proc. Natl. Acad. Sci , vol.88 , pp. 1580-1584
    • Kräusslich, H.1
  • 12
    • 0025989978 scopus 로고
    • Comparative analysis of the sequences and structures of HIV-1 and HIV-2 proteases
    • Gustchina, A., and Weber, I. T. (1991). Comparative analysis of the sequences and structures of HIV-1 and HIV-2 proteases. Proteins 10, 325-339.
    • (1991) Proteins , vol.10 , pp. 325-339
    • Gustchina, A.1    Weber, I.T.2
  • 13
    • 0033896165 scopus 로고    scopus 로고
    • Genetic selection for the dissociative inhibitors of designated protein-protein interactions
    • Park, S.-H., and Raines, R. T. (2000). Genetic selection for the dissociative inhibitors of designated protein-protein interactions. Nature Biotechnol. 18, 847-851.
    • (2000) Nature Biotechnol , vol.18 , pp. 847-851
    • Park, S.-H.1    Raines, R.T.2
  • 14
    • 0002768088 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication by peptidic protease inhibitors
    • N. H. Brockmeyer, R. Brodt, K. Hoffmann, G. Reimann, M. Stücker and P. Altmeyer, eds. (Berlin, Germany: Springer)
    • Petry, H., Ast, O., de Rosny, E., Lieder, K., Jentsch, K. D., Hunsmann, G., Goldmann, C., Lüke, W., Büttner, J., Reboud-Ravaux, M., Schramm, W., and Schramm, H. J. (1999). Inhibition of HIV-1 replication by peptidic protease inhibitors. In: HIV-infekt, N. H. Brockmeyer, R. Brodt, K. Hoffmann, G. Reimann, M. Stücker and P. Altmeyer, eds. (Berlin, Germany: Springer), pp. 63-67.
    • (1999) HIV-infekt , pp. 63-67
    • Petry, H.1    Ast, O.2    de Rosny, E.3    Lieder, K.4    Jentsch, K.D.5    Hunsmann, G.6    Goldmann, C.7    Lüke, W.8    Büttner, J.9    Reboud-Ravaux, M.10    Schramm, W.11    Schramm, H.J.12
  • 15
    • 0025948244 scopus 로고
    • HIV-1 reproduction is inhibited by peptides derived from the N- and C-termini of HIV-1 protease
    • Schramm, H. J., Nakashima, H., Schramm, W., Wakayama, H., and Yamamoto, N. (1991). HIV-1 reproduction is inhibited by peptides derived from the N- and C-termini of HIV-1 protease. Biochem. Biophys. Res. Commun. 179, 847-851.
    • (1991) Biochem. Biophys. Res. Commun , vol.179 , pp. 847-851
    • Schramm, H.J.1    Nakashima, H.2    Schramm, W.3    Wakayama, H.4    Yamamoto, N.5
  • 18
    • 0034604564 scopus 로고    scopus 로고
    • Small-molecules inhibitors of HIV-1 protease dimerization derived from cross-linked interfacial peptides
    • Shultz, M. D., Bowman, M. J., Ham, Y.-W., Zhao, X., Tora, G., and Chmielewski, J. (2000). Small-molecules inhibitors of HIV-1 protease dimerization derived from cross-linked interfacial peptides. Angew. Chem. Int. Ed. 39, 2710-2713.
    • (2000) Angew. Chem. Int. Ed , vol.39 , pp. 2710-2713
    • Shultz, M.D.1    Bowman, M.J.2    Ham, Y.-W.3    Zhao, X.4    Tora, G.5    Chmielewski, J.6
  • 19
    • 0033575743 scopus 로고    scopus 로고
    • Probing the role of interfacial residues in a dimerization inhibitor of HIV-1 protease
    • Shultz, M. D., and Chmielewski, J. (1999). Probing the role of interfacial residues in a dimerization inhibitor of HIV-1 protease. Bioorg. Med. Chem. Lett. 9, 2431-2436.
    • (1999) Bioorg. Med. Chem. Lett , vol.9 , pp. 2431-2436
    • Shultz, M.D.1    Chmielewski, J.2
  • 20
    • 0035903892 scopus 로고    scopus 로고
    • Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates
    • Song, M., Rajesh, S., Hayashi, Y., and Kiso, Y. (2001). Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates. Bioorg. Med. Chem. Lett. 11, 2465-2468.
    • (2001) Bioorg. Med. Chem. Lett , vol.11 , pp. 2465-2468
    • Song, M.1    Rajesh, S.2    Hayashi, Y.3    Kiso, Y.4
  • 21
    • 0032561137 scopus 로고    scopus 로고
    • The structural stability of the HIV-1 protease
    • Todd, M. J., Semo, N., and Freire, E. (1998). The structural stability of the HIV-1 protease. J. Mol. Biol. 283, 475-488.
    • (1998) J. Mol. Biol , vol.283 , pp. 475-488
    • Todd, M.J.1    Semo, N.2    Freire, E.3
  • 22
    • 0034615557 scopus 로고    scopus 로고
    • HIV protease as a target for retrovirus vector-mediated gene therapy
    • Todd, S., Anderson, C. G., Jolly, D. J., and Craik, C. S. (2000). HIV protease as a target for retrovirus vector-mediated gene therapy. Biochim. Biophys. Acta 1477, 168-188.
    • (2000) Biochim. Biophys. Acta , vol.1477 , pp. 168-188
    • Todd, S.1    Anderson, C.G.2    Jolly, D.J.3    Craik, C.S.4
  • 25
    • 0025986843 scopus 로고
    • Dissociative inhibition of dimeric enzymes. Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide
    • Zhang, Z. Y., Poorman, R. A., Maggiora, L. L., Heinrikson, R. L., and Kezdy, F. J. (1991). Dissociative inhibition of dimeric enzymes. Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide. J. Biol. Chem. 266, 15591-15594.
    • (1991) J. Biol. Chem , vol.266 , pp. 15591-15594
    • Zhang, Z.Y.1    Poorman, R.A.2    Maggiora, L.L.3    Heinrikson, R.L.4    Kezdy, F.J.5
  • 26
    • 0034605187 scopus 로고    scopus 로고
    • Targeting the dimerization interface for irreversible inhibition of HIV-1 protease
    • Zutshi, R., and Chmielewski, J. (2000). Targeting the dimerization interface for irreversible inhibition of HIV-1 protease. Bioorg. Med. Chem. Lett. 10, 1901-1903.
    • (2000) Bioorg. Med. Chem. Lett , vol.10 , pp. 1901-1903
    • Zutshi, R.1    Chmielewski, J.2
  • 27
  • 28


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.